ripk3
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  • Official Full Name
  • receptor-interacting serine-threonine kinase 3
  • Background
  • Receptor-interacting protein 3 (RIP3) contains a N-terminal kinase domain and interacts with RIP. The binding of RIP to RIP3 causes the RIP3/RIP complex to be shuttled into the tumor necrosis factor receptor-1 signaling cascade. RIP3 is known to be a very effective apoptosis inducer. Two novel splice variants of RIP3 have been discovered, RIP3 beta and RIP3 gamma, that have shown to decrease apoptosis related to full length RIP3. RIP3 gamma has been shown to be significantly up-regulated in colon and lung cancers and may play a role in tumorigenesis.
  • Synonyms
  • RIPK3; receptor-interacting serine-threonine kinase 3; receptor-interacting serine/threonine-protein kinase 3; RIP3; RIP-3; RIP-like protein kinase 3; receptor interacting protein 3; receptor-interacting protein 3
Cat.#:RIPK3-1723MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse RIPK3 Protein (1-486 aa), His-tagged
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Cat.#:RIPK3-1756HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human RIPK3 Protein (1-518 aa), His-tagged
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Cat.#:RIPK3-2313HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RIPK3, GST-tagged
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Cat.#:RIPK3-2758HTag:GST
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RIPK3, GST-tagged, Active
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Cat.#:RIPK3-2899HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RIPK3, GST-tagged
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Cat.#:RIPK3-29985THTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RIPK3
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Cat.#:RIPK3-894HTag:GST
Source (Host):Sf9 cellsSpecies:Human
Product nameRecombinant Human RIPK3 Protein, GST-tagged
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Cat.#:Ripk3-1262MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ripk3 protein, His-tagged
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Cat.#:Ripk3-1263RTag:His|T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Ripk3 protein, His & T7-tagged
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Cat.#:RIPK3-5053RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RIPK3 Protein
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Cat.#:RIPK3-2332HCLTag:N/A
Source (Host):Species:Human
Product nameRecombinant Human RIPK3 293 Cell Lysate
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Involved Pathway

RIPK3 involved in several pathways and played different roles in them. We selected most pathways RIPK3 participated on our site, such as Activated TLR4 signalling, Cytosolic DNA-sensing pathway, Cytosolic sensors of pathogen-associated DNA, which may be useful for your reference. Also, other proteins which involved in the same pathway with RIPK3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activated TLR4 signalling
MAPKAPK2B; MAP3K8; ATF2; IRAK3; PELI1; PELI3; DUSP3; S100A12; TICAM1; TANK
Cytosolic DNA-sensing pathway
IFNA17; CCL5; TBK1; IFNA12; POLR3GL; IFNA2; POLR2H; IFNA7; RIPK1; IFNA6
Cytosolic sensors of pathogen-associated DNA
RIPK3; POLR3H; POLR3C; NLRP4C; LRRFIP1; NLRP4E; APPA; TREX1; DHX9; AGER
IKK complex recruitment mediated by RIP1
RIPK3
Immune System
DYNC1I1; TRIM2; TANK; KPNA4; ASB3; RNF6; UBR1; BTR30; POLR3C; SIGLEC14
Innate Immune System
BTR18; BTR02; RCA2.1; CD300LB; TREX1; PANX1; NCKIPSD; RNF135; BTR16; DEFB1
MyD88-independent TLR3/TLR4 cascade
RIPK3; TANK
Programmed Cell Death
DSG2; MLKL; STK24B; GAS2; DSG3; DSP; DSG1; PKP1; VIML; SATB1

Protein Function

RIPK3 has several biochemical functions, for example, ATP binding, NF-kappaB-inducing kinase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RIPK3 itself. We selected most functions RIPK3 had, and list some proteins which have the same functions with RIPK3. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein IPPK; VPS4A; ACACB; CARNS1; ALDH18A1; UBE2L3B; KATNAL1; ABCC3; RPS6KA4; STK24B
Function NF-kappaB-inducing kinase activity
Related Protein PPP4C; RIPK3; IRAK1; IKBKE; ALPK2; MAP3K14; ALK
Function identical protein binding
Related Protein CHEK2; VEGFA; DAPK2; SERPINA1A; TYROBP; ITGB3; CCT7; PITX2; SHMT2; GPSM2
Function protein binding
Related Protein IQSEC3; NOTCH2NL; YAF2; EIF4A3; CGGBP1; DICER1; UBASH3B; CSNK2B; G3BP2; B3GAT3
Function protein complex binding
Related Protein PPP1R9B; C8A; SLC25A3; ERCC6; NRAS; CRTAP; RELA; AP2A1; SHANK1; DRD1A
Function protein kinase activity
Related Protein RIPK4; SOX9; CAMK1DB; PTK7A; MAP3K2; TNK2B; PIK3C3; JAK2; PRKCBA; PANK1A
Function protein serine/threonine kinase activity
Related Protein BMP2K; RPS6KA2; MAP4K1; BCR; MAP4K4; STK17A; MAP4K2; SGK3; IRAK3; ACVR1BA
Function transcription coactivator activity
Related Protein ATF6; RXRA; THRAP3; MAK; HCFC1; NPAT; JUPA; CARM1; RXRB; NCOA1

Interacting Protein

RIPK3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RIPK3 here. Most of them are supplied by our site. Hope this information will be useful for your research of RIPK3.
RIPK1