RCOR1 Protein, REST corepressor 1

RCOR1

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RCOR1

Official Full Name REST corepressor 1
Background This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]
Synonyms RCOR1; REST corepressor 1; RCOR; COREST;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human RCOR1-1852H Recombinant Human REST Corepressor 1, His-tagged E.coli His
    Human RCOR1-71H Recombinant Human RCOR1 protein, His-tagged E.coli His
    Human RCOR1-73H Recombinant Human RCOR1 protein, GST-tagged Wheat Germ GST
    Mouse RCOR1-14038M Recombinant Mouse RCOR1 Protein Mammalian Cell His
    Zebrafish RCOR1-4984Z Recombinant Zebrafish RCOR1 Mammalian Cell His

    RCOR1 involved in several pathways and played different roles in them. We selected most pathways RCOR1 participated on our site, such as Huntingtons disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with RCOR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Huntingtons disease SDHC; COX4I1; PLCB1; TFAM; CASP8; COX6B1; DNALC1; SP1; GRM5; NDUFA4L2

    RCOR1 has several biochemical functions, for example, DNA binding, enzyme binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RCOR1 itself. We selected most functions RCOR1 had, and list some proteins which have the same functions with RCOR1. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SALL3; SIM1; KAT6A; POLR3B; SMAD3B; NFE2L2B; ZFP511; HIST1H2AK; ZNF222; PALB2
    enzyme binding KIAA1967; POR; PCCA; NLRP1; NFKBIA; RFC5; HYAL2; CYP2A6; SCARB2; CYP3A4
    protein binding ARIH2; SSTR3; MAGI2; HIST1H2AL; ECT2; NOC2L; JUB; TEKT5; CHD4; TGFBR1
    transcription regulatory region DNA binding HNF4A; ATMIN; EGR2; ASH2L; TP53; ETV5; H2AFY; SALL1A; TCF7L1A; SP1
    transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding TFAP2A; HSF1; ZFPM2; NFIL3-6; BCL11A; NFIL3-4; IFI203; PYDC3; SNAI1; TBX15

    RCOR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RCOR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RCOR1.

    Nr4a2; Gfi1b; inos_mouse_gene; tnfa_mouse_gene; Hdac1; Hdac2; Nanog

    Pilotto, S; Speranzini, V; et al. Interplay among nucleosomal DNA, histone tails, and corepressor CoREST underlies LSD1-mediated H3 demethylation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:2752-2757(2015).
    Meier, K; Brehm, A; et al. Chromatin regulation: How complex does it get?. EPIGENETICS 9:1485-1495(2014).

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