PLA2G5

  • Official Full Name

    phospholipase A2, group V

  • Overview

    This gene is a member of the secretory phospholipase A2 family. It is located in a tightly-linked cluster of secretory phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined.

  • Synonyms

    PLA2G5;phospholipase A2, group V;calcium-dependent phospholipase A2;Ca2+ dependent phospholipase A2;Calcium dependent phospholipase A2;DKFZp686C2294;Group V phospholipase A2;GV PLA2;gVPLA2;hVPLA(2);MGC46205;OTTHUMP00000044655;PA2G5_HUMAN;Phosphatidylcholine 2 acylhydrolase;Phosphatidylcholine 2-acylhydrolase 5;Phospholipase A2 group V;PLA2 10;PLA2 G5;PLA2-10;sPLA2 Type V;OTTHUMP00000002785;Ca2+-dependent phospholipase A2;GV-PLA2

Recombinant Proteins

  • Mouse
  • Rhesus macaque
  • Rat
  • Chicken
  • Human
  • Mammalian Cells
  • E.coli
  • Yeast
  • HEK293
  • His
  • SUMO
  • Avi
  • Fc

    Involved Pathway

    PLA2G5 involved in several pathways and played different roles in them. We selected most pathways PLA2G5 participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    alpha-Linolenic acid metabolism FADS2,PLA2G3,PLA2G2A,PLA2G6,ACOX1,PLA2G4AA,ACAA1A,ACAA1,PLA2G2F,PLA2G2D
    Ras signaling pathway FGF17,ETS1,NGF,MAP2K1,PRKCB,ELK1,PLA2G12B,INS2,KITLG,TBK1
    Linoleic acid metabolism CYP2C50,PLA2G4C,PLA2G2D,PLA2G2E,PLA2G4AA,PLA2G3,CYP2P9,CYP2C19,CYP3A65,CYP2C39
    Glycerophospholipid metabolism PLD3,PLD1A,DGKD,PNPLA6,MBOAT2,CDS2,AGPAT9L,CHAT,LYPLA2,GPCPD1
    Pancreatic secretion ATP1B3,PNLIPRP1,PRKCA,CELA2B,SLC9A1,PLA2G2E,ATP1A2,CPB1,PLA2G2F,AMY2A
    Metabolic pathways PNMT,IPPK,GCH2,HSD17B2,ASNS,TDO2B,IMPDH1A,RDH11,PGK1,GMPS
    Vascular smooth muscle contraction ACTG2,PRKACBB,CACNA1DA,PRKCB,CALM,ROCK1,PRKCE,MAP2K2B,PLA2G2D,Adcy4
    Arachidonic acid metabolism PLA2G10,PTGDSB,PLA2G4D,PTGES3A,ALOX5A,PTGESL,EPHX2,ALOX8,PLA2G4AA,ALOX12E
    Fat digestion and absorption PLA2G12B,PLA2G2F,PNLIPRP2,PLA2G10,DGAT1,CLPS,DGAT2,PLA2G3,LIPF,FABP2

    Protein Function

    PLA2G5 has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase A2 activity,heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G5 itself. We selected most functions PLA2G5 had, and list some proteins which have the same functions with PLA2G5. You can find most of the proteins on our site.

    Function Related Protein
    calcium-dependent phospholipase A2 activity PLA2G12A,PLA2G4A,PLA2G4B,PLA2G3,PLA2G2A,PLA2G1B,PLA2G4F
    calcium ion binding PCDH2G6,S100A11,RHOT1A,EFCAB10,DCHS1,PNLIPRP2,PVALB9,ACTN2,PCDH7,PCDHGA12
    heparin binding ADAMTS3,FGF7,CLEC3B,CXCL11,BMP7,HDGF,NAV2,ZNF146,FGF2,VEGFAB

    Interacting Protein

    PLA2G5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G5 here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G5.

    Resources

    References

    • Xue, ML; Shen, K; et al. Endothelial protein C receptor-associated invasiveness of rheumatoid synovial fibroblasts is likely driven by group V secretory phospholipase A(2). ARTHRITIS RESEARCH & THERAPY 16:-(2014).
    • Meliton, AY; Munoz, NM; et al. Mechanical induction of group V phospholipase A(2) causes lung inflammation and acute lung injury. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 304:L689-L700(2013).

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