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PTPN4

Official Full Name

protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
Overview

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. This PTP has been shown to interact with glutamate receptor delta 2 and epsilon subunits, and is thought to play a role in signalling downstream of the glutamate receptors through tyrosine dephosphorylation. [provided by RefSeq, Jul 2008]
Synonyms

PTPN4; protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte); MEG; PTPMEG; PTPMEG1; tyrosine-protein phosphatase non-receptor type 4; PTPase-MEG1; megakaryocyte phosphatase; protein tyrosine phosphatase MEG1; protein-tyrosine phosphatase MEG1; megakaryocyte protein-tyrosine phosphatase;

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Human
Rhesus Macaque

Source

E. coli
E.coli
HEK293
Mammalian Cell

Tag

GST
His
His (Fc)
Avi
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PTPN4-207H	Active Recombinant Human PTPN4(423-end) Protein, N-GST-tagged	E. coli	GST	423-end	Inquiry
Human	PTPN4-603H	Recombinant Human PTPN4, GST-tagged	E.coli	GST		Inquiry
Human	PTPN4-2005H	Recombinant Human PTPN4 Protein, His&GST-tagged	E.coli	N-His&GST	Asn616-Lys926	Inquiry
Human	PTPN4-683H	Recombinant Human PTPN4 protein, GST-tagged	E. coli	GST	604-927 aa	Inquiry
Rhesus Macaque	PTPN4-3707R	Recombinant Rhesus monkey PTPN4 Protein, His-tagged	Mammalian Cell	His		Inquiry
Rhesus Macaque	PTPN4-3524R	Recombinant Rhesus Macaque PTPN4 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rhesus Macaque	PTPN4-3524R-B	Recombinant Rhesus Macaque PTPN4 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry

Involved Pathway
Protein Function
Interacting Protein

PTPN4 involved in several pathways and played different roles in them. We selected most pathways PTPN4 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPN4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein

PTPN4 has several biochemical functions, for example, cytoskeletal protein binding, non-membrane spanning protein tyrosine phosphatase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPN4 itself. We selected most functions PTPN4 had, and list some proteins which have the same functions with PTPN4. You can find most of the proteins on our site.

Function	Related Protein
cytoskeletal protein binding	PTPN4A;SLC8A1;CAPN1;FRMD3;TOR1AIP1;EZRA;CAPN2;EZRB;B4GALT1
non-membrane spanning protein tyrosine phosphatase activity	PTPN12;PTPN4;PTPN11;PTPN9;PTPN18;ACP1;DUSP1
protein binding	SRPK2;IRAK1;FBXW2;LARP7;GYG1;OSBPL3;RBMY1B;NOS3;FOXO3B

PTPN4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPN4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPN4.

CRK; KAT5; MAPK12; ABL1; FYN; NCK1; PIK3R1; GRB2; ZZEF1; TK1; LPL; EEF1G; ATRX; EEF1A1