pcolce
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  • Official Full Name
  • procollagen C-endopeptidase enhancer
  • Background
  • Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase activity. [provided by RefSeq, Jul 2008]
  • Synonyms
  • PCOLCE; procollagen C-endopeptidase enhancer; PCPE; PCPE1; PCPE-1; procollagen C-endopeptidase enhancer 1; procollagen C-proteinase enhancer 1; procollagen COOH-terminal proteinase enhancer 1; type 1 procollagen C-proteinase enhancer protein; type I procollagen COOH-terminal proteinase enhancer; procollagen, type 1, COOH-terminal proteinase enhancer;
Cat.#:PCOLCE-838HTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCOLCE, T7-tagged
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Cat.#:PCOLCE-1580HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCOLCE, His-tagged
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Cat.#:PCOLCE-30795THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human PCOLCE
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Cat.#:PCOLCE-372HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human PCOLCE
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Cat.#:PCOLCE-6802HTag:His/S
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human PCOLCE protein, His & S-tagged
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Cat.#:Pcolce-6803MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Pcolce protein, His-tagged
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Cat.#:PCOLCE-4304RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat PCOLCE Protein
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Cat.#:PCOLCE-3375HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human PCOLCE 293 Cell Lysate
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Involved Pathway

Pcolce involved in several pathways and played different roles in them. We selected most pathways Pcolce participated on our site, such as Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Pcolce were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Assembly of collagen fibrils and other multimeric structures
COL8A2; BMP1B; LOX; PLEC; TLL2; CTSS; MMP13; TLL1; COL5A3A; COL6A1
Collagen biosynthesis and modifying enzymes
P3H2; COL5A3B; COL11A1B; COL17A1A; COL28A1A; COL19A1; LEPREL1; COL16A1; COL4A3; COL6A3
Collagen formation
LOX; COL8A1A; COL25A1; COL9A1; ADAMTS3; PCOLCEB; COL5A3A; COL8A1; COL11A1B; COL15A1B
Crosslinking of collagen fibrils
LOX; TLL1; BMP1A; LOXL4; TLL2; BMP1; BMP1B; LOXL1; ABHD1; LOXL2
Extracellular matrix organization
COL4A3; MGC174857; DMP1; LOXL4; PCOLCE2; COL15A1B; LEPRE1; LOXL2; MFAP4; COL10A1A

Protein Function

Pcolce has several biochemical functions, for example, collagen binding, heparin binding, peptidase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Pcolce itself. We selected most functions Pcolce had, and list some proteins which have the same functions with Pcolce. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein DDR1; SRGN; Pdgfa&Pdgfb; MMP9; SMAD4; RELL2; SMAD7; C1QTNF1; Itga10&Itgb1; ITGA3
Function heparin binding
Related Protein REG4; SLIT2; LRPAP1; SLIT3; FMOD; FGFR1A; CCL7; SELL; VEGFA; VEGFAA
Function peptidase activator activity
Related Protein MMP25; PSME4B; APP; MMP14; PSME4; CLPX; CAV1; PCOLCE2; FN1; FBLN1
Function protein binding
Related Protein RAB3C; IL7R; URM1; SIRT7; TRAPPC4; KDR; TFIP11; TTC37; AGR2; ADM

Interacting Protein

Pcolce has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Pcolce here. Most of them are supplied by our site. Hope this information will be useful for your research of Pcolce.
COL18A1; lm-111_human_complex; collagen_vi_human; APP; THBS1; hyaluronan; chondroitin_sulfate; dermatan_sulfate; heparin; heparan_sulfate; collagen_iv_human-3_complex

Pcolce Related Articles

Raz, V; Sterrenburg, E; et al. Nuclear entrapment and extracellular depletion of PCOLCE is associated with muscle degeneration in oculopharyngeal muscular dystrophy. BMC NEUROLOGY 13:-(2013).
Goldsmith, EC; Bradshaw, AD; et al. Cellular Mechanisms of Tissue Fibrosis. 2. Contributory pathways leading to myocardial fibrosis: moving beyond collagen expression. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 304:C393-C402(2013).