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PMEL

  • Official Full Name

    premelanosome protein

  • Overview

    This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants.
  • Synonyms

    PMEL; premelanosome protein; P1; SI; SIL; ME20; P100; SILV; ME20M; gp100; ME20-M; PMEL17; D12S53E; melanocyte protein PMEL; melanocyte protein mel 17; silver, mouse, homolog of; melanocyte protein Pmel 17; melanosomal matrix protein17; silver locus protein homolog; melanoma-associated ME20 antigen; melanocytes lineage-specific antigen GP100;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • C
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PMEL-190H Recombinant Human PMEL protein, MYC/DDK-tagged HEK293 Myc/DDK
Human PMEL-30194TH Recombinant Human PMEL E.coli N/A
Human PMEL-191H Recombinant Human PMEL Protein, GST-tagged Wheat Germ GST
Human PMEL-1518H Recombinant Human PMEL Protein (25-467 aa), His-tagged Yeast His 25-467 aa
Human PMEL-3492H Recombinant Human PMEL protein, His-SUMO-tagged E.coli His-SUMO 25-467aa
Human PMEL-2601H Recombinant Human PMEL Protein, His-tagged E.coli N-His Gln470-Val661
Human PMEL-1717H Recombinant Human PMEL Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PMEL-6849HF Recombinant Full Length Human PMEL Protein, GST-tagged In Vitro Cell Free System GST 661 amino acids
Human PMEL-01H Recombinant Human PMEL Protein, Tag Free E.coli Tag Free
Human PMEL-835HFL Recombinant Full Length Human PMEL Protein, C-Flag-tagged Mammalian cells Flag
Human PMEL-1717H-B Recombinant Human PMEL Protein Pre-coupled Magnetic Beads HEK293
Human PMEL-2756H Recombinant Human PMEL protein(371-440 aa), C-His-tagged E. coli C-His 371-440 aa
Mouse Pmel-4952M Recombinant Mouse Pmel Protein, Myc/DDK-tagged HEK293T Myc/DDK
Chicken PMEL-6669C Recombinant Chicken PMEL Mammalian Cell His
  • PMEL Related Articles

PMEL involved in several pathways and played different roles in them. We selected most pathways PMEL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PMEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein

PMEL has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PMEL itself. We selected most functions PMEL had, and list some proteins which have the same functions with PMEL. You can find most of the proteins on our site.

Function Related Protein

PMEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMEL here. Most of them are supplied by our site. Hope this information will be useful for your research of PMEL.

Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).
Pentcheva-Hoang, T; Simpson, TR; et al. Cytotoxic T Lymphocyte Antigen-4 Blockade Enhances Antitumor Immunity by Stimulating Melanoma-Specific T-cell Motility. CANCER IMMUNOLOGY RESEARCH 2:970-980(2014).
  • Q&As
  • Reviews

Q&As (4)

Ask a question
Do you offer PMEL fused with other tags? 03/12/2022

We will provide you with the most suitable labels according to your needs.

What are the consequences of PMEL gene deletion? 11/12/2021

Animals with PMEL gene deletions exhibit varying degrees of hyperpigmentation.

What are the main physiological processes in which PMEL proteins are involved? 07/01/2021

PMEL proteins play an important role in melanin synthesis and storage.

In what tissue of the duck is the PMEL protein primarily expressed? 04/11/2021

PMEL proteins are predominantly expressed in the hair follicles and skin of ducks.

Customer Reviews (3)

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Reviews
08/16/2022

    Your company offers a one-stop shop and the process from purchase to receipt of the protein was very smooth!

    07/14/2022

      The purchased PMEL protein is suitable for WB experiments and I am satisfied with the results.

      10/22/2020

        Friendly customer service and detailed answers to all the questions I asked!

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