ppp2cb
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  • Official Full Name
  • protein phosphatase 2, catalytic subunit, beta isozyme
  • Background
  • This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. This gene encodes a beta isoform of the catalytic subunit.
  • Synonyms
  • PPP2CB; protein phosphatase 2, catalytic subunit, beta isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, beta isoform; serine/threonine-protein phosphatase 2A catalytic subunit beta isoform; PP2Abeta; protein phosphatase 2A catalytic subunit; beta isoform; PP2A beta; PP2A-beta; PP2AB_HUMAN; PP2CB; Protein phosphatase 2 catalytic subunit beta isozyme; Protein phosphatase 2, catalytic subunit, beta isoform; Protein phosphatase 2A catalytic subunit beta isoform; Protein phosphatase type 2A catalytic subunit; Serine/threonine protein phosphatase 2A catalytic subunit beta; OTTHUMP00000225455; protein phosphatase 2A catalytic subunit, beta isoform; serine/threonine protein phosphatase 2A, catalytic subunit, beta isoform
Cat.#:PPP2CB-1178HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2CB Protein (1-309 aa), GST-tagged
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Cat.#:PPP2CB-27931THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PPP2CB
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Cat.#:PPP2CB-650HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2CB Protein, His-tagged
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Cat.#:PPP2CB-13250MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP2CB Protein
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Cat.#:PPP2CB-4632RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PPP2CB Protein
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Cat.#:PPP2CB-3570RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PPP2CB Protein, His-tagged
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Cat.#:PPP2CB-6681CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP2CB
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Cat.#:PPP2CB-12481ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP2CB
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Cat.#:PPP2CB-2927HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PPP2CB 293 Cell Lysate
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Cat.#:PPP2CB-2928HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PPP2CB 293 Cell Lysate
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Involved Pathway

PPP2CB involved in several pathways and played different roles in them. We selected most pathways PPP2CB participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
mRNA surveillance pathway
PPP2R1B; CPSF1; PPP1CBL; PAPOLB; FIP1L1; ETF1; WIBG; NCBP2; PPP2R2CA; CPSF7
Sphingolipid signaling pathway
SPTLC1; S1PR4; SPHK2; OPRD1; ASAH1; SMPD2; GNAQ; BCL2; PPP2R1A; RELA
Oocyte meiosis
ANAPC2; PPP2R5EB; MAD2L1; Ar; YWHAE1; CCNB1; IGF1RB; RPS6KAL; ANAPC1; MOS
PIK-Akt signaling pathway
ITGA3; GHR; GNG7; ITGA8; CASP9; PRKAA1; FGFR3; PKN1; LAMB4; ITGA2B
AMPK signaling pathway
INS2; PPP2R2A; G6PC; PDPK1; PPP2R5C; ELAVL1; PIK3CA; PIK3R2; PRKAB1; PFKFB4
Adrenergic signaling in cardiomyocytes
GNA11A; GNAI3; PRKACAB; CACNB2; AKT1; PPP2R5A; ATP1B3A; PPP2R3C; ATP1A3; MAPK3
TGF-beta signaling pathway
BMP7A; TGFBR2; ID1; BMP7; CUL1A; ROCK1; ACVR1; SKP1; LEFTY2; MAPK3
Hippo signaling pathway
CTGF; WNT3; BMP6; PPP2R1B; CRB1; FZD2; TGFB2; WNT1; SOX2; YWHAZ
Tight junction
SMYHC1; PRKCZ; ASH1L; MYLPF; MLLT4; TJP2A; PRKCQ; LLGL1; CLDN16; OCLNB
Dopaminergic synapse
MAPK11; GNG2; COMT; KCNJ9; PPP2R5B; PRKACA; GNG7; KCNJ6; FOS; CAMK2B
Long-term depression
PPP2CB; PLCB3; GNA12; GUCY1B3; ARAF; PRKCG; PLA2G4A; PRKG1; PLCB2; GRM1
Chagas disease (American trypanosomiasis)
CD3D; TICAM1; C1QA; MAPK12; Il2; NFKB1; PLCB3; SMAD3; CXCL8; MAPK13
Hepatitis C
CXCL8; EIF3E; IFNA16; IFNA7; IFNAR1; SOS1; IRF1; EIF2AK2; NRAS; BRAF

Protein Function

PPP2CB has several biochemical functions, for example, metal ion binding, protein C-terminus binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CB itself. We selected most functions PPP2CB had, and list some proteins which have the same functions with PPP2CB. You can find most of the proteins on our site.
Function
Related Protein
Function metal ion binding
Related Protein WBP7; PM20D1.1; BTR18; FOXP1B; LNPA; AMPD3; SMG1; FYN; NR4A2B; ZNF398
Function protein C-terminus binding
Related Protein GRIP1; MRE11A; PABPC1; TNNI3K; XRCC6; FOXN3; TAE1; EFHC1; CDK7; SNF8
Function protein binding
Related Protein ARNTL2; TMEM43; AHCYL2; SH2D4A; PAWR; BBS7; PRKD1; BACE1; ALS2CR11; NXF3
Function contributes_to protein serine/threonine phosphatase activity
Related Protein CYCS; PPP2CB

Interacting Protein

PPP2CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CB.
PPP2R1A; IGBP1; AXIN2; TCP1; CCT6A