|Official Full Name||phospholipase A2, group IIA (platelets, synovial fluid)|
|Background||Phospholipase A2 (PLA2) catalyzes the hydrolysis of fatty acids at the sn-2 position of glycerophospholipids. PLA2 (Type V) is a secretory PLA2 (sPLA2) of approximately 14 kDa and is one of the isoforms in the growing list of the PLA2 enzyme family.2 This enzyme, rather than the sPLA2 (Type II), is responsible for arachidonic acid mobilization leading to prostaglandin production in macrophages and mast cells. Consistent with this role, sPLA2 (Type V) is associated with the golgi apparatus, nuclear envelope, and plasma membrane in murine bone marrow-derived mast cells. sPLA2 (Type V) has been cloned from a variety of species including human, mouse, and rat. The enzyme is expressed in heart, lung, placenta, and spleen, as well as P388D1 macrophages and mast cells|
|Synonyms||PLA2G2A; phospholipase A2, group IIA (platelets, synovial fluid); phospholipase A2, membrane associated; GIIC sPLA2; enhancing factor; modifier of Min1; group IIA phospholipase A2; secretory group II phospholipase A2; phosphatidylcholine 2-acylhydrolase 2A; non-pancreatic secreted type II phospholipase A2; EF; Mom1; Pla2; sPLA2; sPla2-IIA|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PLA2G2A involved in several pathways and played different roles in them. We selected most pathways PLA2G2A participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G2A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Glycerophospholipid metabolism||PLA2G4A; PLA2G2D; PLD3; MBOAT2; PPAP2CB; ETNK1; PPAP2C; ADPRM; PHYKPL; CHPT1|
|Ether lipid metabolism||PLD3; PLA2G3; PPAP2A; PLA2G4A; PLD1; PLA2G4F; PAFAH2; PLA2G2F; PLD2; GAL3ST1A|
|Arachidonic acid metabolism||PLA2G12A; ALOX5B.3; PLA2G4F; CYP4B1; PTGR1; PLA2G4B; CYP2P10; GPX5; PLA2G2E; CYP2AD2|
|Linoleic acid metabolism||PLA2G4D; CYP2P7; CYP2J2; CYP2C37; PLA2G12A; CYP2C55; PLA2G2A; CYP2C70; DHRS13L1; PLA2G4F|
|alpha-Linolenic acid metabolism||PLA2G4D; PLA2G4C; PLA2G2E; FADS2; PLA2G4F; ACOX1; PLA2G12A; ACAA1; PLA2G1B; PLA2G2A|
|Metabolic pathways||MAT2A; GLUD1A; NMNAT2; UGT1A6A; FBP1B; TDO2A; NME4; CEL.1; PNPO; BCMO1|
|Ras signaling pathway||PLA2G5; PLCG2; MAP2K2; PIK3R5; PLA2G4D; RAP1B; NFKB1; RASA1; FGF12; PDGFRA|
|Vascular smooth muscle contraction||CALM3A; PRKCBB; CALCRLA; MYH11; ADORA2AB; RHOA; AGTR1A; CALM2B; ROCK2; ADCY1B|
|Pancreatic secretion||PLCB2; RAB27B; CPB1; GNAQ; KCNMA1; CPA2; RAP1B; ATP2B1; PRSS1; FXYD2|
|Fat digestion and absorption||PLA2G5; MTTP; PPAP2C; PLA2G2F; PNLIPRP2; SLC27A4; MOGAT2; ABCA1; LIPF; Cel|
PLA2G2A has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G2A itself. We selected most functions PLA2G2A had, and list some proteins which have the same functions with PLA2G2A. You can find most of the proteins on our site.
|calcium ion binding||ANXA9; JAG2B; NOL3; PLS1; SYT4; FSTL5; ALOX15B; CDHR1; CDH12A; GSNB|
|calcium-dependent phospholipase A2 activity||PLA2G1B; PLA2G4B; PLA2G5; PLA2G3; PLA2G4F; PLA2G4A; PLA2G2A; PLA2G12A|
|phospholipase A2 activity||PLA2G12B; PLA2G2A; PLA2G16; PLA2G2E; LCAT; RARRES3; PLA2G10; PLA2G4A; PLB1; PLA2G4AA|
|phospholipid binding||MTAP1B; PACSIN1A; MYOF; NSFL1C; APOA5; ESYT1; PLA2G15; GRK5; PSD2; APOH|
PLA2G2A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G2A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G2A.
ALOX12; CRMP1; CRELD2; CEP70