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Recombinant Human PON1 Protein (2-355 aa), GST-tagged

Cat.No. : PON1-732H
Product Overview : Recombinant Human PON1 Protein (2-355 aa) is produced by E. coli expression system. This protein is fused with a GST tag at the N-terminal. Research Area: Cardiovascular. Protein Description: Full Length of Mature Protein.
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Description : Hydrolyzes the toxic metabolites of a variety of organophosphorus insecticides. Capable of hydrolyzing a broad spectrum of organophosphate substrates and lactones, and a number of aromatic carboxylic acid esters. Mediates an enzymatic protection of low density lipoproteins against oxidative modification and the consequent series of events leading to atheroma formation.
Source : E. coli
Species : Human
Tag : GST
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 66.6 kDa
Protein length : 2-355 aa
AA Sequence : AKLIALTLLGMGLALFRNHQSSYQT RLNALREVQPVELPNCNLVKGIETG SEDLEILPNGLAFISSGLKYPGIKS FNPNSPGKILLMDLNEEDPTVLELG ITGSKFDVSSFNPHGISTFTDEDNA MYLLVVNHPDAKSTVELFKFQEEEK SLLHLKTIRHKLLPNLNDIVAVGPE HFYGTNDHYFLDPYLQSWEMYLGLA WSYVVYYSPSEVRVVAEGFDFANGI NISPDGKYVYIAELLAHKIHVYEKH ANWTLTPLKSLDFNTLVDNISVDPE TGDLWVGCHPNGMKIFFYDSENPPA SEVLRIQNILTEEPKVTQVYAENGT VLQGSTVASVYKGKLLIGTVFHKAL YCEL
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : PON1 paraoxonase 1 [ Homo sapiens ]
Official Symbol : PON1
Synonyms : PON1; PON; ESA; K-45; PON 1; MVCD5;
Gene ID : 5444
mRNA Refseq : NM_000446
Protein Refseq : NP_000437
UniProt ID : P27169

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (5)

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Are there any genetic tests available to assess PON1 activity? 08/17/2022

Yes, genetic tests can determine an individual's PON1 genotype and predict their enzyme activity.

Can PON1 activity be influenced by genetics? 07/30/2022

Yes, PON1 activity can be influenced by genetic variations, leading to different enzyme levels and activity.

How is PON1 linked to the metabolism of drugs and xenobiotics? 08/20/2019

PON1 can hydrolyze and detoxify certain drugs and environmental toxins, making it important in drug metabolism.

Can PON1 be used to assess an individual's susceptibility to organophosphate toxicity? 02/26/2019

Yes, PON1 activity levels can help predict an individual's susceptibility to organophosphate toxicity.

How is PON1 associated with atherosclerosis and heart disease? 05/04/2017

PON1 protects against atherosclerosis by preventing the oxidation of LDL cholesterol, a key factor in heart disease.

Customer Reviews (3)

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Reviews
02/06/2022

    The manufacturer's team of experts possesses a deep understanding of the PON1 protein and its associated protocols.

    07/20/2020

      This high-quality PON1 protein provides researchers with confidence in obtaining accurate and reliable data during their investigations

      04/27/2019

        In conclusion, using PON1 protein in trials offers distinct advantages for researchers studying cell cycle regulation.

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