Recombinant Human PTP4A2, His-tagged

• Cat.No.: PTP4A2-2801H
• Product Overview: Recombinant human PTP4A2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques. MW =23.2 kDa (203aa), confirmed by MALDI-TOF.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: Protein tyrosine phosphatase type IVA 2 isoform 1, also known as PTP4A2, belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTP4A2 is localized to the early endosome that play regulatory roles in a variety of cellular processes. This protein was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis.
• Sequences Of Amino Acids: MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMNRP APVEISYENM RFLITHNPTN ATLNKFTEEL KKYGVTTLVR VCDATYDKAP VEKEGIHVLD WPFDDGAPPP NQIVDDWLNL LKTKFREEPG CCVAVHCVAG LGRAPVLVAL ALIECGMKYE DAVQFIRQKR RGAFNSKQLL YLEKYRPKMR LRFRDTNGHC CVQ
• Purity: > 90% by SDS - PAGE.
• Form: Liquid. In 20mM Tris-HCl buffer (pH 8.0) containing 1mM DTT, 10% glycerol.
• Concentration: 0.5 mg/ml (determined by Bradford assay).
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: PTP4A2 protein tyrosine phosphatase type IVA, member 2 [ Homo sapiens ]
• Synonyms: PTP4A2; protein tyrosine phosphatase type IVA, member 2; HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b; Protein tyrosine phosphatase type IVA 2; EC 3.1.3.48; Protein-tyrosine phosphatase 4a2; BM-008; Protein-tyrosine phosphatase of regenerating liver 2
• Gene ID: 8073
• mRNA Refseq: NM_080391
• Protein Refseq: NP_536316
• MIM: 601584
• UniProt ID: Q12974
• Chromosome Location: 1p35
• Function: prenylated protein tyrosine phosphatase activity; hydrolase activity; protein binding