PPP2CA Protein, protein phosphatase 2, catalytic subunit, alpha isozyme

PPP2CA

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PPP2CA

Official Full Name protein phosphatase 2, catalytic subunit, alpha isozyme
Background PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at Ser-259.
Synonyms PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2Calpha; protein phosphatase 2A catalytic su
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP2CA-33H Recombinant Human PPP2CA Protein, His-tagged Insect Cell His
    Human PPP2CA-15H Recombinant Human PPP2CA protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PPP2CA-1913H Recombinant Human PPP2CA, His-tagged E.coli His
    Human PPP2CA-27617TH Recombinant Human PPP2CA protein, GST-tagged Wheat Germ GST
    Human PPP2CA-2929HCL Recombinant Human PPP2CA 293 Cell Lysate HEK293 N/A
    Mouse PPP2CA-13249M Recombinant Mouse PPP2CA Protein Mammalian Cell His
    Rat PPP2CA-4631R Recombinant Rat PPP2CA Protein Mammalian Cell His
    Chicken PPP2CA-1304C Recombinant Chicken PPP2CA Mammalian Cell His
    Zebrafish PPP2CA-2607Z Recombinant Zebrafish PPP2CA Mammalian Cell His

    PPP2CA involved in several pathways and played different roles in them. We selected most pathways PPP2CA participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway PABPC1; SSU72; SRRM1; PCF11; MAGOHB; PPP2R2CA; UPF3B; PPP2R5D; CSTF2T; PPP2R1B
    Sphingolipid signaling pathway TP53; LASS4; FCER1A; BID; PIK3CA; PPP2R2C; HRAS; MAPK9; TRAF2; PPP2R5D
    Oocyte meiosis REC8; INS1; IGF1RB; PPP1R2P9; PLCZ1; PPP3CCA; YWHAE1; PGR; PLK1; CPEB1B
    PIK-Akt signaling pathway RPTOR; SYK; PKN1; IFNA1; IL3; MTCP1; Il6ra; TNC; IFNA10; PDGFB
    AMPK signaling pathway PPP2R3A; ADIPOR2; HMGCR; LEPR; CCNA1; G6PC; TBC1D1; LIPE; CREB3L1; RPS6KB2
    Adrenergic signaling in cardiomyocytes ACTC1B; CACNB3A; ADCY1A; PIK3CG; PPP2R5B; CACNB3; TPM4; CACNG7; TNNT2A; ATP1B1A
    TGF-beta signaling pathway RBL1; BMPR2A; BMPR1BA; TGFB1A; PPP2R1B; RHOAD; RHOAB; INHBAB; SP1; EP300
    Hippo signaling pathway ACTG1; TCF7L2; GDF5; BMP7; YWHAZ; FZD2; PPP2R2A; PPP2R2B; BBC3; PPP2CA
    Tight junction EXOC4; VMHCL; CLDN15; CLDNC; ACTB2; MYH7; NRAS; MYH15; CLDN15LB; EPB41L3B
    Dopaminergic synapse GNGT2; GRIN2B; SLC18A1; CREB3L4; PPP2R2C; GNAS; PPP2R5E; KCNJ3; PPP3CB; DRD2
    Long-term depression PRKCB; PLA2G4F; NOS1; GNA11; GRM1; RYR1; ITPR3; PPP2CB; ARAF; PLCB4
    Chagas disease (American trypanosomiasis) LOC100033925; CD3G; MYD88; IKBKB; GNAL; CCL3; CD3E; GNAI2; IFNGR1; PIK3R5
    Hepatitis C Ifna11; CLDN22; IFNA16; CLDN6; NR1H3; RAF1; EIF2AK4; IFNAR2; MAPK1; PIK3CB

    PPP2CA has several biochemical functions, for example, GABA receptor binding, metal ion binding, phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CA itself. We selected most functions PPP2CA had, and list some proteins which have the same functions with PPP2CA. You can find most of the proteins on our site.

    Function Related Protein
    GABA receptor binding PPP2CA; PLCL2; MAF1; GABRA5; GABRB1; JAKMIP1; PLCL1; ARFGEF2; TRAK1; GABARAPL2
    metal ion binding CCDC71L; RIMS1; QTRT1; ZC3H3; ZFP580; ZNF596; ZNF565; C6AST1; TMEM129; HMGCL
    phosphoprotein phosphatase activity PPP1CC; PPP3CCA; MTM1; PTPN20; DUSP16; CTDSPL2B; DUSP10; PPM1AB; PTPN23A; PTPN11A
    protein C-terminus binding KCNK3; BCAM; ECM1; PDZD3; ZBTB16; MAPRE1; ERBB2; TOP2B; PIAS4; PIAS3
    protein binding SPATA22; TMEM139; PKD1L3; WDR77; LDB1; SRRT; CDK17; EEF1E1; CD36; TSSK3

    PPP2CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CA.

    PPP2R1A; IGBP1

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