ppp2r4
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  • Official Full Name
  • PPP2R4 protein phosphatase 2A activator, regulatory subunit 4
  • Background
  • Type 2 protein serine/threonine phosphatase (PP2A) is a trimer composed of a catalytic C subunit and two regulatory (A and B) subunits; many isoforms for the A and B subunits have been found. PP2A has a high specific activity against the alpha subunit of phosphorylase kinase and is insensitive to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. It is also thought to be the principal downmodulator of serine/threonine kinase cascades. PP2B requires Ca2+/calmodulin for activity, and is an activator of NFAT transcription factors. PP2C requires Mg2+, but is insensitive to okadaic acid, microcystin LR, or the calmodulin inhibitor trifluoperazine.
  • Synonyms
  • PPP2R4; protein phosphatase 2A activator, regulatory subunit 4; protein phosphatase 2A, regulatory subunit B (PR 53); serine/threonine-protein phosphatase 2A activator; phosphotyrosyl phosphatase activator; PP2A phosphatase activator; PR53; PTPA; PP2A subunit B isoform PR53; serine/threonine-protein phosphatase 2A regulatory subunit B; PP2A; MGC2184
Cat.#:PPP2R4-27572THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2R4, His-tagged
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Cat.#:PPP2R4-589HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PPP2R4
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Cat.#:PPP2R4-13260MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PPP2R4 Protein
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Cat.#:PPP2R4-3022CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PPP2R4
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Cat.#:PPP2R4-878ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PPP2R4
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Cat.#:PPP2R4-2919HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PPP2R4 293 Cell Lysate
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Involved Pathway

PPP2R4 involved in several pathways and played different roles in them. We selected most pathways PPP2R4 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Insulin resistance
SLC2A1; PRKAA1; NOS3; PRKCB; PPP1R3CB; TRIB3; G6PCA.2; GFPT1; PIK3CG; CREB3L3L

Protein Function

PPP2R4 has several biochemical functions, for example, ATP binding, contributes_to ATPase activity, peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R4 itself. We selected most functions PPP2R4 had, and list some proteins which have the same functions with PPP2R4. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ADCY9; CCT7; FYNB; PKMYT1; MELK; SIK2A; SGK2B; SMC1B; ALK; PAK2
Function contributes_to ATPase activity
Related Protein ATP5B; ATP5J; ATP5E; ABCA7; ATP5J2; MSH2; ATP5C1; PPP2R4; ABCG8; SFRP5
Function peptidyl-prolyl cis-trans isomerase activity
Related Protein PPIC; FKBP11; FKBP8; PIN4; FKBP3; FKBP7; TTC9C; PPIL1; FKBP14; PPIAA
Function protein binding
Related Protein RP9; LONP1; CPEB4; APOH; DHRS2; PPP2R5E; BACE1; DIAP1; RNF182; PARD3
Function protein heterodimerization activity
Related Protein TCF3A; MAFG; HIST1H47; UGT1A1; TBX15; HSPD1; DRD1; HIST4H4; TYRP1; PDGFA
Function protein homodimerization activity
Related Protein PLEK; BCL2A1A; TWIST1; FZD9; SOD1; FLT3LG; CD4; ANG; TOX3; IKZF2
Function protein phosphatase 2A binding
Related Protein MAPT; BCL2; ENSAA; HMGCR; TP53; SPHK1; ARPP19; EIF4EBP1; PPME1; MASTL
Function protein phosphatase type 2A regulator activity
Related Protein PPP2R5E; pab1; PPP2R2BB; PPP2R5B; PPME1; SET; PPP2R3A; PPP2R5EA; PPP2R2B; PPP2R4
Function protein tyrosine phosphatase activator activity
Related Protein PPP2R4; IGFBP3
Function receptor binding
Related Protein CNPY4; ADAM10; MAG; PCSK1N; RAB8B; RSPO2; ITGA1; SRPX2; CADM3; CADM4

Interacting Protein

PPP2R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R4.
AMOT; BRINP1; Kiaa1109; TCP1; CCT6A; CCT5; CCT3; CCT8; CCT4; PPP2CA; CCT2; CCT7; AKT1