Recombinant Human PMAIP1 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: PMAIP1-3049H
• Product Overview: PMAIP1 MS Standard C13 and N15-labeled recombinant protein (NP_066950) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Promotes activation of caspases and apoptosis. Promotes mitochondrial membrane changes and efflux of apoptogenic proteins from the mitochondria. Contributes to p53/TP53-dependent apoptosis after radiation exposure. Promotes proteasomal degradation of MCL1. Competes with BAK1 for binding to MCL1 and can displace BAK1 from its binding site on MCL1. Competes with BIM/BCL2L11 for binding to MCL1 and can displace BIM/BCL2L11 from its binding site on MCL1.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 5.8 kDa
• AA Sequence: MPGKKARKNAQPSPARAPAELEVEC ATQLRRFGDKLNFRQKLLNLISKLF CSGTTRTRPLEQKLISEEDLAANDI LDYKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 [ Homo sapiens (human) ]
• Official Symbol: PMAIP1
• Synonyms: PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1; APR; NOXA; protein Noxa; PMA-induced protein 1; immediate-early-response protein APR; adult T cell leukemia-derived PMA-responsive
• Gene ID: 5366
• mRNA Refseq: NM_021127
• Protein Refseq: NP_066950
• MIM: 604959
• UniProt ID: Q13794