PPP1CA Protein, protein phosphatase 1, catalytic subunit, alpha isozyme


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Official Full Name protein phosphatase 1, catalytic subunit, alpha isozyme
Background The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Synonyms PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme; PPP1A, protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP 1A; PP1alpha; protein phosphatase 1, catalytic subunit,
    • Species :
    • Dog
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Tag :
    • His
    • Myc
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Dog PPP1CA-2523D Recombinant Dog PPP1CA Protein (2-330 aa), His-Myc-tagged E.coli His/Myc
    Human PPP1CA-1015H Recombinant Human PPP1CA, His-tagged Human His
    Human PPP1CA-27568TH Recombinant Human PPP1CA, His-tagged E.coli His
    Human PPP1CA-2951HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
    Human PPP1CA-2952HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
    Human PPP1CA-2953HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
    Human PPP1CA-31049TH Recombinant Human PPP1CA, His-tagged E.coli His
    Mouse PPP1CA-13209M Recombinant Mouse PPP1CA Protein Mammalian Cell His
    Rat PPP1CA-4611R Recombinant Rat PPP1CA Protein Mammalian Cell His

    PPP1CA involved in several pathways and played different roles in them. We selected most pathways PPP1CA participated on our site, such as mRNA surveillance pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway SMG5; UPF1; SMG7; MSI1; PABPC3; CPSF1; PPP2R3A; PABPC1B; PABPC1L2A; SRRM1
    cGMP-PKG signaling pathway PLCB1; PPP3CA; NFATC1; CREB3L3; PDE2A; GUCY1B3; NPR2; LOC100328615; INS; ATP2B1
    cAMP signaling pathway GRIN1; BRAF; ARAP3; CAMK2G; PPP1R12A; SUCNR1; RELA; CNGA1; GNAI1; GLI1
    Oocyte meiosis PGR; RPS6KA3; CDC26; RPS6KA6; YWHABA; CAMK2D; MAPK1; CUL1A; RPS6KA3B; REC8
    Adrenergic signaling in cardiomyocytes TPMA; ADRA1D; CREM; TNNC1A; PRKACAB; PPP2R5EA; PRKCA; BCL2A; CREB3L1; ATP2A2
    Vascular smooth muscle contraction PRKCH; CALM1A; CYP4A12A; PRKACBA; CALM3; PLA2G3; NPR1A; CYP4A14; CALM2; NPR1
    Hippo signaling pathway BTRC; RASSF1; SERPINE1; FGF1; TGFB3; FZD1; GDF7; PPP1CB; WNT16; GDF6
    Platelet activation PIK3R5; FGG; FERMT3; VWF; P2RY1; ARHGEF12; AKT1; GNAI3; PIK3CA; RAP1A
    Long-term potentiation RAP1B; GRIN2C; PRKACG; CALML3; KRAS; CAMK2A; RAF1; GRIA1; PRKCG; PRKACA
    Dopaminergic synapse KIF5A; KCNJ3; GRIA2; GRIA1; GNAS; PRKACG; PPP2CB; DRD5; FOS; PPP1CA
    Inflammatory mediator regulation of TRP channels PPP1CB; PTGER2; NGF; PIK3R3; HTR2B; PLCB2; ACCN4; MAPK9; PLCB4; CYP2J2
    Regulation of actin cytoskeleton ACTB2; RHOAA; ROCK2B; IQGAP2; ARAF; ITGA4; PTK2; ACTN3A; PDGFRA; WASLB
    Insulin signaling pathway LIPE; RAF1; PIK3CB; HK3; PYGL; BAD; RHOQ; CBLB; PRKACG; PRKAG3B
    Oxytocin signaling pathway RYR3; PLCB1; RGS2; PPP3CC; CACNG7; PLA2G4F; MEF2C; NPR1; RCAN1; CD38
    Insulin resistance INSRB; AKT2L; TRIB3; SLC27A3; GFPT2; PPP1CBL; PPP1R3D; PRKAB2; PIK3R3A; PPP1CC
    Amphetamine addiction JUN; STX1A; MAOA; CREB3L4; FOS; CAMK2G; PRKACA; PPP1CC; PRKACB; CAMK4
    Herpes simplex infection PER1; IFNA4; C3; IFNA3; TBK1; NFKBIAB; TRAF5; PER1A; SRSF5A; ABCB3L1
    Proteoglycans in cancer HSPG2; TWIST2; WNT6; PPP1CA; DROSHA; TGFB2; FLNC; TP53; HPSE; MAPK1

    PPP1CA has several biochemical functions, for example, ATP binding, GTP binding, butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CA itself. We selected most functions PPP1CA had, and list some proteins which have the same functions with PPP1CA. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding NME2B.1; UBE2Q2; HSPA1L; KIF15; TRAP1; ATP1A1A.4; PFKFB4; MAP2K4A; KIF27; DGKA
    GTP binding RABL5; ARL4D; RIT2; GNAT1; RALB; DNAJC27; RAB12; RAB42A; FPGT; GNA13B
    butyrate-CoA ligase activity ACSM2B; ACSM5; ACSM1; ACSM4; AACS; ACSM3; PPP1CA; Acsm2a; ACSM2
    metal ion binding SMAD5; HE1A; CYP2J5; Scd1; KLF8; TPH1B; ZFP326; NUBP2; GLI4; SMYD3

    PPP1CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CA.

    TP53BP2; CSRNP2; RB1; PPP1R13B

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