ppp2ca
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  • Official Full Name
  • protein phosphatase 2, catalytic subunit, alpha isozyme
  • Background
  • PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at Ser-259.
  • Synonyms
  • PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2Calpha; protein phosphatase 2A catalytic su
Cat.#:PPP2CA-15HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human PPP2CA protein, MYC/DDK-tagged
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Cat.#:PPP2CA-1913HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2CA, His-tagged
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Cat.#:PPP2CA-27617THTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human PPP2CA protein, GST-tagged
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Cat.#:PPP2CA-13249MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP2CA Protein
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Cat.#:PPP2CA-4631RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP2CA Protein
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Cat.#:PPP2CA-1304CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP2CA
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Cat.#:PPP2CA-2607ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP2CA
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Cat.#:PPP2CA-2929HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP2CA 293 Cell Lysate
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Involved Pathway

PPP2CA involved in several pathways and played different roles in them. We selected most pathways PPP2CA participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CA were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
pab1; HBS1L; ETF1B; GSPT1L; SRRM1; MAGOH2; FIP1L1; PAPOLB; PABPC1A; PPP2R5A
Sphingolipid signaling pathway
SMPD1; PLCB1; BDKRB2; FCER1G; SGPL1; ASAH1; FCER1A; PIK3R2; SPTLC3; DEGS1
Oocyte meiosis
CALM1; SMC3; STAG3; RPS6KA3A; PPP1CC; ADCY1B; PPP2R5B; CDC23; PPP1CB; PRKACAB
PIK-Akt signaling pathway
YWHAE; IRS1; IL2RG; YWHAZ; GH2; STK11; PGF; ATF4; Kitl; PRKAA1
AMPK signaling pathway
GYS1; PPP2R5D; ADRa1A; STRADB; CREB3L1; CAMKK1; ELAVL1; G6PC2; CPT1C; PRKAA1
Adrenergic signaling in cardiomyocytes
PPP2R1A; ADCY1A; SLC9A1; CACNG2; PLCB4; ATP1B3B; CALM2A; TPM4A; CALM1; TNNC1B
TGF-beta signaling pathway
BMPR2A; GDF5; IFNG; ID1; TGFBR2; TFDP1A; PPP2R1A; TNF; BAMBIA; ACVR2A
Hippo signaling pathway
LLGL1; PPP1CB; JUB; SMAD7; AFP; SOX2; ACTG1; CCND1; WNT4; SMAD1
Tight junction
MYH13; CLDND; MYH1E; CLDN19; CLDN10; PPP2CA; PRKCB; SRC; PRKCDA; MYL12.1
Dopaminergic synapse
CREB3; MAPK12; GNG12; GNGT1; PRKACA; GNG11; SLC18A1; AKT1; DRD3; GNGT2
Long-term depression
GRID2; PPP1R17; MAPK3; GNAI2; MAPK1; ITPR3; RAF1; PLA2G4F; PPP2R1A; GNAI1
Chagas disease (American trypanosomiasis)
CD3G; TICAM1; PIK3CD; PLCB1; PIK3CG; CALR; PIK3R2; SMAD3; PPP2CA; IRAK1
Hepatitis C
MAPK3; IRF3; IFNAR1; PPP2CA; NFKB1; OAS1B; IKBKG; CLDN20; CLDN7; IFNA6

Protein Function

PPP2CA has several biochemical functions, for example, GABA receptor binding, metal ion binding, phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CA itself. We selected most functions PPP2CA had, and list some proteins which have the same functions with PPP2CA. You can find most of the proteins on our site.
Function
Related Protein
Function GABA receptor binding
Related Protein AKAP5; GABRB1; PLCL1; GABARAPA; GABARAP; GABRG1; GABARAPL2; TRAK1; PLCL2; PPP2CA
Function metal ion binding
Related Protein CYP1C1; ACAP2; ACLY; NT5C2; RARGB; ISG20; CYP2Y3; AGO2; ATP2B4; ZNF469
Function phosphoprotein phosphatase activity
Related Protein DUSP22A; PPM1AB; PPP1R3B; CDC14AA; PPP4CB; SSH2; PPP3CCB; CTDSPL2A; PPM1LA; PTPRU
Function protein C-terminus binding
Related Protein STIP1; SNX17; TCF4; TOP2A; NCL; MAP2K1; TRIM3; TAF13; PEX16; CDK7
Function protein binding
Related Protein CBX4; SMAD3A; SPEF1; ICAM5; STK4; RGL2; TAF10; ZNF576; KIF9; CDKN3

Interacting Protein

PPP2CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CA.
PPP2R1A; IGBP1