Recombinant Human RAMP2 Protein, His&GST-tagged

• Cat.No.: RAMP2-2010H
• Product Overview: Recombinant Human RAMP2 Protein (Gln43-Val145) with N-His&GST tag was expressed in E. coli.

Specification

• Description: The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.
• Source: E. coli
• Species: Human
• Tag: N-His&GST
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 41.8 kDa
  Accurate Molecular Mass: 43 kDa
• Protein length: Gln43-Val145
• Purity: > 97%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 100mM NaHCO3, 500mM NaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 100mM NaHCO3, 500mM NaCl (pH8.3) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: RAMP2 receptor (G protein-coupled) activity modifying protein 2 [ Homo sapiens (human) ]
• Official Symbol: RAMP2
• Synonyms: RAMP2; receptor (G protein-coupled) activity modifying protein 2; receptor (calcitonin) activity modifying protein 2, receptor activity modifying protein 2; receptor activity-modifying protein 2; CRLR activity-modifying protein 2; receptor activity modifying protein 2; receptor-activity-modifying protein 2; receptor (calcitonin) activity modifying protein 2; calcitonin receptor-like receptor activity modifying protein 2; calcitonin-receptor-like receptor activity-modifying protein 2
• Gene ID: 10266
• mRNA Refseq: NM_005854
• Protein Refseq: NP_005845
• MIM: 605154
• UniProt ID: O60895