ptgs2
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  • Official Full Name
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Background
  • Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2.
  • Synonyms
  • Ptgs2; prostaglandin-endoperoxide synthase 2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase, Tis10
Cat.#:PTGS2-26360THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PTGS2, His-tagged
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Cat.#:PTGS2-30HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, His-tagged
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Cat.#:PTGS2-32HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, FLAG/His-tagged
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Cat.#:PTGS2-523HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2
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Cat.#:PTGS2-677HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
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Cat.#:PTGS2-678HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
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Cat.#:PTGS2-857HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2, His tagged
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Cat.#:PTGS2-13651MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTGS2 Protein
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Cat.#:Ptgs2-679MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptgs2 protein, His-tagged
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Cat.#:PTGS2-4817RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGS2 Protein
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Cat.#:PTGS2-4016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGS2
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Cat.#:PTGS2-643HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2 cell lysate
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Involved Pathway

PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
GGT5A; PLA2G6; PLA2G4A; ALOX5B.3; CYP4A12A; ALOX12E; AKR1C21; CYP2C45; CYP2B6; CBR1L
Metabolic pathways
ATP5A1; PON3; NFS1; NDUFS4; SLC33A1; IDO2; GAL3ST1A; HGD; ALDOAA; PGM3
NF-kappa B signaling pathway
IL1R1; TNFRSF13C; LTA; CFLAR; MAP3K7IP3; TRAF3; TAB2; ATM; CCL4; SYK
VEGF signaling pathway
RAF1; PIK3R5; AKT2L; HSPB1; RAC3; RAC3A; AKT1; NOS3; MAPK13; BADB
TNF signaling pathway
MAPK1; DNM1L; PIK3R3; TNF; CREB3L1; RPS6KA4; ITCH; IL6; MAP2K3; MAPK8
Retrograde endocannabinoid signaling
MAPK9; GABRA3; GNG11; GABRQ; GABRA2; PRKCA; GRIA1; PRKACG; GNG5; GABRB3
Serotonergic synapse
GNAO1; GABRB2; GNG12; ITPR1; GNB1; ITPR3; KCNN2; PRKCG; HTR2B; HTR7
Ovarian steroidogenesis
ALOX5; BMP6; HSD3B1; PRKACG; GDF9; HSD3B4; PRKACA; CYP2J6; ACOT2; PLA2G4F
Oxytocin signaling pathway
CALML5; PLA2G4F; MAP2K2; PLCB2; PLCB3; ACTB; CACNG8; CAMK2A; PLA2G4A; PLA2G4C
Regulation of lipolysis in adipocytes
INSR; GNAI1; GNAS; TSHR; PIK3CB; PLIN1; PRKACA; IRS2; NPY1R; PRKG1
Leishmaniasis
HLA-DQB1; FCGR4; IL12B; Itgam&Itgb2; PRKCB; HLA-DOA; FOS; MYD88; FCGR3; NOS2
Pathways in cancer
RET; IKBKG; PIK3R2; WNT9A; PTEN; FOS; CKS2; WNT11; PLCG2; GNAI3
Chemical carcinogenesis
GSTA4; MGST1; EPHX1; GSTM5; UGT1A7; SULT1A4; NAT2; CYP2C19; CYP3A4; AHA-1
MicroRNAs in cancer
EZH2; IRS2; NOTCH2; CDC25C; NRAS; ABL1; TIMP3; RAF1; WNT3; DNMT1
Small cell lung cancer
TRAF5; PIAS2; TRAF1; TP53; CCNE2; PIK3R5; RXRB; CASP9; FN1; ITGB1

Protein Function

PTGS2 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.
Function
Related Protein
Function dioxygenase activity
Related Protein ALKBH7; ALOX12E; KDM4C; TDO2B; PTGS2; KDM6B; HPDA; OGFOD2; BCO2L; PLOD1A
Function heme binding
Related Protein CYP2X7; CYB5D2; NENF; LPO; CYP2E1; HBB; MPO; CYP1C1; CYP7B1; CYP46A1.1
Function lipid binding
Related Protein CYP21A1; OSBPL9; CYTH1; APOL3; PAQR5B; ACBD6; GLTP; S1PR2; APOA4B.2; BAD
Function metal ion binding
Related Protein CYP11C1; NR1H5; ASXL1; ZFP354C; GFI1AB; DNAJA2; E4F1; INO80B; ZCCHC18; CYGB1
Function peroxidase activity
Related Protein EPX; PTGS1; IPCEF1; PXDN; MPX; GPX4B; GPX5; GPX1A; MGST3; CYGB
Function prostaglandin-endoperoxide synthase activity
Related Protein PTGS2A; PTGS1; PTGS2; PTGS2B

Interacting Protein

PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.
arachidonic acid; ns398; q9wmx2-pro_0000037550; LRRK2

PTGS2 Related Articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).