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PPP1R2

  • Official Full Name

    protein phosphatase 1, regulatory (inhibitor) subunit 2

  • Overview

    Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene.
  • Synonyms

    PPP1R2; protein phosphatase 1, regulatory (inhibitor) subunit 2; protein phosphatase inhibitor 2; IPP2; phosphatase inhibitor 2; phosphoprotein phosphatase; IPP-2; MGC87148;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPP1R2-29472TH Recombinant Human PPP1R2 Wheat Germ N/A 205 amino acids
Human PPP1R2-2438H Recombinant human PPP1R2, His-tagged E.coli His
Human PPP1R2-1908H Recombinant Human PPP1R2, GST-tagged E.coli GST 1-205AA
Human PPP1R2-31217TH Recombinant Human PPP1R2 Wheat Germ N/A 100 amino acids
Human PPP1R2-2937HCL Recombinant Human PPP1R2 293 Cell Lysate HEK293 N/A
Human PPP1R2-391HF Recombinant Full Length Human PPP1R2 Protein In Vitro Cell Free System 205 amino acids
Human PPP1R2-3291H Recombinant Human PPP1R2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse PPP1R2-13231M Recombinant Mouse PPP1R2 Protein Mammalian Cell His
Mouse PPP1R2-7016M-B Recombinant Mouse PPP1R2 Protein Pre-coupled Magnetic Beads HEK293
Mouse Ppp1r2-5071M Recombinant Mouse Ppp1r2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse PPP1R2-7016M Recombinant Mouse PPP1R2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPP1R2-4622R Recombinant Rat PPP1R2 Protein Mammalian Cell His
Rat PPP1R2-4281R Recombinant Rat PPP1R2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPP1R2-4281R-B Recombinant Rat PPP1R2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PPP1R2-3567R Recombinant Rhesus monkey PPP1R2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PPP1R2-3385R Recombinant Rhesus Macaque PPP1R2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PPP1R2-3385R-B Recombinant Rhesus Macaque PPP1R2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PPP1R2-11693Z Recombinant Zebrafish PPP1R2 Mammalian Cell His
Chicken PPP1R2-2967C Recombinant Chicken PPP1R2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PPP1R2 Related Articles

PPP1R2 involved in several pathways and played different roles in them. We selected most pathways PPP1R2 participated on our site, such as Androgen biosynthesis, Metabolism, Metabolism of lipids and lipoproteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1R2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Androgen biosynthesisCGA;POMCB;PPP1R2;CYP17A1
MetabolismMED9;SAT1B;ACOT11A;SACM1LA;MED15;MED22;SLC25A20;PDZD11;CHST14
Metabolism of lipids and lipoproteinsPMVK;CPT2;CYP2AD3;ANKRD1;FAM213B;CDS1;CYP8B2;CERS4A;CERS3B
Metabolism of steroid hormones and vitamin DCYP2R1;CYP24A1;GC;STARD5;PPP1R2;CYP27B1;AKR1B15;HSD17B11
Steroid hormone biosynthesisHSD3B1;HSD11B1;HSD17B12B;HSD17B12A;HSD3B4;H2-KE6;UGT2B7;UGT1A7;UGT1AB

PPP1R2 has several biochemical functions, for example, 3-oxo-5-alpha-steroid 4-dehydrogenase activity, oxidoreductase activity, acting on the CH-CH group of donors. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1R2 itself. We selected most functions PPP1R2 had, and list some proteins which have the same functions with PPP1R2. You can find most of the proteins on our site.

Function Related Protein
3-oxo-5-alpha-steroid 4-dehydrogenase activitySRD5A2A;SRD5A2B;PPP1R2;SRD5A1;SRD5A2;SRD5A3
oxidoreductase activity, acting on the CH-CH group of donorsCOX15;SRD5A3;TECR;SRD5A2B;TM7SF2;TECRL2B;DPYDB;LBR;GCDHB

PPP1R2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1R2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1R2.

PPP1CC; GSK3B; PPP1CA; LMTK2; TINF2; MYC; PPP1CB; Ppp1r10; Cep72; PPP1CC

Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).
Yamaoka, K; Kaminuma, O; et al. Protein phosphatase 1 is involved in IL-2-induced IL-5 and IL-13 expression in human T cells. GENES TO CELLS 17:611-618(2012).
  • Q&As
  • Reviews

Q&As (6)

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What is the relationship of PPP1R2 to other proteins? 04/23/2022

It has a complex relationship with other proteins. For example, it interacts with PPP1, regulating its activity. In addition, PPP1R2 also interacts with other proteins and participates in a variety of biological processes.

Is there a treatment strategy for PPP1R2? 01/03/2022

Treatment strategies for PPP1R2 include inhibition of its expression, modulation of its activity, or the use of gene therapy. For example, some studies have shown that the use of small molecule inhibitors against PPP1R2 can inhibit its activity and thus treat some PPP1R2-related diseases. In addition, it is also possible to treat related diseases by regulating the expression level of PPP1R2.

How is the expression level of PPP1R2 related to the disease? 08/15/2021

Studies have shown that the expression level of PPP1R2 is associated with a variety of diseases. For example, in some tumors, the expression level of PPP1R2 is upregulated, which may promote the proliferation and metastasis of tumor cells. In some neurodegenerative diseases, PPP1R2 expression levels may be down-regulated, leading to dysregulation of intracellular phosphorylation balance, which in turn leads to neuronal death.

Why are the PPP1R2 studies limited? 03/24/2021

There are still some limitations in the current research on PPP1R2, such as the lack of in-depth research on its specific mechanism of action and function, and the incomplete understanding of its relationship with diseases. In addition, since PPP1R2 is a multifunctional protein, regulating it may also have some side effects.

What is the role of PPP1R2 in cells? 01/02/2021

PPP1R2 plays an important regulatory role in cells. It binds to PPP1 and regulates the phosphorylation level of intracellular proteins by inhibiting or activating the activity of PPP1. This regulatory effect has important implications for many biological processes such as cell cycle, gene expression, and signal transduction.

What new mechanisms or functions have been discovered in recent studies on PPP1R2? 11/06/2020

Recent studies have found that PPP1R2 is also involved in intracellular signaling processes. These processes have an important impact on cell growth, differentiation and migration, and also provide new ideas for the treatment of some PPP1R2-related diseases.

Customer Reviews (3)

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Reviews
10/21/2022

    Strong anti-pollution ability, safe to use.

    06/23/2020

      PPP1R2 has a wide range of applications and can be applied to various types of experiments.

      04/24/2020

        The quality of the products is stable, which greatly improves the efficiency of our scientific research.

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