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PON1

  • Official Full Name

    paraoxonase 1

  • Overview

    Serum paraoxonase/arylesterase 1 (PON1) also known as aromatic esterase 1 or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.
  • Synonyms

    PON1; ESA; MVCD5; PON; A-esterase 1; K-45; PON 1; aromatic esterase 1; arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1; paraoxonase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Mammalian cells
  • Trichoplusia Ni Larval
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • Fc
  • SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PON1-01H Active Recombinant Human PON1 Protein, His-tagged HEK293 His 16-355
Human PON1-49H Recombinant Human PON1, His-tagged E.coli His
Human PON1-06H Recombinant Human PON1, His-tagged Trichoplusia Ni Larval His
Human PON1-07H Recombinant Human PON1, His-tagged E.coli His Gln35~Val206
Human PON1-3014HCL Recombinant Human PON1 293 Cell Lysate HEK293 N/A
Human PON1-732H Recombinant Human PON1 Protein (2-355 aa), GST-tagged E.coli GST 2-355 aa
Human PON1-33H Recombinant Human PON1 Protein, MYC/DDK-tagged HEK293T Myc/DDK
Human PON1-3249H Recombinant Human PON1 protein, His-tagged E.coli His Ala2~Leu355
Human PON1-32H Active Recombinant Human PON1 Protein, His/Fc-tagged HEK293 His/Fc
Human PON1-3299H Recombinant Human PON1 protein, His-GST-tagged E.coli His/GST Ala2~Leu355
Human PON1-1899H Recombinant Human PON1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human PON1-3300H Recombinant Human PON1 protein, His-SUMO-tagged E.coli His-SUMO Ala2~Leu355
Human PON1-499HFL Recombinant Full Length Human PON1 Protein, C-Flag-tagged Mammalian cells Flag
Human PON1-3301H Recombinant Human PON1 protein, His-tagged E.coli His Ala2~Leu355
Human PON1-1733H Recombinant Human PON1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human PON1-1733H-B Recombinant Human PON1 Protein Pre-coupled Magnetic Beads HEK293
Mouse PON1-13122M Recombinant Mouse PON1 Protein Mammalian Cell His
Mouse Pon1-292M Recombinant Mouse Pon1 Protein, His-tagged E.coli His Ala187~Asp354
Mouse Pon1-293M Recombinant Mouse Pon1 Protein, His-tagged E.coli His Ala2~Phe186
Mouse PON1-6940M Recombinant Mouse PON1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Pon1-5013M Recombinant Mouse Pon1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Pon1-4059M Recombinant Mouse Pon1 protein E.coli N/A 2-355aa
Mouse PON1-6940M-B Recombinant Mouse PON1 Protein Pre-coupled Magnetic Beads HEK293
Rat Pon1-294R Recombinant Rat Pon1 Protein, His-tagged E.coli His Ala2~Phe186
Rat PON1-4577R Recombinant Rat PON1 Protein Mammalian Cell His
Rat PON1-3305R Recombinant Rat PON1 protein, His-SUMO-tagged E.coli His-SUMO Ala2~Leu355
Rat PON1-4237R-B Recombinant Rat PON1 Protein Pre-coupled Magnetic Beads HEK293
Rat PON1-4237R Recombinant Rat PON1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PON1-3304R Recombinant Rat PON1 protein, His-GST-tagged E.coli His/GST Ala2~Leu355
Rat PON1-3306R Recombinant Rat PON1 protein, His-tagged E.coli His Ala2~Leu355
Zebrafish PON1-1266Z Recombinant Zebrafish PON1 Mammalian Cell His
Kit-1109 Paraoxonase 1 (PON1) Activity Assay Kit (Fluorometric) N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PON1 Related Articles
  • PON1 Related Research Area

PON1 involved in several pathways and played different roles in them. We selected most pathways PON1 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Metabolic pathwaysTPH2;ITGB1BP3;LASS5;FBP1A;ITPKC;G6PCA.2;MTMR1B;HADHAA;AANAT1

PON1 has several biochemical functions, for example, aryldialkylphosphatase activity, arylesterase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PON1 itself. We selected most functions PON1 had, and list some proteins which have the same functions with PON1. You can find most of the proteins on our site.

Function Related Protein
aryldialkylphosphatase activityPON1;PON3
arylesterase activityCA1;PON3;CA2;APMAP;PON2;C20orf3;PON1;CAR1;Car2
calcium ion bindingPLCD1;PCDH1G26;CDH4;PCDH1G29;DUOX2;RAB11FIP4A;MATN3;PCDHGA2;CAPNS1B
phospholipid bindingAPOA2;ANXA1;APOEA;BIN2;PICALMA;PLA2G2A;PLA2G15;LPAR3;NBEA
protein homodimerization activityPLCB1;UGT1A6A;TGFB2;NR2F2;PLD6;PVRL1A;UGT1A3;RXRB;ADIPOQ

PON1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON1.

d-mannose

Shahmohamadnejad, S; Vaisi-Raygani, A; et al. Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: Correlation with systemic inflammatory markers and oxidative stress, preliminary report. CLINICAL BIOCHEMISTRY 48:63-69(2015).
Bednarska-Makaruk, M; Rodo, M; et al. Paraoxonase 1 activity and level of antibodies directed against oxidized low density lipoproteins in a group of an elderly population in Poland - PolSenior study. ARCHIVES OF GERONTOLOGY AND GERIATRICS 60:153-161(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any genetic tests available to assess PON1 activity? 08/17/2022

Yes, genetic tests can determine an individual's PON1 genotype and predict their enzyme activity.

Can PON1 activity be influenced by genetics? 07/30/2022

Yes, PON1 activity can be influenced by genetic variations, leading to different enzyme levels and activity.

How is PON1 linked to the metabolism of drugs and xenobiotics? 08/20/2019

PON1 can hydrolyze and detoxify certain drugs and environmental toxins, making it important in drug metabolism.

Can PON1 be used to assess an individual's susceptibility to organophosphate toxicity? 02/26/2019

Yes, PON1 activity levels can help predict an individual's susceptibility to organophosphate toxicity.

How is PON1 associated with atherosclerosis and heart disease? 05/04/2017

PON1 protects against atherosclerosis by preventing the oxidation of LDL cholesterol, a key factor in heart disease.

Customer Reviews (3)

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Reviews
02/06/2022

    The manufacturer's team of experts possesses a deep understanding of the PON1 protein and its associated protocols.

    07/20/2020

      This high-quality PON1 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations

      04/27/2019

        In conclusion, using PON1 protein in trials offers distinct advantages for researchers studying cell cycle regulation.

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