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PTP4A2

  • Official Full Name

    protein tyrosine phosphatase type IVA, member 2

  • Overview

    The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are;cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a;protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been;shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was;found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a;regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which;suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related;pseudogenes exist on chromosomes 11, 12 and 17.
  • Synonyms

    PTP4A2; protein tyrosine phosphatase type IVA, member 2; PTP4A; protein tyrosine phosphatase type IVA 2; HU PP 1; OV 1; PRL 2; ptp IV1a; PTPCAAX2; PTP(CAAXII); protein tyrosine phosphatase IVA; protein-tyrosine phosphatase 4a2; protein tyrosine phosphatase IVA2; phosphatase of regenerating liver 2; protein-tyrosine phosphatase of regenerating liver 2; HH13; OV-1; PRL2; HH7-2; PRL-2; HU-PP-1; ptp-IV1a; ptp-IV1b;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • E. coli
  • E.coli
  • HEK293
  • HEK293T
  • Mammalian Cell
  • Sf9 Insect Cell
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PTP4A2-1907H Active Recombinant Human PTP4A2 protein, His-tagged E.coli His aa 2-167
Human PTP4A2-505H Recombinant Human PTP4A2(2-167), His-tagged E.coli N/A
Human PTP4A2-449H Recombinant Human PTP4A2, GST-tagged Sf9 Insect Cell GST
Human PTP4A2-2801H Recombinant Human PTP4A2, His-tagged E.coli His
Human PTP4A2-2546H Recombinant Human PTP4A2 protein(Asn2-Gln167), GST-tagged E. coli N-GST Asn2-Gln167
Human PTP4A2-675H Recombinant Human PTP4A2, GST-tagged E.coli GST
Human PTP4A2-545H Recombinant Human PTP4A2 Mammalian Cell His
Human PTP4A2-2694HCL Recombinant Human PTP4A2 293 Cell Lysate HEK293 N/A
Human PTP4A2-3944H-B Recombinant Human PTP4A2 Protein Pre-coupled Magnetic Beads HEK293
Human PTP4A2-6608H Recombinant Human PTP4A2 Protein (Met1-Gln167), C-His tagged E.coli C-His Met1-Gln167
Human PTP4A2-3944H Recombinant Human PTP4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Ptp4a2-5231M Recombinant Mouse Ptp4a2 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat PTP4A2-4828R Recombinant Rat PTP4A2 Protein Mammalian Cell His
Rat PTP4A2-4487R Recombinant Rat PTP4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PTP4A2-4487R-B Recombinant Rat PTP4A2 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque PTP4A2-3698R Recombinant Rhesus monkey PTP4A2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque PTP4A2-3515R Recombinant Rhesus Macaque PTP4A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque PTP4A2-3515R-B Recombinant Rhesus Macaque PTP4A2 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • PTP4A2 Related Articles
  • PTP4A2 Related Research Area

PTP4A2 involved in several pathways and played different roles in them. We selected most pathways PTP4A2 participated on our site, such as Signaling events mediated by PRL, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTP4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Signaling events mediated by PRLLRP8;ATF5;RABGGTA;RABGGTB;PTP4A2;PTP4A3;PTP4A1

PTP4A2 has several biochemical functions, for example, prenylated protein tyrosine phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PTP4A2 itself. We selected most functions PTP4A2 had, and list some proteins which have the same functions with PTP4A2. You can find most of the proteins on our site.

Function Related Protein
prenylated protein tyrosine phosphatase activityPTP4A3;PTP4A2

PTP4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTP4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTP4A2.

TNFAIP8; EPHB2; FNTA; FNTB; USF2; CNNM3; PTP4A1; MLH1; Kif21b; CDK2

Wu, S; Kanda, T; et al. Knockdown of Receptor-Interacting Serine/Threonine Protein Kinase-2 (RIPK2) Affects EMT-associated Gene Expression in Human Hepatoma Cells. ANTICANCER RESEARCH 32:3775-3783(2012).
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