ripk2
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  • Official Full Name
  • receptor-interacting serine-threonine kinase 2
  • Background
  • This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein contains a C-terminal caspase activation and recruitment domain (CARD), and is a component of signaling complexes in both the innate and adaptive immune pathways. It is a potent activator of NF-kappaB and inducer of apoptosis in response to various stimuli. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RIPK2; receptor-interacting serine-threonine kinase 2; CCK; RICK; RIP2; CARD3; GIG30; CARDIAK; receptor-interacting serine/threonine-protein kinase 2; RIP-2; CARD-carrying kinase; growth-inhibiting gene 30; tyrosine-protein kinase RIPK2; receptor-interacting protein 2; CARD-containing IL-1 beta ICE-kinase; CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase; receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase;
Cat.#:RIPK2-5564HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RIPK2 Protein, His-tagged
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Cat.#:RIPK2-5565HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human RIPK2, GST-tagged
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Cat.#:RIPK2-418HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK2, GST-tagged, Active
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Cat.#:RIPK2-711HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK2, GST-His
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Cat.#:RIPK2-29983THTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RIPK2
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Cat.#:RIPK2-419HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RIPK2, His-tagged, Active
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Cat.#:RIPK2-532HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RIPK2, MYC/DDK-tagged
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Cat.#:RIPK2-932HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RIPK2 protein, His-tagged
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Cat.#:RIPK2-14244MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RIPK2 Protein
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Cat.#:Ripk2-1795MTag:His|T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ripk2 protein, His & T7-tagged
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Cat.#:Ripk2-1796RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ripk2 protein, His & T7-tagged
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Cat.#:RIPK2-2632CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RIPK2
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Cat.#:RIPK2-9761ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RIPK2
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Cat.#:RIPK2-1479HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RIPK2 (Active), GST-tagged
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Cat.#:RIPK2-2333HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RIPK2 293 Cell Lysate
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Cat.#:Kit-1623Tag:N/A
Source (Host):Species:
Product nameRIPK2 Kinase Binding Assay Kit
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Involved Pathway

RIPK2 involved in several pathways and played different roles in them. We selected most pathways RIPK2 participated on our site, such as NOD-like receptor signaling pathway, Neurotrophin signaling pathway, Shigellosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
NOD-like receptor signaling pathway
IL8L1; MAPK12A; MAPK8A; NFKBIB; MAPK1; IL18; NAIP1; CCL5; CASP1; CXCL8B.3
Neurotrophin signaling pathway
PLCG1; MAP2K1; CAMK2A; PIK3CD; IRAK2; NTRK2; MATK; RHOA; MAPKAPK2; MAPK3
Shigellosis
ELMO3; VCL; ACTB; WAS; RELA; ELMO2; MAPK8; RIPK2; ABL1; MAPK12
Tuberculosis
FCGR2A; HLA-DOB; IL23; IFNA2; BCL2; MAPK9; RFXANK; IL1B; IL1A; CAMK2A

Protein Function

RIPK2 has several biochemical functions, for example, ATP binding, CARD domain binding, LIM domain binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK2 itself. We selected most functions RIPK2 had, and list some proteins which have the same functions with RIPK2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein ATP1A3B; NLRP9B; PRPF4B; TNIKB; DNA2; ADRBK2; PRKY; DCLK1; BCKDK; ORC1L
Function CARD domain binding
Related Protein MAVS; CARD9; C9orf89; RIPK2; CARD14; NOD1; CARD11
Function LIM domain binding
Related Protein LDB2A; LDB2; RPH3AL; LDB1; RIPK2; CSRP2BP; LDB2B; ACTN2; LDB1B; LDB1A
Function non-membrane spanning protein tyrosine kinase activity
Related Protein HCK; BMX; TNK1; PTK2; SRC; PTK2AB; JAK1; PTK2B; PTK6; BLK
Function protein binding
Related Protein TRIM23; NEU4; C1orf182; MASP2; PAG1; WDR4; SH3BP1; LRRC8C; ARAP1; ACY3
Function protein homodimerization activity
Related Protein USF2; SRF; LMLN; CRYBA1; GRHPR; NADK2; COMMD1; HNF4A; RAB11FIP4A; EXT1
Function protein serine/threonine kinase activity
Related Protein MYO3A; TSSK3; MAP4K6; STK38L; TAOK1; TSSK4; RPS6KB1B; MAP2K7; PHKG1B; CAMK2G1
Function receptor binding
Related Protein PLA2G1B; GRIN2A; SLC9A3R1; DAO1; NRXN1; HFE2; ANG; EDA; RSPO3; PVRL1B
Function signal transducer activity
Related Protein TAAR12G; OPN4A; MRGPRG; GPR124; GRM6B; HTR1D; TAS2R113; IL13RA2; OLFR488; TAS2R110

Interacting Protein

RIPK2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK2.
XIAP; NOD2; TRAF3; BIRC3; BIRC2; TRAF2