pla2g2a
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  • Official Full Name
  • phospholipase A2, group IIA (platelets, synovial fluid)
  • Background
  • Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (Type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family.2 This enzyme, rather than the sPLA2 (Type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells. Consistent with this role, sPLA2 (Type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells. sPLA2 (Type V) has been cloned from a variety of species including human, mouse, and rat. The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells
  • Synonyms
  • PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated; GIIC sPLA2; enhancing factor; modifier of Min1; group IIA phospholipase A2; secretory group II phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secreted type II phospholipase A2; EF; Mom1; Pla2; sPLA2; sPla2-IIA
Cat.#:PLA2G2A-1582RTag:His
Source (Host):YeastSpecies:Rat
Product nameRecombinant Rat PLA2G2A Protein (22-146 aa), His-tagged
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Cat.#:PLA2G2A-522MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse PLA2G2A Protein, His-tagged
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Cat.#:PLA2G2A-1885HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G2A Protein, MYC/DDK-tagged
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Cat.#:PLA2G2A-1031HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G2A, His-tagged
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Cat.#:PLA2G2A-01HTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G2A
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Cat.#:PLA2G2A-1036HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human, PLA2G2A His-tagged
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Cat.#:PLA2G2A-669HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PLA2G2A protein, His-tagged
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Cat.#:PLA2G2A-900HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G2A, His tagged
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Cat.#:PLA2G2A-12888MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G2A Protein
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Cat.#:Pla2g2a-670MTag:His
Source (Host):Baculovirus Sf 21 Insect cellsSpecies:Mouse
Product nameRecombinant Mouse Pla2g2a, His-tagged
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Cat.#:PLA2G2A-4488RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLA2G2A Protein
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Cat.#:Pla2g2a-8259RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pla2g2a protein, His & GST-tagged
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Cat.#:PLA2G2A-5247CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G2A
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Cat.#:PLA2G2A-2184HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human PLA2G2A cell lysate
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Involved Pathway

PLA2G2A involved in several pathways and played different roles in them. We selected most pathways PLA2G2A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
ADPRM; GPD1C; PCYT1BB; GPD1; DGKAA; LPGAT1; PCYT1AB; PLB1; DGKG; PHOSPHO1
Ether lipid metabolism
PLA2G2D; LPCAT2; PAFAH1B1; GAL3ST1A; PPAP2C; PLA2G12A; UGT8; PLA2G4C; PLA2G4F; CEPT1B
Arachidonic acid metabolism
PLB1; PLA2G3; CYP2C70; PTGES3A; CYP2C19; AKR1C21; CYP4T8; PTGR1; GPX7; MAPKAPK2B
Linoleic acid metabolism
PLA2G4AA; PLA2G3; CYP2C55; PLA2G5; PLA2G2D; PLA2G2A; PLA2G12A; CYP2C54; PLA2G6; PLA2G4A
alpha-Linolenic acid metabolism
PLA2G10; PLA2G4F; PLA2G1B; PLA2G5; ACOX3; PLA2G2F; PLA2G4D; ACAA1A; PLA2G12A; PLA2G2E
Metabolic pathways
PYCR1A; TPH1B; COX5AA; MMAB; COX6C; CYP2P6; CYP2R1; DCTPP1; TPI1A; HSD3B5
Ras signaling pathway
RASA3; FGF5; RALBP1; RRAS2; RASA1; GNB3; MAP2K1; MAPK3; ANGPT2; HGF
Vascular smooth muscle contraction
CALML5; PPP1R12B; MYL6; GNA11A; PLA2G6; MAPK3; ADCY1B; MYH11; PRKCG; GNA12
Pancreatic secretion
BST1; AMY2A4; ATP1A1; ATP1B2; FXYD2; PRSS2; TRPC1; CELA3B; PLA2G1B; CA2
Fat digestion and absorption
PLA2G1B; PLA2G2D; AGPAT2; ABCG8; AGPAT1; APOA4; PLA2G12A; PNLIPRP2; PLA2G2F; PPAP2B

Protein Function

PLA2G2A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2A itself. We selected most functions PLA2G2A had, and list some proteins which have the same functions with PLA2G2A. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MYO5A; CIB2; PVALB1; MAN1B1; EFCAB6; LRP2; NCAN; PCDH18A; SLC24A4A; RHOT1A
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G4F; PLA2G4A; PLA2G1B; PLA2G3; PLA2G2A; PLA2G12A; PLA2G4B; PLA2G5
Function phospholipase A2 activity
Related Protein PLA2G12B; PLA2G16; PLA2G1B; PRDX6; PLA2G2E; PLA2G4A; PLA2G6; PLA2G2A; PLB1; LCAT
Function phospholipid binding
Related Protein NR5A1; SPTBN2; ESYT1; NOXO1; F3; FABP1; SPTBN1; PACSIN1A; PACSIN1; SHC1

Interacting Protein

PLA2G2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2A.
ALOX12; CRMP1; CRELD2; CEP70