Recombinant Full Length Human RPS6KB2 Protein, C-Flag-tagged

• Cat.No.: RPS6KB2-1988HFL
• Product Overview: Recombinant Full Length Human RPS6KB2 Protein, fused to Flag-tag at C-terminus, was expressed in Mammalian cells.

Specification

• Description: This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains a kinase catalytic domain and phosphorylates the S6 ribosomal protein and eukaryotic translation initiation factor 4B (eIF4B). Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
• Source: Mammalian cells
• Species: Human
• Tag: Flag
• Form: 25 mM Tris HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 53.3 kDa
• AA Sequence: MAAVFDLDLETEEGSEGEGEPELSP ADACPLAELRAAGLEPVGHYEEVEL TETSVNVGPERIGPHCFELL RVLGKGGYGKVFQVRKVQGTNLGKI YAMKVLRKAKIVRNAKDTAHTRAER NILESVKHPFIVELAYAFQT GGKLYLILECLSGGELFTHLEREGI FLEDTACFYLAEITLALGHLHSQGI IYRDLKPENIMLSSQGHIKL TDFGLCKESIHEGAVTHTFCGTIEY MAPEILVRSGHNRAVDWWSLGALMY DMLTGSPPFTAENRKKTMDK IIRGKLALPPYLTPDARDLVKKFLK RNPSQRIGGGPGDAADVQRHPFFRH MNWDDLLAWRVDPPFRPCLQ SEEDVSQFDTRFTRQTPVDSPDDTA LSESANQAFLGFTYVAPSVLDSIKE GFSFQPKLRSPRRLNSSPRV PVSPLKFSPFEGFRPSPSLPEPTEL PLPPLLPPPPPSTTAPLPIRPPSGT KKSKRGRGRPGR TRTRPLEQKLISEEDLAANDILDYK DDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining.
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 ug/mL as determined by microplate BCA method.
• Preparation: Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps.
• Protein Families: Druggable Genome, Protein Kinase
• Protein Pathways: Acute myeloid leukemia, ErbB signaling pathway, Fc gamma R-mediated phagocytosis, Insulin signaling pathway, mTOR signaling pathway, TGF-beta signaling pathway

Gene Information

• Gene Name: RPS6KB2 ribosomal protein S6 kinase B2 [ Homo sapiens (human) ]
• Official Symbol: RPS6KB2
• Synonyms: KLS; SRK; S6K2; S6KB; STK14B; S6KI(2); S6Kbeta; p70S6Kb; P70-beta; S6K-beta2; P70-beta-1; P70-beta-2; p70(S6K)-beta
• Gene ID: 6199
• mRNA Refseq: NM_003952.3
• Protein Refseq: NP_003943.2
• MIM: 608939
• UniProt ID: Q9UBS0