Recombinant Human PRKN Protein (Ile229-Val465), N-His tagged

• Cat.No.: PRKN-5441H
• Product Overview: Recombinant human PRKN (Ile229-Val465) fused with the N-His tag was expressed in E. coli.

Specification

• Description: The precise function of this gene is unknown; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.
• Source: E. coli
• Species: Human
• Tag: N-His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 29.01 kDa
• Protein Length: Ile229-Val465
• Purity: > 90 % as determined by SDS-PAGE
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: 0.01M PBS, pH 7.4, 0.02 % NLS
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: PRKN parkin RBR E3 ubiquitin protein ligase [ Homo sapiens (human) ]
• Official Symbol: PRKN
• Synonyms: PRKN; parkin RBR E3 ubiquitin protein ligase; PDJ; AR-JP; LPRS2; PARK2; E3 ubiquitin-protein ligase parkin; Parkinson disease (autosomal recessive, juvenile) 2, parkin; parkinson juvenile disease protein 2; parkinson protein 2 E3 ubiquitin protein ligase; parkinson protein 2, E3 ubiquitin protein ligase (parkin); EC 2.3.2.31
• Gene ID: 5071
• mRNA Refseq: NM_004562
• Protein Refseq: NP_004553
• MIM: 602544
• UniProt ID: O60260