ptgs2
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  • Official Full Name
  • prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
  • Background
  • Cytochrome c oxidase subunit II, also known as COX2, is a human protein and gene. that belongs to cytochrome c oxidase subunit II protein family. It is sometimes confused with the cyclooxygenase enzyme COX-2.
  • Synonyms
  • Ptgs2; prostaglandin-endoperoxide synthase 2; COX2; Cox-2; PHS-2; Pghs2; TIS10; PGHS-2; PES-2; PHS II; gripghs; PGH synthase 2; cyclooxygenase 2; cyclooxygenase-2; prostaglandin H2 synthase 2; glucocorticoid-regulated inflammatory cyclooxygenase; macrophage activation-associated marker protein P71/73; prostaglandin G/H synthase, Tis10
Cat.#:PTGS2-26360THTag:His
Source (Host):Species:Human
Product nameRecombinant Human PTGS2, His-tagged
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Cat.#:PTGS2-30HTag:His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, His-tagged
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Cat.#:PTGS2-32HTag:FLAG/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2 protein, FLAG/His-tagged
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Cat.#:PTGS2-523HTag:N/A
Source (Host):Sf 21 Insect cellsSpecies:Human
Product nameRecombinant Human PTGS2
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Cat.#:PTGS2-677HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
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Cat.#:PTGS2-678HTag:His/T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PTGS2 protein, His & T7-tagged
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Cat.#:PTGS2-857HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2, His tagged
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Cat.#:PTGS2-13651MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse PTGS2 Protein
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Cat.#:Ptgs2-679MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptgs2 protein, His-tagged
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Cat.#:PTGS2-4817RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTGS2 Protein
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Cat.#:PTGS2-4016CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken PTGS2
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Cat.#:PTGS2-643HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTGS2 cell lysate
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Involved Pathway

PTGS2 involved in several pathways and played different roles in them. We selected most pathways PTGS2 participated on our site, such as Arachidonic acid metabolism, Metabolic pathways, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTGS2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Arachidonic acid metabolism
CBR3; PTGES2; PLA2G6; GGTLC1; ALOX12; PLA2G1B; PTGES; CYP2U1; TBXAS1; CYP2P9
Metabolic pathways
GALT; GANC; TKT; TPH1B; ALPI; CYP2B19; GLCEA; TYRP1; GALCA; HPRT1
NF-kappa B signaling pathway
TNFSF13B; BIRC3; BCL2A1A; PIDD1; Ccl21c; LRDD; MYD88; CFLAR; TRAF2; MAP3K14
VEGF signaling pathway
PXNA; RAC1; PLCG1; PTGS2; PIK3R5; HRAS; PTGS2B; RAC1B; SPHK1; PPP3CCA
TNF signaling pathway
MAP3K7; TNF; IL18R1; MAP3K5; PIK3CA; MAGI2; PIK3CG; PIK3R2; DNM1L; MAPK11
Retrograde endocannabinoid signaling
GABRP; GRIA4; ITPR3; Adcy4; GABRG3; GNGT2; GNB1; GABRA3; GNG4; GRM5
Serotonergic synapse
MAOA; SLC18A1; PRKACG; CYP2D9; KRAS; PLCB2; ALOX12E; PTGS1; Casp3; PLA2G4A
Ovarian steroidogenesis
Adcy4; INSR; INS1; PRKACG; LHB; INS2; STAR; HSD3B5; SCARB1; INS
Oxytocin signaling pathway
PLA2G4D; MYL6; CACNA2D2; PRKAB2; GNAS; NOS3; PIK3CD; MYL9; NFATC1; PIK3R3
Regulation of lipolysis in adipocytes
NPR1; TSHB; PRKACB; PIK3R1; PRKG1; PIK3R5; PIK3CA; PIK3CB; PIK3R3; INS1
Leishmaniasis
STAT1; HLA-DMB; IFNG; MYD88; FCGR2A; MAPK11; HLA-DQA1; H2-AA; NFKB1; FCGR3A
Pathways in cancer
LAMB4; CASP9; DAPK1; LAMC2; HDAC1; ITGAV; TCEB2; Fzd4; GNAI2; PTEN
Chemical carcinogenesis
GSTM7; NAT1; ADH1B; GSTT1; UGT1A6; ADH4; ALDH3B1; NAT2; UGT1A6A; CYP2C8
MicroRNAs in cancer
SPRY2; WNT3; DNMT3A; TNXB; Pdgfa&Pdgfb; RECK; ABCB1A; CCND1; TRP63; PLAU
Small cell lung cancer
TRAF5; LAMB2; TP53; ITGA6; PIK3CG; AKT2; TRAF6; BCL2; LAMC1; BCL2L1

Protein Function

PTGS2 has several biochemical functions, for example, dioxygenase activity, heme binding, lipid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTGS2 itself. We selected most functions PTGS2 had, and list some proteins which have the same functions with PTGS2. You can find most of the proteins on our site.
Function
Related Protein
Function dioxygenase activity
Related Protein KDM4C; KDM4B; ADOA; ASPHD1; HPDA; P4HA1B; ALOX5B.3; KDM3A; ALKBH6; ASPHD2
Function heme binding
Related Protein CYP4F22; HBAA; CYP4F18; CYP2X9; CYP2AA4; CYP2Y3; XGB; CYP4X1; CYP1A1; CYP2AA2
Function lipid binding
Related Protein FABP10A; FABP1A; PAQR5B; FABP12; LTC4S; LIPF; CHMP4A; APOA5; EPN3; FABP11A
Function metal ion binding
Related Protein LDB3A; ZNF643; PICK1; ARSD; PLEKHF1; NPTX2; NUFIP1; TROVE2; GLRX2; HBAE1
Function peroxidase activity
Related Protein PTGS2; GPX4B; PXDN; DUOX2; TPO; GPX7; PTGS2B; GPX8; GPX6; PRDX5
Function prostaglandin-endoperoxide synthase activity
Related Protein PTGS1; PTGS2A; PTGS2B; PTGS2

Interacting Protein

PTGS2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTGS2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTGS2.
arachidonic acid; ns398; q9wmx2-pro_0000037550; LRRK2

PTGS2 Related Articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Jang, YJ; Park, JI; et al. Cumulus Cell-Expressed Type I Interferons Induce Cumulus Expansion in Mice. BIOLOGY OF REPRODUCTION 92:-(2015).