pon1
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  • Official Full Name
  • paraoxonase 1
  • Background
  • Serum paraoxonase/arylesterase 1 (PON1) also known as aromatic esterase 1 or serum aryldialkylphosphatase 1 is an enzyme that in humans is encoded by the PON1 gene. Paraoxonase 1 has esterase and more specifically paraoxonase activity. PON1 is responsible for hydrolysing organophosphate pesticides and nerve gasses. Polymorphisms in the PON1 gene significantly affect the catalytic ability of the enzyme. PON1 (paraoxonase 1) is also a major anti-atherosclerotic component of high-density lipoprotein (HDL). The PON1 gene is activated by PPAR-γ, which increases synthesis and release of paraoxonase 1 enzyme from the liver, reducing atherosclerosis.
  • Synonyms
  • PON1; ESA; MVCD5; PON; A-esterase 1; K-45; PON 1; aromatic esterase 1; arylesterase B-type; esterase A; paraoxonase B-type; serum aryldiakylphosphatase; serum aryldialkylphosphatase 1; serum paraoxonase/arylesterase 1; paraoxonase 1
Cat.#:PON1-33HTag:Myc|DDK
Source (Host):HEK293TSpecies:Human
Product nameRecombinant Human PON1 Protein, MYC/DDK-tagged
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Cat.#:PON1-732HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PON1 Protein (2-355 aa), GST-tagged
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Cat.#:PON1-06HTag:His
Source (Host):Trichoplusia ni larval expression systemSpecies:Human
Product nameRecombinant Human PON1, His-tagged
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Cat.#:PON1-07HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PON1, His-tagged
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Cat.#:PON1-49HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PON1, His-tagged
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Cat.#:PON1-13122MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PON1 Protein
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Cat.#:Pon1-292MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pon1 Protein, His-tagged
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Cat.#:Pon1-293MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pon1 Protein, His-tagged
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Cat.#:Pon1-294RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Pon1 Protein, His-tagged
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Cat.#:PON1-4577RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PON1 Protein
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Cat.#:PON1-1266ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PON1
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Cat.#:PON1-3014HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PON1 293 Cell Lysate
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Cat.#:Kit-1109Tag:N/A
Source (Host):Species:
Product nameParaoxonase 1 (PON1) Activity Assay Kit (Fluorometric)
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Involved Pathway

PON1 involved in several pathways and played different roles in them. We selected most pathways PON1 participated on our site, such as Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PON1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Metabolic pathways
Ckmm; NADKA; ATP6V0A1B; ADA; NAPRT; EPRS; MAN1B1; PIGX; DCT; AMY2A3

Protein Function

PON1 has several biochemical functions, for example, aryldialkylphosphatase activity, arylesterase activity, calcium ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PON1 itself. We selected most functions PON1 had, and list some proteins which have the same functions with PON1. You can find most of the proteins on our site.
Function
Related Protein
Function aryldialkylphosphatase activity
Related Protein PON3; PON1
Function arylesterase activity
Related Protein Car2; CA2; APMAP; CA1; C20orf3; PON1; PON3; CAR1; PON2
Function calcium ion binding
Related Protein ANXA1A; PCDH2G12; SYTL2; THBS3; S100A13; PCDH11Y; FSTL4; SLC25A13; CDH11; SLC25A25
Function phospholipid binding
Related Protein PICALMA; APOEA; NR5A1; SYT14; SMURF1; PICALMB; APOH; PTAFR; PLA2G2A; GRK5
Function protein homodimerization activity
Related Protein LSM1; SERPINF2; PVRL4; TMEM173; GHR; CER1; SNX9; PYCARD; ASGR1; CHMP4A

Interacting Protein

PON1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PON1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PON1.
d-mannose

PON1 Related Articles

Shahmohamadnejad, S; Vaisi-Raygani, A; et al. Association between butyrylcholinesterase activity and phenotypes, paraoxonase192 rs662 gene polymorphism and their enzymatic activity with severity of rheumatoid arthritis: Correlation with systemic inflammatory markers and oxidative stress, preliminary report. CLINICAL BIOCHEMISTRY 48:63-69(2015).
Bednarska-Makaruk, M; Rodo, M; et al. Paraoxonase 1 activity and level of antibodies directed against oxidized low density lipoproteins in a group of an elderly population in Poland - PolSenior study. ARCHIVES OF GERONTOLOGY AND GERIATRICS 60:153-161(2015).