pik3cb
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  • Official Full Name
  • phosphoinositide-3-kinase, catalytic, beta polypeptide
  • Background
  • This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important;in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic;subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the;activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative;splicing results in multiple transcript variants.
  • Synonyms
  • PIK3CB; phosphoinositide-3-kinase, catalytic, beta polypeptide; PIK3C1; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform; PI3K-beta; PtdIns-3-kinase p110; PI3-kinase subunit beta; PI3-kinase p110 subunit beta; ptdIns-3-kinase
Cat.#:PIK3CB/PIK3R1-391HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, His-tagged, Active
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Cat.#:PIK3CB/PIK3R1-632HTag:Flag
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1, FLAG-tagged
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Cat.#:PIK3CB&PIK3R1-155HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R1 protein, His-tagged, Active
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Cat.#:PIK3CB&PIK3R2-156HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB/PIK3R2 protein, His-tagged, Active
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Cat.#:PIK3CB-1724HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PIK3CB protein, His-tagged
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Cat.#:PIK3CB-214HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PIK3CB
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Cat.#:PIK3CB-31095THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3CB-31766THTag:His
Source (Host):Species:Human
Product nameRecombinant Human Human PIK3CB, His-tagged
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Cat.#:PIK3CB-620HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PIK3CB
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Cat.#:PIK3CB-12802MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PIK3CB Protein
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Cat.#:PIK3CB-4461RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PIK3CB Protein
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Cat.#:PIK3CB-2965CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PIK3CB
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Cat.#:PIK3CB-3188HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PIK3CB 293 Cell Lysate
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Involved Pathway

PIK3CB involved in several pathways and played different roles in them. We selected most pathways PIK3CB participated on our site, such as Inositol phosphate metabolism, ErbB signaling pathway, Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Inositol phosphate metabolism
PIK3C2G; MTMR8; PLCD4; SYNJ1; MTMR1A; PIP5K1C; IPMKB; PLCD1A; PTENB; ITPKC
ErbB signaling pathway
PRKCB; PTK2; HBEGFA; CAMK2B; CDKN1BB; SHC2; HRAS; PLCG2; PAK4; PAK6B
Ras signaling pathway
GNGT2; ABL2; PRKACB; BCL2L1; PRKCG; PTPN11; STK4; MLLT4; PLA2G1B; RAP1A
Rap signaling pathway
FLT4; NRAS; VEGFA; ITGB1; VEGFC; PRKD3; FGF20; IGF1; FGF3; PLCB3
cGMP-PKG signaling pathway
PLCB1; PPP1R12A; VASP; VDAC2; NOS3; PLCB4; CREB3L2; IRS2; CREB5; ROCK2
cAMP signaling pathway
HCAR3; GRIN2B; CALM1; CAMK2A; FOS; GRIA2; FXYD2; PPP1CC; HTR1A; HTR1F
Chemokine signaling pathway
PPBP; CXCL1; GNGT1; CCL24; CCL20; RAP1B; RELA; CCL3; PRKACB; PIK3R1
HIF- signaling pathway
HMOX1; CUL2; HK2; TF; MAPK3; GM5506; INS1; ARNT; HK1; ALDOA
FoxO signaling pathway
SGK2A; KLF2B; TNFSF10; PLK2; TGFB2; FBXO32; SOS1; INSB; INSR; ATG12
Phosphatidylinositol signaling system
PIP5K1BB; ITPKA; MTMR7; IMPA1; ITPK1A; INPP5D; CDS2; PIK3C2B; PRKCG; PIP4K2C
Sphingolipid signaling pathway
NFKB1; PLCB2; PPP2CA; OPRD1; BDKRB2; CERS4; S1PR4; PPP2CB; SGPP2; PPP2R1A
Phospholipase D signaling pathway
PLCG1; AGPAT3; PRKCA; PIK3R5; GRM2; NRAS; SPHK1; LPAR3; LPAR4; DGKD
mTOR signaling pathway
PTENB; TSC1A; INSB; RRAGCA; RPS6KA3; PDPK1B; TSC1; CAB39; DDIT4; RPS6
PIK-Akt signaling pathway
ITGB3; GNG13; GNG11; DDIT4; BCL2; CCND3; IFNA4; CASP9; GH2; TNR
AMPK signaling pathway
AKT1; EEF2; CRTC2; PPP2CA; HNF4A; PIK3CA; CREB3L1; PPP2R5E; PRKAB2; PFKL
Apoptosis
DBNLA; CAPN1B; IL1R1; BCL2L11; BCL2; RELA; CAPN2B; HIST1H1C; BNIP3L; TNFRSF1A
Adrenergic signaling in cardiomyocytes
RAPGEF3; PIK3CG; KCNQ1; AKT2L; ADCY1A; ATP1A4; PIK3CB; PIK3CA; PLCB2; CALM
VEGF signaling pathway
PLA2G4AA; BADB; VEGFA; PLA2G4F; PPP3R1; MAP2K2B; PPP3CCA; PTK2AA; PPP3CCB; RAF1B
Osteoclast differentiation
PIK3R2; TGFBR2; FCGR2B; BTK; CSF1; IFNGR2; SPI1; MAP2K7; ACP5; PIK3CD
Focal adhesion
VCL; VWF; HGF; PTK2AA; PRKCB; ERBB2; PPP1CA; VTNB; THBS2; COL5A2A
Signaling pathways regulating pluripotency of stem cells
HRAS; ESRRB; AXIN2; PCGF6; MEIS1; PIK3CB; INHBB; ACVR1B; BMI1; SOX2
Platelet activation
PPP1CA; GP9; NOS3; PIK3CB; AKT2; TBXA2R; SRC; RAP1B; PLA2G4C; BTK
Toll-like receptor signaling pathway
MAPK1; CCL5; TLR5; MAP2K2B; PIK3CG; AKT3A; SPP1; TMED7-TICAM2; IRF5; IL-8
Jak-STAT signaling pathway
PIK3CA; PIK3R1; IL7; OSMR; IFNA2; OSM; IL2RGB; GM13305; Il4ra; AKT3A
Natural killer cell mediated cytotoxicity
KRAS; ULBP2; MAPK3; BID; HLA-B; KIR3DL1; HCST; PPP3CC; MAP2K1; SH2D1A
T cell receptor signaling pathway
VAV1; PPP3CA; MAPK3; MAPK9; EVLB; NFATC3; CD247; MAPK13; LCK; PPP3R1
B cell receptor signaling pathway
ITK; DOK3; NFATC2; CMTM3; ACTR3; CDK7; ARPC2; VAV1; BANK1; MAPK4
Fc epsilon RI signaling pathway
GRB2; MAPK13; RAC3; FYN; PIK3CD; VAV2; IL4; IL13; PLA2G4B; MAPK3
Fc gamma R-mediated phagocytosis
LIMK1; VAV1; WAS; PLA2G4F; PLCG2; FCGR3A; LAT; SPHK2; PRKCA; PRKCD
TNF signaling pathway
RPS6KA5; MAPK8; IKBKB; ITCH; MAP3K7; IL1B; MAPK12; CASP7; BCL3; MAPK10
Leukocyte transendothelial migration
RAP1B; ITGAM; CLDN20; CLDN22; ARHGAP35; MAPK12; ACTG1; VASP; JAM3; ACTN3
Neurotrophin signaling pathway
PIK3R1; CAMK2B; MAPK10; IRS1; MAPK11; RAP1A; NGF; AKT1; PSEN2; NTF4
Cholinergic synapse
PIK3CB; CREB5; GNB4; CREB3; CAMK2B; KCNJ6; GNG4; CAMK2G; CHRM2; PLCB2
Inflammatory mediator regulation of TRP channels
F2RL1; PLCB3; NGF; CAMK2G; PRKACG; CYP2J6; TRPV4; ACCN4; CALM1; PRKCH
Regulation of actin cytoskeleton
ITGA7; EZRB; EGFRA; Itga10&Itgb1; RAC2; ARHGEF1; PDGFA; FGF10; MYLK3; PIP5KL1
Insulin signaling pathway
RPS6KB1B; FASN; PDPK1; NRAS; RAPGEF1B; GRB2; MAP2K2; RPS6; INS2; PHKG1B
Progesterone-mediated oocyte maturation
RPS6KA2; PRKACAA; CDC27; INS1; RAF1; PRKACA; MAPK10; RPS6KAL; PRKACAB; BRAF
Estrogen signaling pathway
MAPK1; PIK3CG; PLCB1; SOS1; GRM1; CALM4; HSP90AB1; FKBP5; ATF4; SHC1
Prolactin signaling pathway
MAP2K1; PRP2; PIK3R3; NRAS; MAPK9; SHC4; NFKB1; PIK3CG; NEK3; MAPK8
Thyroid hormone signaling pathway
RXRA; STAT1; PFKP; NCOA3; RCAN2; ATP1A4; PLCD1; MED1; SLC2A1; NOTCH3
Oxytocin signaling pathway
FOS; PRKCG; PRKCA; PLA2G4D; GNAO1; PLA2G4F; PIK3R1; PLCB3; RHOA; CAMKK1
Regulation of lipolysis in adipocytes
GNAS; PIK3R2; PRKACB; LIPE; IRS4; TSHB; PIK3R1; IRS2; PIK3CB; AKT1
Type II diabetes mellitus
INS-IGF2; SOCS4; PKM; INS2; PRKCE; PDX1; PIK3R5; MAPK9; IRS4; IKBKB
Insulin resistance
PRKCQ; PPP1CC; PRKAG3B; PRKCB; PDPK1; MAPK8; G6PC; AKT2; IRS2; RPS6KB1
Non-alcoholic fatty liver disease (NAFLD)
NDUFB1; NR1H3; NDUFA10; Fasl; NDUFB6; COX5A; TNF; EIF2AK3; NDUFA12; NDUFB4
Aldosterone-regulated sodium reabsorption
INSR; FXYD4; ATP1B4; SLC9A3R2; PRKCG; PRKCB; PIK3CA; ATP1B3; ALPHA-ENAC; PIK3R2
Carbohydrate digestion and absorption
GNAT3; AMY2A; AMY1B; HKDC1; PIK3R5; AMY2A2; SI; PLCB2; FXYD2; SLC37A4
Bacterial invasion of epithelial cells
CBLB; ITGB1; DNM1; CD2AP; CAV3; PIK3R2; ARPC2; PIK3R1; SHC3; CLTC
Chagas disease (American trypanosomiasis)
MAPK11; TNF; IRAK1; CCL3L1; GNAI1; C1QB; CCL5; MAPK10; GNA11; TLR2
Toxoplasmosis
TGFB2; NFKB1; HLA-DRB5; GNAI1; PPIF; Toxoplasma Gondii Major Surface Antigen P30; BAD; HLA-DOB; CYCS; LAMA4
Amoebiasis
LAMB2; RAB7B; PRKCB; SERPINB1A; LAMB1; LAMC2; PIK3R2; PLCB3; SERPINB13; GNA11
Hepatitis C
MAPK13; IFNA21; SOS1; TRAF3; LDLR; IRF1; OAS1; CLDN10; MAPK10; PPP2R1B
Hepatitis B
PTK2B; SMAD3; PRKCB; Fasl; TIRAP; IFNA12; MAPK1; CCNE2; IFIH1; CASP10
Measles
CD209B; OAS3; IFIH1; TRP53; SH2D1A; STAT2; IFNA17; PIK3CG; IRF7; CBLB
Influenza A
MAPK1; MAPK8; VDAC1; CXCL10; LOC100686744; SOCS3; TNF; NXT2; HLA-DOB; XPO1
HTLV-I infection
RANBP1; PIK3CG; PIK3R3; FZD1; POLB; DVL3; WNT2B; CRTC2; ELK1; RB1
Epstein-Barr virus infection
NCOR2; PLCG2; POLR1C; POLR2D; PRKACG; HLA-G; POLR1D; IRF3; POLR2H; TRAF5
Pathways in cancer
GLI3; GLI2; AKT2; PIK3CA; LAMB3; TP53; SPI1; NOS2; MMP9; MET
Viral carcinogenesis
CREB3L3; PIK3CA; HIST2H4A; GTF2H2C; GTF2E2; SCIN; ATF4; HIST1H2BK; GTF2E1; H2BFWT
Proteoglycans in cancer
CAMK2D; WNT6; MDM2; HOXD10; SRC; FGF2; FZD7; WNT7A; PIK3R3; WNT5A
Colorectal cancer
Casp3; PIK3CB; GSK3B; MLH1; BCL2; PIK3R5; RHOA; LEF1; TCF7L2; RAC2
Renal cell carcinoma
MAPK1; NRAS; PIK3CD; CUL2; TCEB2; MAPK3; MAP2K2; EGLN2; RAP1B; PTPN11
Pancreatic cancer
BAD; KRAS; SMAD3; TGFB2; TGFA; STAT3; TGFBR2; AKT1; BRCA2; ARHGEF6
Endometrial cancer
PIK3CG; PTEN; NRAS; AXIN1; TCF7; BRAF; KRAS; BAD; GSK3B; SOS1
Glioma
BRAF; PIK3CB; IGF1R; MDM2; Pdgfa&Pdgfb; PDGFA; PRKCA; CALM1; HRAS; AKT1
Prostate cancer
IGF1; RELA; PDGFRA; GSTP1; Pdgfa&Pdgfb; PIK3CG; PDGFA; SRD5A2; MAPK3; NFKBIA
Melanoma
TRP53; FGF22; PDGFC; BAD; CCND1; IGF1R; PIK3CA; PIK3R3; PIK3CD; PDGFB
Chronic myeloid leukemia
PIK3R2; SHC4; RUNX1; CBLB; TGFBR1; STAT5B; AKT2; PTPN11; BRAF; TGFBR2
Acute myeloid leukemia
PIK3CA; IKBKB; RPS6KB2; KIT; PIK3CG; STAT5A; CCNA1; CCND1; AKT3; FLT3
Small cell lung cancer
ITGAV; PTEN; LAMA4; RXRB; TRAF2; APAF1; PIAS2; LAMC2; FHIT; TRAF6
Non-small cell lung cancer
TP53; PRKCA; RASSF1; NRAS; PIK3CB; ALK; AKT1; PIK3R1; PIK3R5; FOXO3
Central carbon metabolism in cancer
SLC1A5; IDH1; PDGFRB; FLT3; PKM; NRAS; KIT; HKDC1; G6PDX; PDHA2
Choline metabolism in cancer
DGKD; NRAS; PIK3R5; TSC1; AKT2; PLCG1; SLC5A7; SLC22A3; MAP2K1; PDGFRB

Protein Function

PIK3CB has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity, 1-phosphatidylinositol-4-phosphate 3-kinase activity, ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CB itself. We selected most functions PIK3CB had, and list some proteins which have the same functions with PIK3CB. You can find most of the proteins on our site.
Function
Related Protein
Function 1-phosphatidylinositol-3-kinase activity
Related Protein ATM; PIK3R3; PIK3C2A; PIK3CG; PIK3CA; PIK3C3; PIK3CB; PIK3CD; PIK3C2G; PIK3C2B
Function 1-phosphatidylinositol-4-phosphate 3-kinase activity
Related Protein PIK3CD; PIK3C2G; PIK3CA; PIK3CB; PIK3C2A; PIK3C2B; PIK3CG
Function ATP binding
Related Protein OXSR1A; MATK; TAP2; TTN; GK2; MAP4K4; PFKL; SYN1; ACSBG2; NME1
Function insulin receptor substrate binding
Related Protein INSRA; INSRB; IGF1RB; GRB2; PIK3CA; PRKCD; JAK2; PIK3R1; INSRR; IGF1RA
Function phosphatidylinositol 3-kinase activity
Related Protein PIK3CA; PIK3CG; PIK3CD; PIK3C2A; PIK3CB
Function phosphatidylinositol-4,5-bisphosphate 3-kinase activity
Related Protein PIK3CA; PIK3CD; PIK3CG; PIK3CB
Function protein binding
Related Protein FOS; C9orf9; TAF6; PTPRE; CAMK1; ATP6V1E1; MTCH1; SP100; IMPA1; POLR2C

Interacting Protein

PIK3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CB.
PIK3R2; PIK3R1; PIK3R3; YWHAQ; HCK; TFCP2; ALAS1; HPS6; DVL3; NS; NS; ERBB3