pde6b
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  • Official Full Name
  • phosphodiesterase 6B, cGMP-specific, rod, beta
  • Background
  • Photon absorption triggers a signaling cascade in rod photoreceptors that activates cGMP phosphodiesterase (PDE),;resulting in the rapid hydrolysis of cGMP, closure of cGMP-gated cation channels, and hyperpolarization of the cell.;PDE is a peripheral membrane heterotrimeric enzyme made up of alpha, beta, and gamma subunits. This gene encodes the;beta subunit. Mutations in this gene result in retinitis pigmentosa and autosomal dominant congenital stationary night;blindness. Multiple transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PDE6B; phosphodiesterase 6B, cGMP-specific, rod, beta; PDEB; rod cGMP-specific 3,5-cyclic phosphodiesterase subunit beta; congenital stationary night blindness 3; autosomal dominant; CSNB3; rd1; RP40; GMP-PDE beta; rod cGMP-phosphodiesterase beta-subunit
Cat.#:PDE6B-480HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE6B, GST-tagged, Active
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Cat.#:PDE6B-12559MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PDE6B Protein
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Cat.#:PDE6B-1530HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PDE6B (Active), GST-tagged
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Cat.#:PDE6B-3346HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PDE6B 293 Cell Lysate
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Involved Pathway

PDE6B involved in several pathways and played different roles in them. We selected most pathways PDE6B participated on our site, such as Purine metabolism, Phototransduction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PDE6B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
AMPD2; PDE2A; PNP; POLR2E; POLR3F; POLE2; FHIT; ENTPD2; AMPD1; GUCY2E
Phototransduction
GC3; RCVRNA; CALML3; EXORH; PDE6B; RCVRN; CALM1A; CALM2A; RGS9; GUCA1C

Protein Function

PDE6B has several biochemical functions, for example, 3,5-cyclic-GMP phosphodiesterase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PDE6B itself. We selected most functions PDE6B had, and list some proteins which have the same functions with PDE6B. You can find most of the proteins on our site.
Function
Related Protein
Function 3,5-cyclic-GMP phosphodiesterase activity
Related Protein PDE6B; PDE5A; PDE10A; PDE6C; PDE6G; PDE11A; PDE9A; PDE6H; PDE6A
Function metal ion binding
Related Protein CPEB1B; SP8; ADK; STEAP1; FGG; PVALB6; RHEB; ZFP106; TGM5; ME2