rps6
Share
  • Official Full Name
  • ribosomal protein S6
  • Background
  • Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a cytoplasmic ribosomal protein that is a component of the 40S subunit. The protein belongs to the S6E family of ribosomal proteins. It is the major substrate of protein kinases in the ribosome, with subsets of five C-terminal serine residues phosphorylated by different protein kinases. Phosphorylation is induced by a wide range of stimuli, including growth factors, tumor-promoting agents, and mitogens. Dephosphorylation occurs at growth arrest. The protein may contribute to the control of cell growth and proliferation through the selective translation of particular classes of mRNA. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
  • Synonyms
  • RPS6; ribosomal protein S6; S6; 40S ribosomal protein S6; phosphoprotein NP33;
Cat.#:RPS6-171Tag:GST
Source (Host):Insect cellsSpecies:
Product nameRecombinant RPS6 Protein, GST-tagged
+Inquiry
Cat.#:RPS6-30769THTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6
+Inquiry
Cat.#:RPS6-307HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RPS6, GST-tagged
+Inquiry
Cat.#:RPS6-14492MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS6 Protein
+Inquiry
Cat.#:RPS6-5171RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat RPS6 Protein
+Inquiry
Cat.#:RPS6-6778CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RPS6
+Inquiry
Cat.#:RPS6-1072ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RPS6
+Inquiry
Cat.#:RPS6-567HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human RPS6 lysate
+Inquiry

Involved Pathway

RPS6 involved in several pathways and played different roles in them. We selected most pathways RPS6 participated on our site, such as Ribosome, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Ribosome
RPL8; MRPL30; RPS14; RPL3L; RPL9; RPL39; RPS4X; RPS26L; RPL19; RPS15
HIF- signaling pathway
PIK3CG; PLCG2; MAPK3; PIK3CB; IFNGR1; ERBB2; PIK3R3; PIK3R2; NOX3; IFNGR2
mTOR signaling pathway
RICTOR; RPS6KB1; INS1; PIK3CG; DDIT4; AKT2; EIF4E1B; EIF4BB; IKBKB; HIF1AB
PIK-Akt signaling pathway
GNGT2; YWHAG; IL7R; RAC1; GNGT1; FLT1; TNC; LAMA3; GNG10; FGF12
Insulin signaling pathway
CALM1B; PRKAG3; PRKAB1B; PPP1R3A; RPS6KB1; SOCS2; FLOT1; MKNK1; PYGM; PDE3B
Proteoglycans in cancer
FLNC; SDC2; TWIST2; MAPK3; FN1; VAV2; TWIST1; ACTG1; HPSE; ITGA2

Protein Function

RPS6 has several biochemical functions, for example, poly(A) RNA binding, protein binding, protein kinase binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6 itself. We selected most functions RPS6 had, and list some proteins which have the same functions with RPS6. You can find most of the proteins on our site.
Function
Related Protein
Function poly(A) RNA binding
Related Protein EIF1; Txn1; RPL21; RBM7; LARP4B; EXOSC7; RBM27; HDLBP; BUD13; ERI3
Function protein binding
Related Protein TUBB4A; RAB21; RPIA; PDE6H; SPTBN1; EXOSC2; NTSR1; DCD; TNFAIP8L1; UBXN4
Function protein kinase binding
Related Protein KCNH1; PDGFRB; CHEK2; DNM1; PPME1; DVL1; TSKS; PIFO; ADCY6; RPS19
Function structural constituent of ribosome
Related Protein RPL30; RPL14; MRPL2; MRPL49; RPS26L; RPS15; RPS17; MRPL42; MRP63; RPL5B

Interacting Protein

RPS6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6.
STAU1; NCBP1; PASK; ESR1; PPP2R2B; AURKA; ATF4; RPS6KA2; RPS6KA1; RPS6KB2; MAP3K1

RPS6 Related Articles

Osman, AM; van Loveren, H; et al. The immunosuppressant tributyltin oxide blocks the mTOR pathway, like rapamycin, albeit by a different mechanism. JOURNAL OF APPLIED TOXICOLOGY 34:1361-1367(2014).
von der Heyde, S; Bender, C; et al. Boolean ErbB network reconstructions and perturbation simulations reveal individual drug response in different breast cancer cell lines. BMC SYSTEMS BIOLOGY 8:-(2014).