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RAMP2

Official Full Name

receptor (G protein-coupled) activity modifying protein 2
Overview

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
Synonyms

RAMP2; receptor (G protein-coupled) activity modifying protein 2; receptor (calcitonin) activity modifying protein 2 , receptor activity modifying protein 2; receptor activity-modifying protein 2; Calcitonin receptor like receptor activity modifying protein 2; CRLR activity modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; Receptor (calcitonin) activity modifying protein 2; Receptor activity modifying protein 2; Receptor activity modifying protein 2 isoform; RP23-281C18.6; CRLR activity-modifying protein 2; receptor-activity-modifying protein 2; calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Homo sapiens (Human)
Human
Mouse
Rat
Zebrafish

Source

E.coli
E.coli expression system
HEK293
Mammalian Cell
Mammalian cells

Tag

C
His
GST
His (Fc)
Avi
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	RAMP2-2171H	Recombinant Human RAMP2, GST-tagged	E.coli	GST	N-term-148aa	$319 / 25ug
Human	RAMP2-2536HCL	Recombinant Human RAMP2 293 Cell Lysate	HEK293	N/A		Inquiry
Human	RAMP2-2010H	Recombinant Human RAMP2 Protein, His&GST-tagged	E.coli	N-His&GST	Gln43-Val145	Inquiry
Mouse	Ramp2-6783M	Recombinant Mouse Ramp2 Protein (Ser45-Val159), C-His tagged	Mammalian cells	C-His	Ser45-Val159	Inquiry
Mouse	Ramp2-6782M	Recombinant Mouse Ramp2 Protein (Ser45-Val159), C-His tagged	E.coli	C-His	Ser45-Val159	Inquiry
Rat	RAMP2-4920R	Recombinant Rat RAMP2 Protein	Mammalian Cell	His		Inquiry
Rat	RAMP2-4579R	Recombinant Rat RAMP2 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	RAMP2-4579R-B	Recombinant Rat RAMP2 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Homo sapiens (Human)	RFL7189HF	Recombinant Full Length Human Receptor Activity-Modifying Protein 2(Ramp2) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (43-175)	Inquiry
Zebrafish	RAMP2-6403Z	Recombinant Zebrafish RAMP2	Mammalian Cell	His		Inquiry
Chicken	RAMP2-3751C	Recombinant Chicken RAMP2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
RAMP2 Related Articles

RAMP2 involved in several pathways and played different roles in them. We selected most pathways RAMP2 participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Calcitonin-like ligand receptors	ADM;RAMP2;ADM2;CALCA;RAMP1;CALCB;ADM2A;RAMP3;CALCRL
Class B/2 (Secretin family receptors)	GHRH;ADCYAP1;CALCB;SCT;ADM2A;ADCYAP1R1;CRH;GNB5A;RAMP3
G alpha (s) signalling events	PTH2;CGA;ADM2A;RAMP1;NPSR1;VIP;RLN2;CALCRL;ADCYAP1
GPCR downstream signaling	CCR3;PTHLHA;ADCYAP1R1;RGS20;CALCRL;RGS4;OR10A5;OPN1MW2;DRD2
GPCR ligand binding	RXFP2;CCR3;CGA;CCBP2;PENKA;FPR-RS4;GPR37L1;EDN3;CXCL11.8
Myometrial Relaxation and Contraction Pathways	RGS17;CORIN;RAMP2;ATF5;RAMP1;GPR182;RAMP3;RGS16;CRCP
Signal Transduction	PTH;NET1;RGS18;GPRC6A;RCA2.1;NMT1A;GPR132B;DTX2;AKAP13
Signaling by GPCR	RGS20;OPN4A;OR56A1;RGS4;SCT;CCK;CCL35.2;VIP2;ARHGAP4

RAMP2 has several biochemical functions, for example, coreceptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP2 itself. We selected most functions RAMP2 had, and list some proteins which have the same functions with RAMP2. You can find most of the proteins on our site.

Function	Related Protein
coreceptor activity	CXCR7;CD8A;RGMD;CD80;LRP5;NRP1;IGSF1;RAMP2;LY96
protein binding	SLC22A6;GAPDHS;RHPN1;NOTCH1;SNAP47;CRB1;SRSF7;PAX6;SCFD1
protein transporter activity	XPO1;IPO9;DPY19L2;AP2B1;KPNA2;ITGB1BP1;CHMP7;XPO5;DSCR3

RAMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP2.

CALCRL

Berenguer-Daize, C; Boudouresque, F; et al. Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice. CLINICAL CANCER RESEARCH 19:6138-6150(2013).

Iesato, Y; Toriyama, Y; et al. Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 182:2380-2390(2013).