PDE6B
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Official Full Name
phosphodiesterase 6B, cGMP-specific, rod, beta
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Overview
Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE),;resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell.;PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the;beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night;blindness. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; congenital stationary night blindness 3; autosomal dominant; CSNB3; rd1; RP40; GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E. coli
- E.coli
- HEK293
- Mammalian Cell
- Sf9 Insect Cell
- GST
- His
- His (Fc)
- Avi
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | PDE6B-1530H | Active Recombinant Human PDE6B, GST-tagged | Sf9 Insect Cell | GST | Full length |
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| Human | PDE6B-3346HCL | Recombinant Human PDE6B 293 Cell Lysate | HEK293 | N/A |
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| Human | PDE6B-3295H | Recombinant Human PDE6B protein, His-tagged | E.coli | His | 198 - 428 aa | |
| Human | PDE6B-150H | Recombinant Human PDE6B protein, GST-tagged | E. coli | GST | 1-88 aa |
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| Mouse | PDE6B-12559M | Recombinant Mouse PDE6B Protein | Mammalian Cell | His |
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| Mouse | PDE6B-6588M | Recombinant Mouse PDE6B Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Mouse | PDE6B-6588M-B | Recombinant Mouse PDE6B Protein Pre-coupled Magnetic Beads | HEK293 |
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- Involved Pathway
- Protein Function
- Interacting Protein
PDE6B involved in several pathways and played different roles in them. We selected most pathways PDE6B participated on our site, such as Purine metabolism, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Purine metabolism | PNP5A;ENTPD1;NUDT16;GMPR2;POLR3G;GUK1;POLR2L;PDE4D;XDH |
| Phototransduction | CALM;GC3;GRK1;GUCA1D;CALM3B;RLN1;RGS9A;CALML5;GC2 |
PDE6B has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6B itself. We selected most functions PDE6B had, and list some proteins which have the same functions with PDE6B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 3,5-cyclic-GMP phosphodiesterase activity | PDE6H;PDE11A;PDE9A;PDE6G;PDE5A;PDE6A;PDE6B;PDE10A;PDE6C |
| metal ion binding | TRIM55B;PDE3A;GALNT14;U2AF1L4;CYP4V8;CNOT6L;LNX2;DMPK;TDO2A |
PDE6B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PDE6B here. Most of them are supplied by our site. Hope this information will be useful for your research of PDE6B.
- Q&As
- Reviews
Q&As (5)
Ask a questionBesides retinitis pigmentosa, PDE6B mutations have been associated with certain forms of cone-rod dystrophy.
Studying PDE6B helps unravel the molecular mechanisms involved in vision, providing insights into potential therapeutic targets.
Early studies suggest that gene therapy targeting PDE6B has the potential to slow down or even restore vision in some cases of retinitis pigmentosa.
While PDE6B is primarily expressed in the retina, low levels of expression have been detected in other tissues.
PDE6B mutations can be identified through genetic testing, aiding in the diagnosis of retinal disorders.
Customer Reviews (3)
Write a reviewTo further elevate my confidence, the manufacturer's commitment to offering exemplary technical support is truly commendable.
Coupled with the manufacturer's commitment to impeccable technical support, I am equipped with the necessary tools to overcome any hurdles and achieve significant breakthroughs in my scientific pursuits.
Its purity, stability, and functional integrity are of the highest standard, instilling confidence in generating accurate and insightful results crucial for my research objectives.
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