Description : |
This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. |
Source : |
HEK293 |
Species : |
Human |
Tag : |
Myc/DDK |
Molecular Mass : |
115.9 kDa |
AA Sequence : |
MSGVSEPLSRVKLGTLRRPEGPAEP MVVVPVDVEKEDVRILKVCFYSNSF NPGKNFKLVKCTVQTEIREIITSIL LSGRIGPNIRLAECYGLRLKHMKSD EIHWLHPQMTVGEVQDKYECLHVEA EWRYDLQIRYLPEDFMESLKEDRTT LLYFYQQLRNDYMQRYASKVSEGMA LQLGCLELRRFFKDMPHNALDKKSN FELLEKEVGLDLFFPKQMQENLKPK QFRKMIQQTFQQYASLREEECVMKF FNTLAGFANIDQETYRCELIQGWNI TVDLVIGPKGIRQLTSQDAKPTCLA EFKQIRSIRCLPLEEGQAVLQLGIE GAPQALSIKTSSLAEAENMADLIDG YCRLQGEHQGSLIIHPRKDGEKRNS LPQIPMLNLEARRSHLSESCSIESD IYAEIPDETLRRPGGPQYGIAREDV VLNRILGEGFFGEVYEGVYTNHKGE KINVAVKTCKKDCTLDNKEKFMSEA VIMKNLDHPHIVKLIGIIEEEPTWI IMELYPYGELGHYLERNKNSLKVLT LVLYSLQICKAMAYLESINCVHRDI AVRNILVASPECVKLGDFGLSRYIE DEDYYKASVTRLPIKWMSPESINFR RFTTASDVWMFAVCMWEILSFGKQP FFWLENKDVIGVLEKGDRLPKPDLC PPVLYTLMTRCWDYDPSDRPRFTEL VCSLSDVYQMEKDIAMEQERNARYR TPKILEPTAFQEPPPKPSRPKYRPP PQTNLLAPKLQFQVPEGLCASSPTL TSPMEYPSPVNSLHTPPLHRHNVFK RHSMREEDFIQPSSREEAQQLWEAE KVKMRQILDKQQKQMVEDYQWLRQE EKSLDPMVYMNDKSPLTPEKEVGYL EFTGPPQKPPRLGAQSIQPTANLDR TDDLVYLNVMELVRAVLELKNELCQ LPPEGYVVVVKNVGLTLRKLIGSVD DLLPSLPSSSRTEIEGTQKLLNKDL AELINKMRLAQQNAVTSLSEECKRQ MLTASHTLAVDAKNLLDAVDQAKVL ANLAHPPAETRTRPLEQKLISEEDL AANDILDYKDDDDKV |
Purity : |
> 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : |
Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : |
Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : |
50 μg/mL as determined by BCA |
Storage Buffer : |
100 mM glycine, 25 mM Tris-HCl, pH 7.3. |