PMEL
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Official Full Name
premelanosome protein -
Overview
This gene encodes a melanocyte-specific type I transmembrane glycoprotein. The encoded protein is enriched in melanosomes, which are the melanin-producing organelles in melanocytes, and plays an essential role in the structural organization of premelanosomes. This protein is involved in generating internal matrix fibers that define the transition from Stage I to Stage II melanosomes. This protein undergoes a complex pattern of prosttranslational processing and modification that is essential to the proper functioning of the protein. A secreted form of this protein that is released by proteolytic ectodomain shedding may be used as a melanoma-specific serum marker. Alternate splicing results in multiple transcript variants. -
Synonyms
PMEL;premelanosome protein;P1;SI;SIL;ME20;P100;SILV;ME20M;gp100;ME20-M;PMEL17;D12S53E;melanocyte protein PMEL;melanocyte protein mel 17;silver, mouse, homolog of;melanocyte protein Pmel 17;melanosomal matrix protein17;silver locus protein homolog;melanoma-associated ME20 antigen;melanocytes lineage-specific antigen GP100
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Yeast
- HEK293
- Mammalian Cells
- Wheat Germ
- In Vitro Cell Free System
- Non
- His
- DDK
- Myc
- Avi
- Fc
- GST
- SUMO
- Flag
Involved Pathway
PMEL involved in several pathways and played different roles in them. We selected most pathways PMEL participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PMEL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PMEL has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by PMEL itself. We selected most functions PMEL had, and list some proteins which have the same functions with PMEL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
PMEL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PMEL here. Most of them are supplied by our site. Hope this information will be useful for your research of PMEL.
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References
- Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).
- Pentcheva-Hoang, T; Simpson, TR; et al. Cytotoxic T Lymphocyte Antigen-4 Blockade Enhances Antitumor Immunity by Stimulating Melanoma-Specific T-cell Motility. CANCER IMMUNOLOGY RESEARCH 2:970-980(2014).
