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PARK2

  • Official Full Name

    parkinson protein 2, E3 ubiquitin protein ligase (parkin)

  • Overview

    The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
  • Synonyms

    PARK2; PDJ; PRKN; AR-JP; LPRS2; parkin; parkinson protein 2, E3 ubiquitin protein ligase (parkin); E3 ubiquitin-protein ligase parkin; parkin 2; OTTHUMP00000017562; OTTHUMP00000017563; OTTHUMP00000017564; OTTHUMP00000017565; OTTHUMP00000017566; OTTHUMP00000017567; E3 ubiquitin ligase; parkinson disease protein 2; parkinson juvenile disease protein 2; Parkinson disease (autosomal recessive, juvenile) 2, parkin; EC 6.3.2.-;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Rat
  • Zebrafish
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Sf9 Insect Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PARK2-332H Active Recombinant Human PARK2 protein Insect Cell N/A
Human PARK2-30784TH Recombinant Human PARK2 Wheat Germ N/A 387 amino acids
Human PARK2-1529H Recombinant Human PARK2, His-tagged E.coli His C-term-307aa
Human PARK2-5021H Recombinant Human PARK2, His-tagged E.coli His
Human PARK2-421H Recombinant Human PARK2 protein, His-tagged, Active Insect Cell His
Human PARK2-30785TH Recombinant Human PARK2 Wheat Germ N/A 100 amino acids
Human PARK2-420H Recombinant Human parkin RBR E3 ubiquitin protein ligase, His-tagged E.coli His
Human PARK2-231H Recombinant Human PARK2, GST-tagged Sf9 Insect Cell GST
Human PARK2-422H Recombinant Human PARK2 protein E.coli N/A
Human PARK2-3433HCL Recombinant Human PARK2 293 Cell Lysate HEK293 N/A
Human PARK2-11H Recombinant Human PARK2 protein, His-tagged HEK293 His
Human PARK2-356HF Recombinant Full Length Human PARK2 Protein In Vitro Cell Free System 387 amino acids
Mouse PARK2-12362M Recombinant Mouse PARK2 Protein Mammalian Cell His
Mouse PARK2-6497M Recombinant Mouse PARK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse PARK2-6497M-B Recombinant Mouse PARK2 Protein Pre-coupled Magnetic Beads HEK293
Rat PARK2-4273R Recombinant Rat PARK2 Protein Mammalian Cell His
Rat PARK2-3935R Recombinant Rat PARK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PARK2-3935R-B Recombinant Rat PARK2 Protein Pre-coupled Magnetic Beads HEK293
Rat Park2-4799R Recombinant Rat Park2 protein, His&Myc-tagged E.coli His&Myc 1-465aa
Cynomolgus Monkey PARK2-772C Recombinant Cynomolgus PARK2 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey PARK2-516C Recombinant Cynomolgus Monkey PARK2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey PARK2-516C-B Recombinant Cynomolgus Monkey PARK2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish PARK2-2405Z Recombinant Zebrafish PARK2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein

PARK2 involved in several pathways and played different roles in them. We selected most pathways PARK2 participated on our site, such as Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum, Parkinsons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with PARK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Ubiquitin mediated proteolysisUBE2J1;ERCC8;CUL3;UBA2;UBR5;FBXO4;PARK2;UBE2L3B;SIAH1A
Protein processing in endoplasmic reticulumUBE2D2L;MAPK9;UBE2D1A;ERO1LB;CAPN2A;SELS;SAR1A;GANAB;RAD23AB
Parkinsons diseaseNDUFB5;NDUFV2;SDHD;NDUFB7;UCHL1;NDUFA6;NDUFS4;COX5A;SLC18A1

PARK2 has several biochemical functions, for example, F-box domain binding, G-protein coupled receptor binding, Hsp70 protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PARK2 itself. We selected most functions PARK2 had, and list some proteins which have the same functions with PARK2. You can find most of the proteins on our site.

Function Related Protein
F-box domain binding
G-protein coupled receptor bindingUSP33;UCN3;HAND2;HSPA8;RSPO3;ADORA1;PYY;RSPO1;GNA13B
Hsp70 protein bindingPPEF2;DNAJA1;L7RN6;METTL21A;FAM119A;PARK2;CDKN1B;DNAJC2;RNF207
PDZ domain bindingGNG12;CFTR;BAIAP2;ARHGEF16;SLC9A3R1;ERC1;FZD8;PTENB;NLGN1
SH3 domain bindingCD3E;PTTG2;OSTF1;SH3BP5LA;KHDRBS1;ABI2;DPYSL3;FMNL3;ITM2B
actin bindingWASLB;FMN1;SPNA1;SYNE2;CORO7;DIAP3;CNN1;CCDC88A;CFL2
beta-catenin bindingRORA;PTPRU;SOX17;TRPC4;DACT1;AXIN1;CTNNBIP1;DVL3;C
chaperone bindingAlb;UBL4;SOD1;ERP29;TBCE;FGB;DNAJB6;HES1;BAK1
cullin family protein bindingDCUN1D2A;PARK2;DCUN1D5;TCHP;ANAPC11;DCUN1D2;RBX1;DCUN1D4;DCUN1D3
enzyme bindingRAC1;JUN;HMGA1-RS1;DAXX;ERN1;CYP1A1;THRB;PEX5;NKX2-1
heat shock protein bindingHSPA8;LIMK1;DLST;GM5506;APAF1;DMPK;KCNJ11;SSUH2RS1;IRAK1
histone deacetylase bindingNCOR2;SIX3;CRY1;SOD3;BRMS1;NKX2-5;BCOR;KAT2A;ANKRA2
identical protein bindingREG3B;CLDN6;SEPHS1;ATXN3;MTSS1;TP73;CDC42BPA;EGFR;ITGB3
kinase bindingHAP1;SGOL1;PTPN22;NTRK1;ATF5;SP100;ABI2;TAX1BP1;TRIP6
ligase activityZNRF2;UNKL;RNF182;UBE2KA;RNF5;RNF115;TRIM56;SHPRH;MARCH8
phospholipase bindingCALM1;LMNB1;SNCA;PTPN11;CALM2;CALM3;SELE;CALM;APOC2
protein bindingDGKQ;YIPF2;FMR1;DDX17;PPP2R5A;CLCF1;NEURL1B;RPF1;AGL
protein kinase bindingPPP1R15A;GOLGA2;MAP3K13;DVL1;SLC12A7;KIF20A;TCTN2;CACNB2;AXIN1
tubulin bindingCENPJ;NCALD;LRRK2;CDK5RAP2;MTAP4;DAG1;RPS3;KIF14;MAP1S
ubiquitin bindingPER2;SQSTM1;UCHL1;UBE2NB;TSG101;BRAP;VPS36;UBAP1;FAN1
ubiquitin conjugating enzyme bindingRNF144AA;ARIH2;DCUN1D2B;RNF217;GRIK2;RNF19A;SIAH2;DCUN1D2A;DCUN1D4
ubiquitin protein ligase activityCDC42;HECW2;HECTD2;RNF19B;FANCL;HERC3;NEURL3;RNF152;CBLC
ubiquitin protein ligase activity involved in ERAD pathwayRNF185;PARK2;RNF5;TMEM129;STUB1;AMFR;TRIM25;SYVN1
ubiquitin protein ligase bindingANAPC2;UBE2W;CCT2;SMAD6;PER3;HIF1A;MC4R;USP25;SQSTM1
ubiquitin-protein transferase activityMUL1A;TRAF2;BIRC8;FBXL6;TRIP12;LTN1;UBE2E2;FBXO3;SIAH1
ubiquitin-specific protease bindingSELS;DERL1;RAD23A;AMFR;MARCH6;SYVN1;VPS24;BAG6;PARK2
zinc ion bindingDTX4;YAF2;APOBEC3H;YY1;BRF1;ADAMTS16;ADAMTS8;NR6A1;USP3

PARK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PARK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PARK2.

PINK1; RANBP2

  • Q&As
  • Reviews

Q&As (5)

Ask a question
Are there any other neurological disorders associated with PARK2 mutations? 05/13/2022

Besides Parkinson's disease, PARK2 mutations have been linked to other neurodegenerative disorders, expanding the clinical implications of studying this protein.

Can PARK2 protein be a target for drug development in Parkinson's disease? 02/27/2022

Yes, drug development efforts are underway to modulate PARK2 activity and enhance its neuroprotective functions as a potential therapeutic approach for Parkinson's disease.

In what ways does PARK2 protein research contribute to our understanding of mitochondrial dynamics in neurodegenerative diseases? 05/29/2020

PARK2 research provides crucial insights into the role of mitochondrial dynamics in neurodegenerative diseases, helping unravel the mechanisms underlying these disorders and paving the way for targeted therapies.

How can genetic testing for PARK2 mutations aid in personalized medicine for Parkinson's patients? 02/21/2020

Genetic testing can help identify individuals with PARK2 mutations, allowing for personalized treatment strategies tailored to their specific genetic profile.

How is PARK2 protein linked to the regulation of inflammation in the brain? 12/31/2019

PARK2 is implicated in controlling inflammation in the brain, and its dysfunction may contribute to neuroinflammatory processes observed in Parkinson's disease.

Customer Reviews (3)

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Reviews
04/18/2020

    Their expertise and commitment to customer satisfaction make them a trusted partner in achieving research goals.

    12/02/2016

      Their knowledgeable team is readily available to address any questions or concerns, guaranteeing a smooth experimental process.

      02/25/2016

        the manufacturer of PARK2 protein provides excellent technical support, ensuring prompt assistance and guidance.

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