PUM1
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Official Full Name
pumilio homolog 1
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Overview
This gene encodes a member of the PUF family, evolutionarily conserved RNA-binding proteins related to the Pumilio proteins of Drosophila and the fem-3 mRNA binding factor proteins of C. elegans. The encoded protein contains a sequence-specific RNA binding domain comprised of eight repeats and N- and C-terminal flanking regions, and serves as a translational regulator of specific mRNAs by binding to their 3 untranslated regions. The evolutionarily conserved function of the encoded protein in invertebrates and lower vertebrates suggests that the human protein may be involved in translational regulation of embryogenesis, and cell development and differentiation. Alternatively spliced transcript variants encoding different isoforms have been described. -
Synonyms
PUM1; pumilio homolog 1 (Drosophila); pumilio (Drosophila) homolog 1; pumilio homolog 1; KIAA0099; PUMH1; pumilio-1; PUMH; HSPUM; PUML1;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Zebrafish
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
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| Human | PUM1-31264TH | Recombinant Human PUM1, His-tagged | E.coli | His |
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| Human | PUM1-2069H | Recombinant Human PUM1 protein, His-tagged | E.coli | His | 825-1186 aa | |
| Human | PUM1-1445HCL | Recombinant Human PUM1 cell lysate | N/A |
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| Human | PUM1-2883H | Recombinant Human PUM1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Myc/DDK |
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| Human | PUM1-3159H | Recombinant Human PUM1 Protein, MYC/DDK-tagged | HEK293 | Myc/DDK |
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| Human | PUM1-930HFL | Recombinant Full Length Human PUM1 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | PUM1-1809H | Recombinant Human PUM1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | PUM1-1809H-B | Recombinant Human PUM1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | Pum1-5257M | Recombinant Mouse Pum1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Zebrafish | PUM1-8294Z | Recombinant Zebrafish PUM1 | Mammalian Cell | His |
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| Chicken | PUM1-2064C | Recombinant Chicken PUM1 | Mammalian Cell | His |
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- Involved Pathway
- Protein Function
- Interacting Protein
PUM1 involved in several pathways and played different roles in them. We selected most pathways PUM1 participated on our site, such as Clathrin derived vesicle budding, Golgi Associated Vesicle Biogenesis, Membrane Trafficking, which may be useful for your reference. Also, other proteins which involved in the same pathway with PUM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Clathrin derived vesicle budding | CLTC;BLOC1S4;TFR1B;CLVS2;NAPAA;AP4B1;DTNBP1;CTSZ;AP3S1 |
| Golgi Associated Vesicle Biogenesis | SNX9A;NAPAB;AP1S1;PICALM;PUM1;TGOLN2;AP4B1;NECAP1;FTH1B |
| Membrane Trafficking | GJB5;GJD3;TFR1B;SNX9;PREB;PLDN;ARCN1A;LMAN2L;TMED10 |
| Vesicle-mediated transport | TCEAL4;NFX1;HIP1R;TPD52;HP;CLVS1;TERFA;TRAPPC2;BLOC1S6 |
| trans-Golgi Network Vesicle Budding | DNASE2;PICALM;TGOLN2;DTNBP1B;CLVS1;NECAP1;AP4B1;CNO;PUM1 |
PUM1 has several biochemical functions, for example, mRNA 3-UTR binding, poly(A) RNA binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PUM1 itself. We selected most functions PUM1 had, and list some proteins which have the same functions with PUM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA 3-UTR binding | IGF2BP2;CSDA;CPEB1A;RBM4;RNPS1;KHSRP;ELAVL1;PUM2;CPEB1 |
| poly(A) RNA binding | IFI16;SF3B14;OTUD4;HNRNPU;XRCC5;PUS7;HNRNPC;POP7;NOP14 |
| protein binding | PIK3IP1;EEF1D;FOXP3;PRLR;AAK1;POSTN;SGCG;NAA35;PAM16 |
PUM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PUM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PUM1.
ATXN1; EIF5; SMAD1; ppc; mutS; PRR12; PTBP3; VCAM1; YWHAB; ORF7; CDC5L; SAV1
- Q&As
- Reviews
Q&As (6)
Ask a questionPUM1's structure determines its ability to bind to RNA and its post-transcriptional regulatory role. The study of its structure can help us understand its function and mechanism of action.
Recently published articles indicate that PUM1 expression levels are associated with the occurrence and development of certain cancers. High expression of PUM1 may promote tumor growth and spread.
Drug development for PUM1 requires consideration of its specificity, safety, pharmacokinetic properties, and potential side effects. In addition, issues such as the dosage form, route of administration and design of clinical trials need to be considered.
In cancer, PUM1 may play a role by promoting processes such as the growth, migration and invasion of tumor cells. It could be a potential target for cancer treatment.
It can interact with a variety of other proteins, including transcription factors and RNA-degrading enzymes. These interactions allow it to regulate the expression levels of specific genes.
Therapeutic strategies for PUM1 may include inhibiting its expression, blocking its binding to specific RNA sequences, or regulating its associated signal transduction pathways. These methods may have potential applications in cancer treatment.
Customer Reviews (3)
Write a reviewPUM1 performed well in the experiment and met my expectations.
PUM1 is reliable, reliable and reliable.
It has the expected biological activity, such as enzyme activity, receptor binding activity, etc., and performs well.
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