Recombinant Human PMEL Protein (25-467 aa), His-tagged PMEL-1518H

Recombinant Human PMEL Protein (25-467 aa), His-tagged

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Recombinant Human PMEL Protein (25-467 aa), His-tagged

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Cat.No. : PMEL-1518H
Product Overview : Recombinant Human PMEL Protein (25-467 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Metabolism. Protein Description: Partial.
Description : Plays a central role in the biogenesis of melanosomes. Involved in the maturation of melanosomes from stage I to II. The transition from stage I melanosomes to stage II melanosomes involves an elongation of the vesicle, and the appearance within of distinct fibrillar structures. Release of the soluble form, ME20-S, could protect tumor cells from antibody mediated immunity.
Source : Yeast
Species : Human
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 49.0 kDa
Protein length : 25-467 aa
AA Sequence : KVPRNQDWLG VSRQLRTKAW NRQLYPEWTE AQRLDCWRGG QVSLKVSNDG PTLIGANASF SIALNFPGSQ KVLPDGQVIW VNNTIINGSQ VWGGQPVYPQ ETDDACIFPD GGPCPSGSWS QKRSFVYVWK TWGQYWQVLG GPVSGLSIGT GRAMLGTHTM EVTVYHRRGS RSYVPLAHSS SAFTITDQVP FSVSVSQLRA LDGGNKHFLR NQPLTFALQL HDPSGYLAEA DLSYTWDFGD SSGTLISRAL VVTHTYLEPG PVTAQVVLQA AIPLTSCGSS PVPGTTDGHR PTAEAPNTTA GQVPTTEVVG TTPGQAPTAE PSGTTSVQVP TTEVISTAPV QMPTAESTGM TPEKVPVSEV MGTTLAEMST PEATGMTPAE VSIVVLSGTT AAQVTTTEWV ETTARELPIP EPEGPDASSI MSTESITGSL GPLLDGTATL RLV
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : PMEL premelanosome protein [ Homo sapiens ]
Official Symbol : PMEL
Synonyms : PMEL; D12S53E; gp100; Pmel17; SI; P1; SIL; ME20; P100; SILV; ME20M; ME20-M; PMEL17;
Gene ID : 6490
mRNA Refseq : NM_001200053
Protein Refseq : NP_001186982
MIM : 155550
UniProt ID : P40967

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