ptgs2
Share
  • Official Full Name
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Background
  • Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2.
  • Synonyms
  • Ptgs2; prostaglandin-endoperoxide synthase 2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase, Tis10
Cat.#:PTGS2-26360THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PTGS2, His-tagged
+Inquiry
Cat.#:PTGS2-30HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, His-tagged
+Inquiry
Cat.#:PTGS2-32HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, FLAG/His-tagged
+Inquiry
Cat.#:PTGS2-523HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2
+Inquiry
Cat.#:PTGS2-677HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
+Inquiry
Cat.#:PTGS2-678HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
+Inquiry
Cat.#:PTGS2-857HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2, His tagged
+Inquiry
Cat.#:PTGS2-13651MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTGS2 Protein
+Inquiry
Cat.#:Ptgs2-679MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptgs2 protein, His-tagged
+Inquiry
Cat.#:PTGS2-4817RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGS2 Protein
+Inquiry
Cat.#:PTGS2-4016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGS2
+Inquiry
Cat.#:PTGS2-643HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2 cell lysate
+Inquiry

Involved Pathway

PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CYP2B6; PTGES; PTGES2; GGT1; FAM213B; ALOX12; CYP1B1; PLA2G12A; ALOX5; PLA2G2E
Metabolic pathways
MTHFD1L; BCAT2; ACSS3; IDH3B; HSD3B7; NTPCR; PLA2G2E; RPN1; Atp5g2; ATP5I
NF-kappa B signaling pathway
PTGS2; IL-8; TRAF1; TNFSF11; UBE2I; BTK; CD40; MYD88; CCL21B; CFLAR
VEGF signaling pathway
MAP2K2A; PTK2AB; HRAS; PRKCA; PLA2G4D; AKT3A; MAPK12; PTGS2A; MAPK13; PPP3CB
TNF signaling pathway
NFKB1; MAP3K14; DNM1L; LTA; MLKL; IKBKG; MAPK1; RPS6KA4; IL6; IL1B
Retrograde endocannabinoid signaling
RIMS1; PRKACG; GABRQ; Adcy4; GNAI3; GABRB3; MAPK3; PRKCB; GABRE; GRM5
Serotonergic synapse
HTR1B; GNG4; ALOX12E; KCND2; CYP2C37; Casp3; GNG5; MAOA; CYP2C50; HTR5A
Ovarian steroidogenesis
GDF9; HSD17B2; LHCGR; GNAS; ACOT2; PTGS2; HSD3B6; Adcy4; HSD3B1; PLA2G4F
Oxytocin signaling pathway
PRKCB; NOS3; CACNB4; PRKACA; PIK3R3; CALM1; MYLK2; RAF1; PPP1CC; GNAS
Regulation of lipolysis in adipocytes
ABHD5; TSHR; PNPLA2; AQP7; IRS1; INS2; PIK3R2; NPY; Adcy4; INSR
Leishmaniasis
TGFB1; IL12B; NFKBIA; NOS2; MAPK12; HLA-DRB1; RELA; HLA-DRB5; ITGA4; IFNGR2
Pathways in cancer
KRAS; LAMA2; WNT8A; CCNE2; FGF9; WNT7A; PIK3CD; RXRA; NOS2; BCL2
Chemical carcinogenesis
CYP2C55; CCBL1; UGT1A7; ARNT; GSTA5; ALDH3B1; CYP2C37; UGT2B15; UGT2A1; GSTT2B
MicroRNAs in cancer
MARCKS; BMF; DNMT3A; ABCB1A; PLCG2; MMP9; EP300; EZH2; STAT3; IGF2BP1
Small cell lung cancer
BIRC2; LAMA1; LAMA2; CYCS; PIK3CA; CASP9; LAMC1; CKS2; LAMB2; TP53

Protein Function

PTGS2 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.
Function
Related Protein
Function dioxygenase activity
Related Protein KDM6B; KDM4C; OGFOD3; KDM4B; JMJD5; KDM6A; BCO1; ASPHD1; ALOX8; MINA
Function heme binding
Related Protein EPX; CYGB1; CYP4F11; CYP2AA3; CYP2W1; CYP46A1.4; CYP2A12; CYP2P9; CYP4B1; CYP2C39
Function lipid binding
Related Protein Alb; Fert2; LPAR4; PPARA; CRABP2B; ALOX15B; ACOT12; APOL2; FABP10A; FABP7B
Function metal ion binding
Related Protein NR5A1A; SP9; CYP2AA3; ZIC1; ZNF330; NRXN1A; ALPL; ADAMTS16; CYP19A1B; GMIP
Function peroxidase activity
Related Protein PTGS1; PTGS2B; GPX5; GPX4B; GPX7; PTGS2A; MPO; GPX4A; GPX1B; IPCEF1
Function prostaglandin-endoperoxide synthase activity
Related Protein PTGS2B; PTGS2; PTGS1; PTGS2A

Interacting Protein

PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.
arachidonic acid; ns398; q9wmx2-pro_0000037550; LRRK2

PTGS2 Related Articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).