pla2g5
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  • Official Full Name
  • phospholipase A2, group V
  • Background
  • This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.
  • Synonyms
  • PLA2G5; phospholipase A2, group V; calcium-dependent phospholipase A2; Ca2+ dependent phospholipase A2; Calcium dependent phospholipase A2; DKFZp686C2294; Group V phospholipase A2; GV PLA2; gVPLA2; hVPLA(2); MGC46205; OTTHUMP00000044655; PA2G5_HUMAN; Phosphatidylcholine 2 acylhydrolase; Phosphatidylcholine 2-acylhydrolase 5; Phospholipase A2 group V; PLA2 10; PLA2 G5; PLA2-10; sPLA2 Type V; OTTHUMP00000002785; Ca2+-dependent phospholipase A2; GV-PLA2
Cat.#:Pla2g5-1412MTag:His/SUMO
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pla2g5 Protein, His-SUMO-tagged
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Cat.#:PLA2G5-71HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Phospholipase A2, Group V, His-tagged
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Cat.#:PLA2G5-31349THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PLA2G5, His-tagged
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Cat.#:PLA2G5-12900MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PLA2G5 Protein
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Cat.#:PLA2G5-4490RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PLA2G5 Protein
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Cat.#:PLA2G5-3455RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PLA2G5 Protein, His-tagged
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Cat.#:PLA2G5-5325CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PLA2G5
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Involved Pathway

PLA2G5 involved in several pathways and played different roles in them. We selected most pathways PLA2G5 participated on our site, such as Glycerophospholipid metabolism, Ether lipid metabolism, Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G5 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Glycerophospholipid metabolism
PPAP2C; PLA2G2A; PTDSS1A; PCYT1A; PMT; AGPAT9L; AGPAT9; MBOAT7; PTDSS2; PISD
Ether lipid metabolism
PPAP2A; PLA2G3; PLA2G12A; CHPT1; PLD4; PAFAH1B2; LPCAT2; ENPP6; PLA2G12B; PPAP2CB
Arachidonic acid metabolism
HPGDS; CYP4A11; PTGDSB; CYP4F22; PLA2G5; ALOX12E; ALOX12; CYP4F2; CYP2C19; GGT1A
Linoleic acid metabolism
CYP2P8; PLA2G2F; CYP2J5; PLA2G5; PLA2G2D; PLA2G12A; CYP3A41A; CYP2P9; CYP2J2; CYP2C19
alpha-Linolenic acid metabolism
PLA2G2F; PLA2G1B; ACAA1A; PLA2G2D; PLA2G4F; PLA2G6; PLA2G3; PLA2G12B; PLA2G5; PLA2G10
Metabolic pathways
GALNT3; GLCE; LIPCA; MTHFD1L; PIGM; PIP5K1AA; ATP6V0A1; AMACR; NAMPTB; NMRK1
Ras signaling pathway
FGFR1; RRAS2; ANGPT1; AKT2; STK4; KITLG; GRIN2B; FGF12; RALGDS; FGF3
Vascular smooth muscle contraction
ARHGEF12; PRKACAA; CYP4A10; MYL12.1; PRKCE; ITPR1; ARHGEF11; EDNRAA; GNAS; PPP1R12C
Pancreatic secretion
PLCB3; PLCB1; PLCB4; PRKCA; PNLIPRP1; ITPR3; CELA3B; GNAS; CA2; SLC4A4
Fat digestion and absorption
PLA2G2E; ABCA1; GOT2; ACAT2; MOGAT2; FABP2; CD36; PPAP2B; PLA2G3; LIPF

Protein Function

PLA2G5 has several biochemical functions, for example, calcium ion binding, calcium-dependent phospholipase A2 activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G5 itself. We selected most functions PLA2G5 had, and list some proteins which have the same functions with PLA2G5. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein SLC25A12; CAPS; MMP14B; SLIT1A; DGKAA; CDH20; PCDHB5; EGF; FBN2B; MMP30
Function calcium-dependent phospholipase A2 activity
Related Protein PLA2G4A; PLA2G1B; PLA2G4F; PLA2G4B; PLA2G5; PLA2G2A; PLA2G12A; PLA2G3
Function heparin binding
Related Protein CCL7; CTGF; APLP2; PLA2G2D; APOB; SLIT3; SFRP1; PGF; PLA2G5; REG4

PLA2G5 Related Articles

Xue, ML; Shen, K; et al. Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A(2). ARTHRITIS RESEARCH & THERAPY 16:-(2014).
Meliton, AY; Munoz, NM; et al. Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L689-L700(2013).