ptk2b
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  • Official Full Name
  • protein tyrosine kinase 2 beta
  • Background
  • This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PTK2B; protein tyrosine kinase 2 beta; PKB; PTK; CAKB; FAK2; PYK2; CADTK; FADK2; RAFTK; protein-tyrosine kinase 2-beta; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; cell adhesion kinase beta; proline-rich tyrosine kinase 2; calcium-dependent tyrosine kinase; PTK2B protein tyrosine kinase 2 beta; related adhesion focal tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase;
Cat.#:PTK2B-1903HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, GST-tagged
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Cat.#:PTK2B-1904HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, His-tagged
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Cat.#:PTK2B-570HTag:His
Source (Host):Sf 9 insect cellsSpecies:Human
Product nameRecombinant Human PTK2B, His-tagged
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Cat.#:PTK2B-743HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human PTK2B, GST-tagged
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Cat.#:PTK2B-74HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human PTK2B protein, Flag-tagged, Biotinylated
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Cat.#:Ptk2b-6813MTag:His|GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ptk2b protein, His & GST-tagged
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Cat.#:PTK2B-4823RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PTK2B Protein
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Cat.#:PTK2B-414HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2B, His-tagged, Active
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Cat.#:PTK2B-701HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human PTK2B Protein Tyrosine Kinase 2 Beta, GST-His
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Cat.#:PTK2B-2698HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human PTK2B 293 Cell Lysate
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Involved Pathway

PTK2B involved in several pathways and played different roles in them. We selected most pathways PTK2B participated on our site, such as Calcium signaling pathway, Chemokine signaling pathway, Phospholipase D signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTK2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcium signaling pathway
P2RX3; TMEM8C; P2RX5; PLCB4; ADRB3; MYLK2; AGTR1B; BDKRB1; CHRM1; PDE1C
Chemokine signaling pathway
CXCL2; PRKCD; GM13304; CXCR2; GRK6; NFKB1; CXCL12; XCL2; CCL2; PIK3R3
Phospholipase D signaling pathway
PLA2G4F; AGPAT5; RALGDS; MAP2K1; LPAR2; LPAR4; PDGFC; GRM7; SHC3; PIK3CD
Natural killer cell mediated cytotoxicity
IFNG; IFNGR2; PPP3R1; IFNA7; ICAM1; IFNA16; Ifna15; KIR2DL4; ICAM2; RAC3
Leukocyte transendothelial migration
MYL12B; CLDN6; CXCL12; MAPK13; AASS; PIK3R2; JAM3; CLDN4; BCAR1; CTNNA3
GnRH signaling pathway
NRAS; PRKACAB; MAP2K6; RAF1; CACNA1DA; CALM1; MAP3K1; GNA11B; ADCY1A; SRC
Hepatitis B
TNF; SMAD4; PIK3CB; TGFB1; NFKBIA; ATF4; RAF1; STAT4; IL6; Ifna11

Protein Function

PTK2B has several biochemical functions, for example, 3-phosphoinositide-dependent protein kinase binding, ATP binding, contributes_to NMDA glutamate receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTK2B itself. We selected most functions PTK2B had, and list some proteins which have the same functions with PTK2B. You can find most of the proteins on our site.
Function
Related Protein
Function 3-phosphoinositide-dependent protein kinase binding
Related Protein PTK2B
Function ATP binding
Related Protein PINK1; SLFNL1; SMG1; CLK3; PMS2; AK9; POMK; UBE2F; CAMK2D2; ABCF2A
Function contributes_to NMDA glutamate receptor activity
Related Protein GRIN1; GRIN3A; PTK2B; GRIN2A
Function calmodulin-dependent protein kinase activity
Related Protein CAMK2D; MAPKAPK2; DAPK2A; CAMK1; MKNK1; CAMK1D; CAMK2B; PTK2B; CAMKK2; DAPK1
Function non-membrane spanning protein tyrosine kinase activity
Related Protein PTK2B; LYN; TNK2; ZNF143B; PTK6; TNK2B; FYN; CLK1; FYNA; FYNB
Function protein binding
Related Protein CUTA; CCDC86; TAP1; LRRC4B; KLK5; MYC; ATL1; PTGER4; TCF4; LINGO1B
Function protein complex binding
Related Protein KRIT1; AP2B1; DLG4; GRIN2A; ARRB2; PRKACA; CDK4; NFKBIA; NFYB; KRT8
Function protein tyrosine kinase activity
Related Protein IGF1RB; EPHB4B; IGF1R; MAP2K4; BCR; ROS1; TEK; BLK; TYK2; BAZ1B
Function receptor binding
Related Protein CLCF1; IL29; DIAPH1; AGRP2; TIGIT; GLA; DRD1A; ALCAM; NPFF; TNFSF18
Function signal transducer activity
Related Protein TAAR14G; PLK2; SUFU; OLFR492; FPR3; OLFR494; VALOPA; TICAM1; STAT2; HCAR1-1

Interacting Protein

PTK2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTK2B here. Most of them are supplied by our site. Hope this information will be useful for your research of PTK2B.
SRC; RHOU; FYN; MATK; MAP3K4; ERBB2; HSP90AB1; PDCD6IP; MYD88; yopM; q8ckf8_yerpe; q8ckm0_yerpe