ptges2
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  • Official Full Name
  • prostaglandin E synthase 2
  • Background
  • The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
  • Synonyms
  • PTGES2; prostaglandin E synthase 2; C9orf15, chromosome 9 open reading frame 15; FLJ14038; C9orf15; Gamma interferon activated transcriptional element binding factor 1; GATE binding factor 1; GBF1; Membrane associated prostaglandin E synthase 2; MGC11289; Microsomal prostaglandin E synthase 2; mPGES 2; mPGES-2; PGES2; PGES2_HUMAN; Prostaglandin E synthase 2 truncated form; PTGES 2; OTTHUMP00000022231; OTTHUMP00000022232; OTTHUMP00000215363; GATE-binding factor 1; microsomal prostaglandin E synthase-2; membrane-associated prostaglandin E synthase 2; gamma-interferon-activated
Cat.#:PTGES2-993HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Prostaglandin E Synthase 2, His-tagged
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Cat.#:PTGES2-2045HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES2, GST-tagged
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Cat.#:PTGES2-30326THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES2, His-tagged
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Cat.#:PTGES2-5623HTag:His|T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGES2 protein, His & T7-tagged
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Cat.#:PTGES2-13641MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTGES2 Protein
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Cat.#:Ptges2-5624MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptges2 protein, His-tagged
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Cat.#:PTGES2-828CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus PTGES2 Protein, His-tagged
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Cat.#:PTGES2-2713HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTGES2 293 Cell Lysate
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Cat.#:PTGES2-2714HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTGES2 293 Cell Lysate
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Involved Pathway

PTGES2 involved in several pathways and played different roles in them. We selected most pathways PTGES2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGES2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
GPX6; CYP4F22; DPEP2; CYP2E1; AKR1C3; HPGDS; CYP1B1; CYP2AD2; PTGIS; ALOX12
Metabolic pathways
PRPS1; CKMT2B; FAXDC2; Acsm2a; SEPHS1; ALDOB; CTPS2; FBP2; AGXT; NDUFAB1A

Protein Function

PTGES2 has several biochemical functions, for example, DNA binding, electron carrier activity, glutathione binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGES2 itself. We selected most functions PTGES2 had, and list some proteins which have the same functions with PTGES2. You can find most of the proteins on our site.
Function
Related Protein
Function DNA binding
Related Protein ZFP821; TLX3B; MKXA; ANKRD1; KCNH7; ZNF224; HOXC11A; ZFP629; KIF22; MYC
Function electron carrier activity
Related Protein ACAD9; NOX4; COX7A2A; AOX3L1; AKR1A1; AIFM1; XDH; COX7A1; NQO2; IDH3B
Function glutathione binding
Related Protein PTGES; PTGESL; GSS; LANCL1; PTGES2; GSTM1; GSTM4; GSTP2; LTC4S; GSTM2
Function heme binding
Related Protein CYP2X8; HEBP1; CYP1D1; NOX4; CYP4F14; BA1; CYB5R4; CYP2E1; CYP46A1.3; SDHDB
Function lyase activity
Related Protein ALDOCA; HMGB1; CBSB; AGXT2L2; POLB; GLDC; Car12; TYW1B; GAD1B; CTHL
Function prostaglandin-E synthase activity
Related Protein PTGES; PTGESL; PTGES2; PTGES3
Function protein binding
Related Protein IL7; NSMCE2; RTP2; KXD1; MAU2; MALT1; BCAR3; RBPMS2B; ROBO2; BCOR
Function protein disulfide oxidoreductase activity
Related Protein GLRX5; TXNRD1; GLRX2; ERO1LB; TXNRD3; CCS; ERO1L; GRX2; PTGESL; GRXCR1

Interacting Protein

PTGES2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGES2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGES2.
C1orf189; HTT; EXOSC10; uvrB; MYC; 1C; H2AFX