psmf1
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  • Official Full Name
  • proteasome (prosome, macropain) inhibitor subunit 1 (PI31)
  • Background
  • The 26S proteasome is a multicatalytic proteinase complex with a highly ordered structure composed of 2 complexes, a 20S core and a 19S regulator. The 20S core is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. The 19S regulator is composed of a base, which contains 6 ATPase subunits and 2 non-ATPase subunits, and a lid, which contains up to 10 non-ATPase subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a protein that inhibits the activation of the proteasome by the 11S and 19S regulators. Alternative transcript variants have been identified for this gene.
  • Synonyms
  • PSMF1; proteasome (prosome, macropain) inhibitor subunit 1 (PI31); proteasome inhibitor PI31 subunit; PI31; proteasome inhibitor hP131 subunit; hPI31
Cat.#:PSMF1-1567HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Proteasome (prosome, macropain) Inhibitor Subunit 1 (PI31), His-tagged
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Cat.#:PSMF1-2036HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMF1, GST-tagged
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Cat.#:PSMF1-31210THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PSMF1, His-tagged
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Cat.#:PSMF1-4790RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PSMF1 Protein
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Cat.#:PSMF1-3223CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PSMF1
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Cat.#:PSMF1-668ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish PSMF1
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Cat.#:PSMF1-2737HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMF1 293 Cell Lysate
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Cat.#:PSMF1-2738HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PSMF1 293 Cell Lysate
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Involved Pathway

PSMF1 involved in several pathways and played different roles in them. We selected most pathways PSMF1 participated on our site, such as Proteasome, which may be useful for your reference. Also, other proteins which involved in the same pathway with PSMF1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Proteasome
PSMD4; PSME2; PSMB9; PSMB11; PSMB5; PSMD4B; PSMB8; PSMD2; PSMD11A; PSMB9B

Protein Function

PSMF1 has several biochemical functions, for example, endopeptidase inhibitor activity, proteasome binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PSMF1 itself. We selected most functions PSMF1 had, and list some proteins which have the same functions with PSMF1. You can find most of the proteins on our site.
Function
Related Protein
Function endopeptidase inhibitor activity
Related Protein C4A; PROS1; C3A.3; USP14; Serpina1c; SPINK2; CST14B.1; C3A.6; MUG2; SERPINA1D
Function proteasome binding
Related Protein ADRM1; DNAJB2; USP14; USP13; ID1; BAG6; UBD; PSMF1; PSMD14; UCHL5
Function protein binding
Related Protein FYTTD1; MINK1; HOXA5; NUDT2; MED21; SOCS2; NFS1; UBE2B; GORASP1; NCOA3

Interacting Protein

PSMF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PSMF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PSMF1.
FBXO7; CD2BP2; RBFOX1; RBFOX2; LDOC1; tax; BEND7; PAK7; PSMA7; KHDRBS3

PSMF1 Related Articles

Li, XH; Thompson, D; et al. Molecular and Cellular Roles of PI31 (PSMF1) Protein in Regulation of Proteasome Function. JOURNAL OF BIOLOGICAL CHEMISTRY 289:17392-17405(2014).
Hatanaka, A; Chen, B; et al. Fub1p, a novel protein isolated by boundary screening, binds the proteasome complex. GENES & GENETIC SYSTEMS 86:305-314(2011).