rab7a
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  • Official Full Name
  • RAB7A, member RAS oncogene family
  • Background
  • RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport.;Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family;member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded;protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly;conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies.
  • Synonyms
  • RAB7A; RAB7A, member RAS oncogene family; RAB7, RAB7, member RAS oncogene family; ras-related protein Rab-7a; Ras-associated protein RAB7; RAB7, member RAS oncogene family; RAB7; PRO2706; FLJ20819
Cat.#:RAB7A-194HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAB7A, His-tagged
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Cat.#:Rab7a-1129RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Rab7a Protein, His-tagged
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Cat.#:RAB7A-4898RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAB7A Protein
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Cat.#:RAB7A-1117DTag:N/A
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog RAB7A, Member RAS Oncogene Family
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Cat.#:RAB7A-1118DTag:His/GST
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog RAB7A, Member RAS Oncogene Family, GST-His
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Cat.#:RAB7A-2583HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAB7A 293 Cell Lysate
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Involved Pathway

RAB7A involved in several pathways and played different roles in them. We selected most pathways RAB7A participated on our site, such as Endocytosis, Phagosome, Salmonella infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAB7A were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Endocytosis
RAB11FIP3; SH3GLB1A; HSC70; SH3GLB1B; KDR; SNX3; GIT2A; NEDD4L; ITCHA; HRASB
Phagosome
HLA-DRB3; HLA-E; BF1; ABCB3L1; CTSLA; CALR; TFRC; C3A.3; DYNC1LI1; HLA-DQA2
Salmonella infection
MAPK8A; CCL3L3; TLR4BB; KLC1B; KLC1A; DYNC2H1; KLC2; CDC42L; MAPK14B; IFNGR1
Amoebiasis
SERPINB2; CTSG; COL4A5; COL1A1; LAMA3; HSPB1; COL4A6; RAB5C; IL12B; LAMB1
Tuberculosis
AKT2; PMAP-36; ATP6V0D1; PPP3R2; CALM2; MAPK11; Il23a; HLA-DMA; SRC; ATP6V0A4

Protein Function

RAB7A has several biochemical functions, for example, GDP binding, GTP binding, GTPase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAB7A itself. We selected most functions RAB7A had, and list some proteins which have the same functions with RAB7A. You can find most of the proteins on our site.
Function
Related Protein
Function GDP binding
Related Protein RAB27B; PCK1; SRP54B; RAB27A; RHOA; RAB7L1; MIEF1; RAB5C; RAP1B; RAB8B
Function GTP binding
Related Protein ARL13B; RHOH; DIRAS3; TUBG2; RAB33A; RHOF; RAP2A; EEF2A.1; TUBA3E; EEF2A.2
Function GTPase activity
Related Protein TUBA8L4; RAB25A; RAB10; LRRK2; MFN1; RABL5; RAB38; RAB14L; DNM1L; ARL4D
Function Rac GTPase binding
Related Protein RALBP1; PAK7; RCC2; ARHGAP4; OCRL; PAK1; EPS8; ITPKA; ARFIP2; SRGAP2B
Function protein binding
Related Protein AP1M1; PPIC; ACTR1B; KPNA4; IGHM; HBA1; ST6GAL1; INO80E; VPS29; ZMYND11

Interacting Protein

RAB7A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAB7A here. Most of them are supplied by our site. Hope this information will be useful for your research of RAB7A.
RILP; 1-phosphatidyl-1d-myo-inositol 3,5-bisphosphate; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; DNM2; SH3KBP1; EIF1B; MCC; MPG; HLA-B; VHL; GABARAPL2; IKBKE; ATG5; PRKAB1; TRAF6

RAB7A Related Articles

Day, PM; Thompson, CD; et al. Identification of a Role for the trans-Golgi Network in Human Papillomavirus 16 Pseudovirus Infection. JOURNAL OF VIROLOGY 87:3862-3870(2013).
Osinska, M; Wiejak, J; et al. Distinct expression, localization and function of two Rab7 proteins encoded by paralogous genes in a free-living model eukaryote. ACTA BIOCHIMICA POLONICA 58:597-607(2011).