|Official Full Name||pumilio homolog 1|
|Background||This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3 untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described.|
|Synonyms||PUM1; pumilio homolog 1 (Drosophila); pumilio (Drosophila) homolog 1; pumilio homolog 1; KIAA0099; PUMH1; pumilio-1; PUMH; HSPUM; PUML1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
PUM1 involved in several pathways and played different roles in them. We selected most pathways PUM1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with PUM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Clathrin derived vesicle budding||PLDN; TBC1D8B; AP1M2; CNO; SH3D19; DNASE2; AP4B1; SNAPIN; CLVS1; BLOC1S1|
|Golgi Associated Vesicle Biogenesis||PLDN; AP1M2; FTH1B; GAK; AP4B1; PICALMA; NECAP1; HIP1R; TFR1B; CLINT1|
|Membrane Trafficking||DTNBP1; TRAPPC6B; CPD; TERFA; ARCN1; TRAPPC5; NSFA; BLOC1S6; TRAPPC2; CNO|
|Vesicle-mediated transport||SNF8; MIA3; ARCN1; CLVS1; FTH1A; PUM1; AP4B1; HYOU1; TERFA; CD163|
|trans-Golgi Network Vesicle Budding||SNX9B; PICALMB; CPD; PICALM; PLDN; HIP1RB; TPD52; CLINT1; BLOC1S6; CLVS1|
PUM1 has several biochemical functions, for example, mRNA 3-UTR binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PUM1 itself. We selected most functions PUM1 had, and list some proteins which have the same functions with PUM1. You can find most of the proteins on our site.
|mRNA 3-UTR binding||CPEB2; PUM2; CPEB1; RBM24; KHSRP; RNF20; AUH; SERBP1; CPEB1B; RBM24A|
|poly(A) RNA binding||SYNCRIP; MTO1; DDX42; PYDC3; SNRPD2; LSM2; FNDC3A; RPL7A; EIF2AK2; RTCA|
|protein binding||TRAF7; AATF; TBXAS1; IGFBP5; MAPK9; MED25; DDOST; SLC30A8; RAD51; ISCA2|
PUM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PUM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PUM1.
ATXN1; EIF5; SMAD1; ppc; mutS; PRR12; PTBP3; VCAM1; YWHAB; ORF7; CDC5L; SAV1