rgma
Share
  • Official Full Name
  • repulsive guidance molecule family member A
  • Background
  • Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
  • Synonyms
  • RGMA; repulsive guidance molecule family member A; BC059072; C230063O06; repulsive guidance molecule A; RGM domain family, member A;
Cat.#:RGMA-2748HTag:His|Myc
Source (Host):BaculovirusSpecies:Human
Product nameRecombinant Human RGMA Protein (169-424 aa), His-MBP-tagged
+Inquiry
Cat.#:RGMA-1043HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RGMA Protein, MYC/DDK-tagged
+Inquiry
Cat.#:RGMA-857RTag:His
Source (Host):HEK293Species:Rhesus monkey
Product nameRecombinant Rhesus monkey RGMA Protein, His-tagged
+Inquiry
Cat.#:RGMA-2271HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RGMA, His-tagged
+Inquiry
Cat.#:RGMA-2416HTag:Flag
Source (Host):HEK293Species:Human
Product nameRecombinant Human RGM Domain Family, Member A, FLAG-tagged
+Inquiry
Cat.#:RGMA-7011HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human RGMA, His tagged
+Inquiry
Cat.#:RGMA-14126MTag:His
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Rgma protein, His-tagged
+Inquiry
Cat.#:Rgma-2417MTag:Flag
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse RGM Domain Family, Member A, FLAG-tagged
+Inquiry
Cat.#:RGMA-856CTag:His
Source (Host):Mammalian CellsSpecies:Cynomolgus Monkey
Product nameRecombinant Cynomolgus RGMA Protein, His-tagged
+Inquiry
Cat.#:RGMA-3868RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RGMA Protein, His-tagged
+Inquiry
Cat.#:RGMA-6106CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RGMA
+Inquiry
Cat.#:RGMA-4088ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RGMA
+Inquiry
Cat.#:RGMA-1697HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human RGMA cell lysate
+Inquiry

Involved Pathway

RGMA involved in several pathways and played different roles in them. We selected most pathways RGMA participated on our site, such as Axon guidance, BMP receptor signaling, Developmental Biology, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGMA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
AP2A1; DNM1; RASA1; CAP2; PAK7; PLXND1; FES; SCN4A; ROCK1; ITGB1B.1
BMP receptor signaling
CTDSP2; HFE2; RGMB; GREM1; CTDSP1; CALML4; NOG; CTDSPL; SKI; RGMA
Developmental Biology
PAK4; ARPC1A; MED21; EPHA2; BNIP2; TCF4; RNF8; DUSP6; EVL; COL4A4
Netrin-1 signaling
SIAH2; RGMB; TRPC4; PITPNA; EZRA; NTN1B; HFE2; UNC5D; NTN1A; TRPC5
Spinal Cord Injury
LGALS3; GDNF; OMG; AIF1; GAP43; PTPRZ1; MBP; KLK8; TNFSF13B; RGMA

Protein Function

RGMA has several biochemical functions, for example, coreceptor activity, glycoprotein binding, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RGMA itself. We selected most functions RGMA had, and list some proteins which have the same functions with RGMA. You can find most of the proteins on our site.
Function
Related Protein
Function coreceptor activity
Related Protein CXCR7; ACKR3B; CXCR4; CXCR7B; ACVR2A; RGMA; TMIGD2; CCR8; HFE2; CD8B
Function glycoprotein binding
Related Protein SELP; Serpina1c; F7; ERBB2; FGFR1; FBXO17; DNAJC5; BBC3; Serpina1b; FBXO27
Function protein binding
Related Protein ZNF266; HNF1B; FAM114A1; MYLK; FAM81B; RAD50; LSM8; MAP1B; CD63; RASGRP3
Function transferrin receptor binding
Related Protein SNX4; CD81; RGMA; SNX1; HFE; HFE2; TF; Trf; SNX2

Interacting Protein

RGMA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGMA here. Most of them are supplied by our site. Hope this information will be useful for your research of RGMA.
TERF2IP; SGSM2; PPP1R16A; BDP1; NCOR2; TCEB2; SAMD4B; NBEAL1; SPICE1; PPHLN1; ANO3; HIPK2; TXNIP; CLK4