ramp2
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  • Official Full Name
  • receptor (G protein-coupled) activity modifying protein 2
  • Background
  • The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
  • Synonyms
  • RAMP2; receptor (G protein-coupled) activity modifying protein 2; receptor (calcitonin) activity modifying protein 2 , receptor activity modifying protein 2; receptor activity-modifying protein 2; Calcitonin receptor like receptor activity modifying protein 2; CRLR activity modifying protein 2; OTTMUSP00000002615; OTTMUSP00000037624; Receptor (calcitonin) activity modifying protein 2; Receptor activity modifying protein 2; Receptor activity modifying protein 2 isoform; RP23-281C18.6; CRLR activity-modifying protein 2; receptor-activity-modifying protein 2; calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2
Cat.#:RAMP2-2171HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RAMP2, GST-tagged
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Cat.#:RAMP2-4920RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RAMP2 Protein
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Cat.#:RAMP2-3751CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RAMP2
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Cat.#:RAMP2-6403ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RAMP2
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Cat.#:RAMP2-2536HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RAMP2 293 Cell Lysate
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Involved Pathway

RAMP2 involved in several pathways and played different roles in them. We selected most pathways RAMP2 participated on our site, such as Calcitonin-like ligand receptors, Class B/2 (Secretin family receptors), G alpha (s) signalling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with RAMP2 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Calcitonin-like ligand receptors
RAMP2; CALCRL; ADM2A; RAMP1; ADM; ADM2; RAMP3; CALCB; CALCA
Class B/2 (Secretin family receptors)
SETD6; GNB5B; PTH; ADCYAP1B; RAMP3; GHRH; FZD10; CRHR2; PTHRP2; PTHLH
G alpha (s) signalling events
ADM2; PTH; CRH; RLN3; GCGA; RXFP2; ADCYAP1R1; PTHLH; POMCB; PTHLHA
GPCR downstream signaling
EDNRAB; HEBP1; CRHB; ADRA2B; FGD4A; TAS2R3; EDN1; RLN3A; APLNR; GHRH
GPCR ligand binding
ADORA2B; NPB; AGTR2; CXCL13; FPR-RS6; SST; CHRM5; ANXA1; TAC3; EDNRAB
Myometrial Relaxation and Contraction Pathways
IGFBP5; CRCP; IGFBP2; PKIB; RXFP2; RAMP3; GUCA2A; GPR182; CNN1; RGS17
Signal Transduction
AKR1C6; OR52B4; RGR; STRA6; WLS; TAS2R13; CCL19A.2; PYYA; FMNL2; OR4D2
Signaling by GPCR
RGR; RCA2.1; KISS1; PROKR1; CALCB; OPN5; RGS7; PTHLHA; RGS18; APLN

Protein Function

RAMP2 has several biochemical functions, for example, coreceptor activity, protein binding, protein transporter activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RAMP2 itself. We selected most functions RAMP2 had, and list some proteins which have the same functions with RAMP2. You can find most of the proteins on our site.
Function
Related Protein
Function coreceptor activity
Related Protein ACKR3B; IGSF1; LRP5; RAMP2; CD8B; LY96; TGFBR3; RGMD; CD86; CD8A
Function protein binding
Related Protein TMEM8A; MRAP; PPP2CA; Unc5b; MSR1; TEX13A; FNBP4; CCT4; NAA10; ADCY6
Function protein transporter activity
Related Protein TMCO6; MLC1; CALCR; IPO13; COG3; AP3S2; RAP1A; VPS26B; FRAG1; VPS35

Interacting Protein

RAMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RAMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RAMP2.
CALCRL

RAMP2 Related Articles

Berenguer-Daize, C; Boudouresque, F; et al. Adrenomedullin Blockade Suppresses Growth of Human Hormone-Independent Prostate Tumor Xenograft in Mice. CLINICAL CANCER RESEARCH 19:6138-6150(2013).
Iesato, Y; Toriyama, Y; et al. Adrenomedullin-RAMP2 System Is Crucially Involved in Retinal Angiogenesis. AMERICAN JOURNAL OF PATHOLOGY 182:2380-2390(2013).