pmaip1
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  • Official Full Name
  • phorbol-12-myristate-13-acetate-induced protein 1
  • Background
  • Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1 (By similarity). Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
  • Synonyms
  • PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1; APR; NOXA; protein Noxa; PMA-induced protein 1; immediate-early-response protein APR; adult T cell leukemia-derived PMA-responsive;
Cat.#:PMAIP1-1803HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PMAIP1, His-tagged
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Cat.#:PMAIP1-13007MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PMAIP1 Protein
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Cat.#:PMAIP1-4539RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PMAIP1 Protein
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Cat.#:PMAIP1-3482RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PMAIP1 Protein, His-tagged
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Cat.#:PMAIP1-4415ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PMAIP1
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Cat.#:PMAIP1-3090HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PMAIP1 293 Cell Lysate
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Involved Pathway

PMAIP1 involved in several pathways and played different roles in them. We selected most pathways PMAIP1 participated on our site, such as p signaling pathway, Viral carcinogenesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PMAIP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
p signaling pathway
BAX; GADD45BA; TRP53; GADD45AB; GADD45BB; CASP8; RPRM; RCHY1; EI24; SESN1
Viral carcinogenesis
HIST3H2BB-PS; EIF2AK2; PIK3CG; MDM2; H2BFWT; HPN; KRAS; HIST1H4J; CCNA1; HDAC3

Protein Function

PMAIP1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PMAIP1 itself. We selected most functions PMAIP1 had, and list some proteins which have the same functions with PMAIP1. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein HTR6; MARCH10; NBL1; PRR3; FAM168A; TCTE3; RHOT1; CASP7; ERCC5; FAM115A

Interacting Protein

PMAIP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMAIP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PMAIP1.
MCL1; BCL2L1; BCL2L2; BCL2; BCL2; Mcl1; Bcl2a1; BCL2L11; f1_vaccp