rps6kb2
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  • Official Full Name
  • ribosomal protein S6 kinase, 70kDa, polypeptide 2
  • Background
  • This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
  • Synonyms
  • RPS6KB2; ribosomal protein S6 kinase, 70kDa, polypeptide 2; ribosomal protein S6 kinase, 70kD, polypeptide 2; ribosomal protein S6 kinase beta-2; KLS; P70 BETA; p70S6Kb; STK14B; P70S6K2; S6K-beta; p70 S6KB; p70-S6K 2; S6K-beta-2; p70 S6K-beta; p70 S6 kina
Cat.#:RPS6KB2-1935HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KB2 protein, His & GST-tagged
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Cat.#:RPS6KB2-2437HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KB2, His-tagged
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Cat.#:RPS6KB2-30578THTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KB2
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Cat.#:RPS6KB2-30618THTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KB2
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Cat.#:RPS6KB2-360HTag:His/MBP
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RPS6KB2 protein, His/MBP-tagged
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Cat.#:RPS6KB2-14500MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RPS6KB2 Protein
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Cat.#:RPS6KB2-377HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human RPS6KB2, GST-tagged, Active
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Cat.#:RPS6KB2-2158HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human RPS6KB2 293 Cell Lysate
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Involved Pathway

RPS6KB2 involved in several pathways and played different roles in them. We selected most pathways RPS6KB2 participated on our site, such as ErbB signaling pathway, HIF- signaling pathway, mTOR signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with RPS6KB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
ErbB signaling pathway
PIK3R2; ERBB4; CDKN1BB; CAMK2D2; PTK2AA; STAT5B; STAT5A; RPS6KB2; SOS1; PRKCB
HIF- signaling pathway
GM5506; CAMK2B; SERPINE1; TFRC; PIK3CA; ANGPT4; TIMP1; MAPK1; HK3; CAMK2A
mTOR signaling pathway
MAPK1; PRKCA; RRAGCA; ULK1; IKBKB; RHEB; RPS6KAL; PIK3R2; RRN3; EIF4E1C
PIK-Akt signaling pathway
TSC2; PRKAA2; FLT1; IFNA16; LPAR5; PPP2R2D; MAPK1; GNGT1; PPP2R2A; LPAR6
AMPK signaling pathway
ELAVL1; ADIPOR2; CPT1C; FBP2; PPP2R1B; CREB3; GYS1; CCNA1; EIF4EBP1; ACACA
TGF-beta signaling pathway
BMP7A; RHOAC; BMP7B; BMP2B; TNF; BAMBIA; CUL1; INHBC; BMP4; THBS1
Fc gamma R-mediated phagocytosis
SPHK2; MAP2K1; WAS; FCGR1; HCK; PIK3R2; PRKCB; LIMK2; cgr2b; WASL
Insulin signaling pathway
MAP2K2; SHC4; G6PC2; SHC1; INSB; TRIP10A; PRKACB; SOS1; PRKAR2B; PHKG1B
Insulin resistance
PPARGC1A; IL6; TRIB3; SOCS3B; GSK3AA; INS2; INS1; TNFRSF1A; RPS6KA3A; PPP1CAA
Proteoglycans in cancer
WNT16; WNT4; CAMK2G; IL12B; ITGB3; TLR2; RPS6; PTCH1; FLNC; VAV2
Acute myeloid leukemia
RARA; KRAS; RUNX1T1; RPS6KB1; MAP2K2; ARAF; JUP; BAD; SOS1; CCND1
Choline metabolism in cancer
PLD1; EGF; Pdgfa&Pdgfb; PLCG1; NRAS; DGKB; TSC2; SP1; SLC22A5; PDGFD

Protein Function

RPS6KB2 has several biochemical functions, for example, ATP binding, peptide binding, protein kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RPS6KB2 itself. We selected most functions RPS6KB2 had, and list some proteins which have the same functions with RPS6KB2. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein NARS; RAF1B; DGKA; TLK1B; SEPHS2; PAK2A; CDK20; UBA7; PKN1; KIF2A
Function peptide binding
Related Protein GPR37; QRFPR; OXTRL; NLN; NPFFR2; TPP1; ERAP1; CTSB; HCRTR1; LNPEP
Function protein kinase activity
Related Protein AURKC; NAT1; PRKACAB; MAPK14B; KALRN; NPRL2; TNK2B; PTK2AB; CSNK1G3; LRRK2
Function protein serine/threonine kinase activity
Related Protein BMPR1AB; CSNK1A1; PINK1; IRAK3; FAM20C; MAP2K1; MAPK8A; CLK3; ACVR1BA; NLK2
Function ribosomal protein S6 kinase activity
Related Protein RPS6KB1; RPS6KA3B; RPS6KA1; RPS6KA4; RPS6KA6; RPS6KB1B; RPS6KA3A; RPS6KB2; ALPK2; RPS6KA2

Interacting Protein

RPS6KB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RPS6KB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of RPS6KB2.
RPS6; CSNK2B; SRPK1; COASY; ATP5A1; MAPK8IP2; SNW1; CDC5L; EEF2K