Recombinant Human PTK2B protein, Flag-tagged, Biotinylated

• Cat.No.: PTK2B-74H
• Product Overview: Recombinant Human PYK2 [1-967(end) amino acids of accession number NP_775267.1] fused with DYKDDDDK tag at N-terminal was expressed in insect cell and biotinylated.

Specification

• Source: Insect cell
• Species: Human
• Tag: Flag
• Form: 50 mM Tris-HCl, 150 mM NaCl, 0.05% Brij35, 1 mM DTT, 10% glycerol, pH7.5
• Molecular Mass: 115 kDa
• Purity: >90% as determined by SDS-PAGE and CBB staining
• Storage: Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: PTK2B PTK2B protein tyrosine kinase 2 beta [ Homo sapiens ]
• Official Symbol: PTK2B
• Synonyms: PTK2B; PTK2B protein tyrosine kinase 2 beta; CADTK; CAKB; PTK; PYK2; RAFTK; FADK 2; CAK-beta; protein kinase B; focal adhesion kinase 2; PKB; FAK2; FADK2
• Gene ID: 2185
• mRNA Refseq: NM_004103
• Protein Refseq: NP_004094
• MIM: 601212
• UniProt ID: Q14289
• Chromosome Location: 8p21.1
• Pathway: Alpha-synuclein signaling, organism-specific biosystem; B Cell Receptor Signaling Pathway, organism-specific biosystem; CXCR4-mediated signaling events, organism-specific biosystem; Calcium signaling pathway, organism-specific biosystem; Calcium signaling pathway, conserved biosystem; Cell-Cell communication, organism-specific biosystem; Chemokine signaling pathway, organism-specific biosystem
• Function: 3-phosphoinositide-dependent protein kinase binding; ATP binding; binding; non-membrane spanning protein tyrosine kinase activity; nucleotide binding; protein binding; protein tyrosine kinase activity; protein tyrosine kinase activity; signal transducer activity

Reviews

11/10/2021

PTK2B protein is highly recommended for researchers, as it demonstrates excellent performance in WB experiments and has proven useful in protein electron microscopy structure analysis.

04/28/2021

PTK2B protein is highly recommended for researchers due to its excellent performance in various assays, particularly in Western blotting (WB) experiments, and its applicability in protein electron microscopy structure analysis.

07/04/2018

It enables accurate detection and quantification of PTK2B protein levels in samples, providing crucial insights into its expression, regulation, and potential functional changes under different experimental conditions.

Q&As

How is PTK2B protein expression measured in clinical settings?

PTK2B protein expression can be assessed using techniques like Western blotting and immunohistochemistry.

What are the challenges in developing PTK2B-targeted therapies?

One of the challenges is achieving specificity in targeting PTK2B without affecting other related proteins or pathways.

Are there any drugs that target PTK2B protein?

Several small molecule inhibitors targeting PTK2B are being developed as potential therapeutics for cancer and other diseases.

Can PTK2B protein be used as a diagnostic marker for any diseases?

PTK2B protein expression has been explored as a potential diagnostic marker for certain cancers and neurodegenerative disorders.

Can PTK2B protein be targeted for therapeutic purposes?

Yes, PTK2B is a potential therapeutic target for cancer, neurodegenerative diseases, and cardiovascular conditions.