ramp1
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  • Official Full Name
  • receptor (G protein-coupled) activity modifying protein 1
  • Background
  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP1) protein, CRLR functions as a CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.
  • Synonyms
  • RAMP1; receptor (G protein-coupled) activity modifying protein 1; receptor (calcitonin) activity modifying protein 1 , receptor activity modifying protein 1; receptor activity-modifying protein 1; calcitonin receptor like receptor activity modifying protein 1; CRLR activity modifying protein 1; receptor (G protein coupled) activity modifying protein 1; receptor activity modifying protein 1 [Precursor]; CRLR activity-modifying protein 1; receptor activity modifying protein 1; receptor (calcitonin) activity modifying protein 1; calcitonin receptor-like receptor activity modifying protein 1; calcitonin-receptor-like receptor activity-modifying protein 1
Cat.#:RAMP1-421HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human receptor (G protein-coupled) activity modifying protein 1, His-tagged
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Cat.#:RAMP1-5022HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAMP1, His-tagged
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Cat.#:RAMP1-742HTag:His
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human RAMP1
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Cat.#:RAMP1-4919RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAMP1 Protein
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Cat.#:RAMP1-2537HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAMP1 293 Cell Lysate
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Involved Pathway

RAMP1 involved in several pathways and played different roles in them. We selected most pathways RAMP1 participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), Endothelin, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcitonin-like ligand receptors
CALCB; RAMP3; ADM; CALCRL; ADM2A; RAMP2; RAMP1; ADM2; CALCA
Class B/2 (Secretin family receptors)
CRH; PTH; ADCYAP1R1; GNB5B; GNB3B; EMR3; SETD6; ADM2; PTHRP2; GNB3A
Endothelin
CALCA; RAMP1; MYL1; EDNRB; ECE1; CALCRL; EDNRA; CNN1; EDN1
G alpha (s) signalling events
GCGB; CALCB; RXFP2B; PTH; RLN3A; RAMP3; ADRB3; RLN2; PDE10A; PTH2
GPCR downstream signaling
RGS4; EDNRAB; FGD2; ADORA2A; ADORA1; S1PR1; RHOL; SSTR4; NMBB; OXGR1A.2
GPCR ligand binding
ADCYAP1R1; GCGA; RGS1; NPFF; CRHR1; TAC2; NMBA; OXGR1; ADCYAP1B; RLN2
Myometrial Relaxation and Contraction Pathways
RAMP1; ATF5; CRHR1; RGS16; RGS4; MAFF; PKIG; CNN1; CNN2; IGFBP4
Signal Transduction
NRP2A; DHRS4; NOXA1; RGS14; CCL19A.2; MYO9B; APOA4A; USP2; RHOT1B; CRABP1

Protein Function

RAMP1 has several biochemical functions, for example, calcitonin receptor activity, calcitonin receptor binding, coreceptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP1 itself. We selected most functions RAMP1 had, and list some proteins which have the same functions with RAMP1. You can find most of the proteins on our site.
Function
Related Protein
Function calcitonin receptor activity
Related Protein CALCRLA; CALCR; CALCRL; RAMP1
Function calcitonin receptor binding
Related Protein RAMP1; CALCA
Function coreceptor activity
Related Protein CXCR7; RGMD; RGMB; CXCR7B; RAMP3; TGFBR3; IGSF1; CD8A; CD28; NRP1
Function protein binding
Related Protein TFRC; MAST2; WDR4; F7; CHP; MLF2; RCN1; KCTD14; WDR20; C1orf35
Function protein transporter activity
Related Protein EIF4ENIF1; AP1S3B; RAMP3; KPNA5; AP1G2; KPNA3; IPO9; KPNB1; TNPO2; VPS26B
Function receptor activity
Related Protein PAQR5B; TNFRSF9; Siglece; IL18R1; CD33; PROCR; NRP2; STRA6; TACSTD2; ANTXR2B

Interacting Protein

RAMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP1.
CALCRL

RAMP1 Related Articles

Desai, AJ; Roberts, DJ; et al. Role of Receptor Activity Modifying Protein 1 in Function of the Calcium Sensing Receptor in the Human TT Thyroid Carcinoma Cell Line. PLOS ONE 9:-(2014).
Seiler, K; Nusser, JI; et al. Changes in calcitonin gene-related peptide (CGRP) receptor component and nitric oxide receptor (sGC) immunoreactivity in rat trigeminal ganglion following glyceroltrinitrate pretreatment. JOURNAL OF HEADACHE AND PAIN 14:-(2013).