ppp1ca
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  • Official Full Name
  • protein phosphatase 1, catalytic subunit, alpha isozyme
  • Background
  • The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms
  • PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme; PPP1A, protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP 1A; PP1alpha; protein phosphatase 1, catalytic subunit,
Cat.#:PPP1CA-2523DTag:His/Myc
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog PPP1CA Protein (2-330 aa), His-Myc-tagged
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Cat.#:PPP1CA-1015HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-27568THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-31049THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP1CA, His-tagged
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Cat.#:PPP1CA-13209MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP1CA Protein
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Cat.#:PPP1CA-4611RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP1CA Protein
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Cat.#:PPP1CA-2951HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Cat.#:PPP1CA-2952HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Cat.#:PPP1CA-2953HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP1CA 293 Cell Lysate
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Involved Pathway

PPP1CA involved in several pathways and played different roles in them. We selected most pathways PPP1CA participated on our site, such as mRNA surveillance pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
RBM8A; NCBP2; PPP2R3C; MSI1; SRRM1; CPSF3; RNGTT; PPP2R1A; GSPT1L; WDR82
cGMP-PKG signaling pathway
GTF2IRD1; SLC25A6; MYLK; MYLK4; CALML5; PLCB4; NOS3; PDE3B; PIK3CD; GNAI3
cAMP signaling pathway
PPP1CC; MAPK9; TSHR; CAMK2G; ATP1A1; PIK3R5; BAD; PTGER3; PTGER2; DRD1A
Oocyte meiosis
CDC23; CDC27; YWHAE; PPP3CC; MAPK3; PPP2R5D; SPDYA; INS2; PPP2R1B; CALM1
Adrenergic signaling in cardiomyocytes
PRKACG; CALML3; MAPK13; PIK3R2; PPP2R5EA; CACNB3A; BCL2A; GNAIA; SCN1B; PPP2R5EB
Vascular smooth muscle contraction
RHOA; PRKCDA; PPP1R14AA; ITPR3; PRKACB; MYL12.1; KCNMA1A; PPP1CAA; PLA2G2F; NPR2
Hippo signaling pathway
AJUBA; WWTR1; DLG1; ID1; GSK3B; STK3; FZD2; SERPINE1; AXIN1; SAV1
Focal adhesion
ITGB5; SOS1; CDC42L; ITGB3B; PPP1R12B; TNR; PPP1CA; PDGFAB; SHC1; IGF1R
Platelet activation
GP1BA; PRKG1; MYLK4; ARHGEF1; PPP1R12A; PLA2G4F; LCP2; TBXAS1; FCGR2A; ARHGAP35
Long-term potentiation
GRIN2B; MAP2K1; PPP3R1; PRKACB; PPP1CA; RAF1; PRKACG; GRIA2; ATF4; KRAS
Dopaminergic synapse
PPP2R3C; PLCB4; PRKCA; GNG5; PPP3CC; GNG10; PPP2R5C; ARRB2; KIF5B; MAPK8
Inflammatory mediator regulation of TRP channels
ACCN4; PLCB2; ASIC2; NTRK1; IGF1; KLK1B4; CALM4; CYP2C70; PIK3CB; CYP2J6
Regulation of actin cytoskeleton
ITGB1; CD14; ARHGEF7B; LIMK2; ABI2; VAV3; WASF1; ACTN3A; ABI2B; FGF8A
Insulin signaling pathway
GSK3AA; G6PC; FOXO1; SOS1; G6PC3; PDE3B; PRKAB2; MAPK8A; INS; MAPK10
Oxytocin signaling pathway
PRKAG1; RYR1; CAMK1; GNAI3; RAF1; PLA2G4D; CALM1; CACNG8; ITPR3; PIK3CD
Insulin resistance
PRKCE; MTOR; PYGB; PTPRF; AKT2; PPP1CC; CREB3L3A; GFPT2; PIK3CB; AKT1
Amphetamine addiction
CREB3; CREB3L2; GRIA4; GRIN2B; PPP3CB; CREB3L3; GNAS; FOS; CALM2; CAMK2B
Alcoholism
HDAC5; HIST1H4K; HIST1H3E; MAPK1; GNAO1; HIST1H3G; HIST2H2AC; HDAC8; GM6026; MAP2K1
Herpes simplex infection
HLA-DPA1; SFRS3B; EEF1DA; Casp3; EEF1DB; TAP2; NFKB1; RNASEL; THOC4; CUL1
Proteoglycans in cancer
EZR; WNT7B; TNF; RRAS; MTOR; PRKCA; PPP1R12A; SMAD2; DROSHA; FZD10

Protein Function

PPP1CA has several biochemical functions, for example, ATP binding, GTP binding, butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CA itself. We selected most functions PPP1CA had, and list some proteins which have the same functions with PPP1CA. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein PCCB; EPHB1; TLK1A; CAMKK1; BMPR2A; HSPA6; TTF2; BBS10; MARK3; TYK2
Function GTP binding
Related Protein SEPT6; EHD3; RAB2A; RHOT1B; IRGC; ARL8BA; RAB40C; RAB41; TUBAL3; GUCY2E
Function butyrate-CoA ligase activity
Related Protein ACSM2B; ACSM4; PPP1CA; Acsm2a; ACSM2; ACSM3; ACSM1; ACSM5; AACS
Function metal ion binding
Related Protein MUSK; ZSCAN2; ZNF10; ZNF256; ROCK2A; ZNF565; ARAP3; AGFG2; ZHX2; COL3A1

Interacting Protein

PPP1CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CA.
TP53BP2; CSRNP2; RB1; PPP1R13B