ptger4
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  • Official Full Name
  • prostaglandin E receptor 4 (subtype EP4)
  • Background
  • The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PTGER4; prostaglandin E receptor 4 (subtype EP4); EP4; EP4R; prostaglandin E2 receptor EP4 subtype; prostanoid EP4 receptor; PGE receptor EP4 subtype; PGE receptor, EP4 subtype; PGE2 receptor EP4 subtype;
Cat.#:PTGER4-4809RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGER4 Protein
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Cat.#:PTGER4-3690RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey PTGER4 Protein, His-tagged
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Cat.#:PTGER4-3654CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGER4
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Cat.#:PTGER4-2716HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTGER4 293 Cell Lysate
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Cat.#:Kit-1489Tag:N/A
Source (Host):Species:
Product namePTGER4 HEK 293 β-Arrestin GPCR Assay Kit
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Cat.#:Kit-0940Tag:N/A
Source (Host):Species:
Product nameCYP2D6 Blue Screening Kit
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Involved Pathway

PTGER4 involved in several pathways and played different roles in them. We selected most pathways PTGER4 participated on our site, such as Neuroactive ligand-receptor interaction, Inflammatory mediator regulation of TRP channels, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGER4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Neuroactive ligand-receptor interaction
CHRNA1; HTR4; RXFP4; TACR3L; MAS1; TBXA2R; GABRA4; TAAR14B; NPY5R; TAAR14G
Inflammatory mediator regulation of TRP channels
MAP2K3; CYP2C55; MAPK9; HTR2C; CAMK2A; PIK3CA; NGF; MAPK8; HTR2B; MAPK12
Renin secretion
PPP3CB; PLCB2; PDE1C; CLCA1; CALM3; CLCA5; PDE1A; GNAI2; CLCA2; PDE1B
Pathways in cancer
CKS2; LPAR3; GNG11; PIK3R1; MECOM; FADD; SMO; FGFR1; GNGT2; Fzd4

Protein Function

PTGER4 has several biochemical functions, for example, prostaglandin E receptor activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGER4 itself. We selected most functions PTGER4 had, and list some proteins which have the same functions with PTGER4. You can find most of the proteins on our site.
Function
Related Protein
Function prostaglandin E receptor activity
Related Protein PTGER4; PTGER4A; PTGER1; PTGER1C; PTGER2A; PTGER1A; PTGER2B; HPGD; PTGER2; PTGER4B
Function protein binding
Related Protein SPATA22; HDAC1; FANCA; LAPTM4B; USP47; PRKRIR; CSNK2A1; MPP5; SILV; ZBTB33