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Recombinant Human PTGS2 Protein (18-601 aa), His-tagged

Cat.No. : PTGS2-752H
Product Overview : Recombinant Human PTGS2 Protein (18-601 aa) is produced by E. coli expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Metabolism. Protein Description: Partial.
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  • Gene Information
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Description : Converts arachidonate to prostaglandin H2 (PGH2), a committed step in prostanoid synthesis. Constitutively expressed in some tissues in physiological conditions, such as the endothelium, kidney and brain, and in pathological conditions, such as in cancer. PTGS2 is responsible for production of inflammatory prostaglandins. Up-regulation of PTGS2 is also associated with increased cell adhesion, phenotypic changes, resistance to apoptosis and tumor angiogenesis. In cancer cells, PTGS2 is a key step in the production of prostaglandin E2 (PGE2), which plays important roles in modulating motility, proliferation and resistance to apoptosis.
Source : E. coli
Species : Human
Tag : His
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 70.9 kDa
Protein length : 18-601 aa
AA Sequence : ANPCCSHPCQNRGVCMSVGFDQYKC DCTRTGFYGENCSTPEFLTRIKLFL KPTPNTVHYILTHFKGFWNVVNNIP FLRNAIMSYVLTSRSHLIDSPPTYN ADYGYKSWEAFSNLSYYTRALPPVP DDCPTPLGVKGKKQLPDSNEIVEKL LLRRKFIPDPQGSNMMFAFFAQHFT HQFFKTDHKRGPAFTNGLGHGVDLN HIYGETLARQRKLRLFKDGKMKYQI IDGEMYPPTVKDTQAEMIYPPQVPE HLRFAVGQEVFGLVPGLMMYATIWL REHNRVCDVLKQEHPEWGDEQLFQT SRLILIGETIKIVIEDYVQHLSGYH FKLKFDPELLFNKQFQYQNRIAAEF NTLYHWHPLLPDTFQIHDQKYNYQQ FIYNNSILLEHGITQFVESFTRQIA GRVAGGRNVPPAVQKVSQASIDQSR QMKYQSFNEYRKRFMLKPYESFEEL TGEKEMSAELEALYGDIDAVELYPA LLVEKPRPDAIFGETMVEVGAPFSL KGLMGNVICSPAYWKPSTFGGEVGF QIINTASIQSLICNNVKGCPFTSFS VPDPELIKTVTINASSSRSGLDDIN PTVLLKERS
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
Gene Name : PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) [ Homo sapiens ]
Official Symbol : PTGS2
Synonyms : PTGS2; COX2; PHS II; COX-2; PHS-2; PGG/HS; PGHS-2; hCox-2; GRIPGHS;
Gene ID : 5743
mRNA Refseq : NM_000963
Protein Refseq : NP_000954
MIM : 600262
UniProt ID : P35354

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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