ppp1ca
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  • Official Full Name
  • protein phosphatase 1, catalytic subunit, alpha isozyme
  • Background
  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme; PPP1A, protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP 1A; PP1alpha; protein phosphatase 1, catalytic subunit,
Cat.#:PPP1CA-1015HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-27568THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-31049THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-13209MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP1CA Protein
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Cat.#:PPP1CA-4611RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP1CA Protein
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Cat.#:PPP1CA-2951HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Cat.#:PPP1CA-2952HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Cat.#:PPP1CA-2953HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Involved Pathway

PPP1CA involved in several pathways and played different roles in them. We selected most pathways PPP1CA participated on our site, such as mRNA surveillance pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
PABPC1A; RBM8A; BAT1; PELO; PPP2CA; PPP2R5E; UPF3B; PPP2R5EA; WIBG; SMG7
cGMP-PKG signaling pathway
TRPC6; CALM2; GNAI1; PIK3CB; PPP3CC; VDAC1; KCNMB3; PRKG1; Adcy4; CALM4
cAMP signaling pathway
ATP1B1; PPP1CB; ATP1A4; MAPK3; GHRL; RAP1B; GRIN3B; PDE3A; CREB5; CNGA1
Oocyte meiosis
SGOL1; PPP3CCA; INS2; RPS6KA6; CALML5; PTTG1; FBXO43; CTH1; INS; CUL1A
Adrenergic signaling in cardiomyocytes
MAPK14A; ADCY2B; CACNA1C; PPP1CAA; SCN5A; GNA11A; PPP1CBL; GNAI2; ATP1A2; ATP1A3B
Vascular smooth muscle contraction
PPP1R12B; PPP1CAA; MYLK; KCNMB4; PLA2G2D; CALM2A; PLA2G2F; CACNA1SB; PPP1R14AB; ACTG2
Hippo signaling pathway
BTRC; WNT8A; SCRIB; CCND2; CCND3; GDF5; BMP7; CTNNA3; JUB; WNT3A
Focal adhesion
CAPN2B; PPP1CAA; PIK3R1; MAPK6; VEGFC; PDGFA; BADB; TNW; THBS3A; LAMB1A
Platelet activation
F2R; COL24A1; VWF; MYLK; PIK3CB; PIK3R5; MAPK13; MYL12A; TLN1; PRKCZ
Long-term potentiation
RAP1A; PRKCB; PPP3CC; CALM4; GRIA2; PLCB1; MAP2K1; PPP3R2; ITPR1; CALM2
Dopaminergic synapse
CREB5; CALML5; AKT2; GRIA1; CAMK2B; PPP2R2D; GNAS; KCNJ6; CALM2; ATF6B
Inflammatory mediator regulation of TRP channels
PRKCQ; CYP2C38; PLCB3; PLCB2; CYP2C70; GNAQ; PLA2G4A; PPP1CB; MAPK11; PTGER2
Regulation of actin cytoskeleton
NCKAP1L; CYFIP2; PAK1; RAC2; FGF12A; PIK3R3B; PTK2AB; HRAS; PFN1; FGD3
Insulin signaling pathway
INS1; CALM2; INPPL1A; INS; PIK3R1; SOCS9; G6PC3; CALML5; SOCS3; TSC2
Oxytocin signaling pathway
RGS2; FOS; GNAI3; Adcy4; CAMK2G; CALM1; SRC; MYLK3; PIK3CA; PPP3CC
Insulin resistance
PDPK1; PPP1R3D; INSRB; PTPRF; PRKAB1; SLC2A1; GYS1; CRTC2; FOXO1B; G6PC3
Amphetamine addiction
GRIA4; PPP3CB; SLC6A3; ATF4; CAMK4; FOSB; ARC; CAMK2B; PPP1CB; CREB3L1
Alcoholism
H2AFJ; GNGT1; HIST1H2AP; HIST1H4D; HIST2H3A; CREB3L3; HIST1H3E; NPY; HAT1; RAF1
Herpes simplex infection
HLA-DQA1; ARNTL1A; TP53; IFNG1-2; Fasl; IFNA12; SRSF7; ARNTL1B; IL12BA; HLA-DQB1
Proteoglycans in cancer
ITGA5; FZD7; TLR4; PDCD4; TWIST2; WNT8B; FZD2; HSPB2; AKT1; CBLC

Protein Function

PPP1CA has several biochemical functions, for example, ATP binding, GTP binding, butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CA itself. We selected most functions PPP1CA had, and list some proteins which have the same functions with PPP1CA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein CAMKK1A; MYO3B; SNRK; RAD51C; EPHB4; PRKCA; MYH13; DCLK3; UBE2A; EPB42
Function GTP binding
Related Protein GMPPAB; EEF2A.1; RSG1; EIF5B; RAB34; DIRAS1A; RAB3D; ARL8; RHOGC; ARL13A
Function butyrate-CoA ligase activity
Related Protein ACSM3; ACSM1; ACSM5; Acsm2a; ACSM4; ACSM2; ACSM2B; PPP1CA; AACS
Function metal ion binding
Related Protein ALKBH5; ZFC3H1; ITK; SRSF7A; ZFAND5B; GLI2A; LRP2; MLPH; ALOX5A; KCND3

Interacting Protein

PPP1CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CA.
TP53BP2; CSRNP2; RB1; PPP1R13B