prph
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  • Official Full Name
  • peripherin
  • Background
  • This gene encodes a cytoskeletal protein found in neurons of the peripheral nervous system. The encoded protein is a type III intermediate filament protein with homology to other cytoskeletal proteins such as desmin, and is a different protein that the peripherin found in photoreceptors. Mutations in this gene have been associated with susceptibility to amyotrophic lateral sclerosis.
  • Synonyms
  • PRPH; peripherin; NEF4; PRPH1; neurofilament 4 (57kD)
Cat.#:PRPH-177HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Peripherin
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Cat.#:PRPH-1980HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PRPH, His-tagged
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Cat.#:PRPH-30642THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRPH
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Cat.#:PRPH-30643THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PRPH
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Cat.#:PRPH-8682ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PRPH
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Cat.#:PRPH-2822HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PRPH 293 Cell Lysate
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Involved Pathway

PRPH involved in several pathways and played different roles in them. We selected most pathways PRPH participated on our site, such as Amyotrophic lateral sclerosis (ALS), which may be useful for your reference. Also, other proteins which involved in the same pathway with PRPH were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amyotrophic lateral sclerosis (ALS)
CAT; PPP3CB; TRP53; CYCS; APAF1; CASP9; NOS1; PRPH; SLC1A2; BID

Protein Function

PRPH has several biochemical functions, for example, protein heterodimerization activity, structural molecule activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PRPH itself. We selected most functions PRPH had, and list some proteins which have the same functions with PRPH. You can find most of the proteins on our site.
Function
Related Protein
Function protein heterodimerization activity
Related Protein TPD52; CASP8; TBX18; TYRO3; HOMER2; RALGAPA2; HMG20B; ABCG1; ALG2; SMC1A
Function structural molecule activity
Related Protein SPRR2H; CAV1; SEPT4; KRT97; CLDN10B; CYLC1; EPB41L2; CLTA; CTNNA1; FGB

Interacting Protein

PRPH has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRPH here. Most of them are supplied by our site. Hope this information will be useful for your research of PRPH.
VIM; KRT15; GABARAPL2; ESR2; GABARAPL1

PRPH Related Articles

McRoberts, JA; Ennes, HS; et al. SELECTIVE KNOCKDOWN OF NMDA RECEPTORS IN PRIMARY AFFERENT NEURONS DECREASES PAIN DURING PHASE 2 OF THE FORMALIN TEST. NEUROSCIENCE 172:474-482(2011).
Strom, A; Sonier, B; et al. Peripherin-Reactive Antibodies in Mouse, Rabbit, and Human Blood. JOURNAL OF PROTEOME RESEARCH 9:1203-1208(2010).
Leung, CL; He, CZ; et al. A pathogenic peripherin gene mutation in a patient with amyotrophic lateral sclerosis. BRAIN PATHOLOGY 14:290-296(2004).
FERRARI, N; DESMARAIS, D; et al. TRANSCRIPTIONAL ACTIVATION OF THE NEURONAL PERIPHERIN-ENCODING GENE DEPENDS ON A G+C-RICH ELEMENT THAT BINDS SP1 IN-VITRO AND IN-VIVO. GENE 159:159-165(1995).