rrm1
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  • Official Full Name
  • ribonucleotide reductase M1
  • Background
  • Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
  • Synonyms
  • RRM1; ribonucleotide reductase M1; ribonucleotide reductase M1 polypeptide; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase, R1 subunit; ribonucleotide reductase, large subunit; ribonucleoside-diphosphate reductase subunit M1; R1; RR1; RIR1
Cat.#:RRM1-1509HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human RRM1 Protein (1-792 aa), His-tagged
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Cat.#:RRM1-785HTag:His-SUMO
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM1 Protein (1-792 aa), His-SUMO-tagged
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Cat.#:RRM1-1961HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human RRM1 Protein, MYC/DDK-tagged
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Cat.#:RRM1-374HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM1 Protein, His-tagged
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Cat.#:RRM1-2444HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human RRM1, GST-tagged
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Cat.#:RRM1-29473THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human RRM1
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Cat.#:RRM1-8650HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RRM1, His-GST tagged
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Cat.#:RRM1-14524MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse RRM1 Protein
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Cat.#:RRM1-4036RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey RRM1 Protein, His-tagged
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Cat.#:RRM1-2533CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken RRM1
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Cat.#:RRM1-9023ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish RRM1
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Cat.#:RRM1-001HCLTag:
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human RRM1 cell lysate
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Involved Pathway

RRM1 involved in several pathways and played different roles in them. We selected most pathways RRM1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Purine metabolism
GUK1B; PDE4A; ENTPD8; POLR3B; AK7B; POLE3; POLR1D; AK8; GART; CANT1
Pyrimidine metabolism
DPYS; POLR2K; DUT; NT5C2; PRIM1; UMPS; POLE4; POLR2I; POLR1B; TXNRD2
Glutathione metabolism
GSTM; GPX7; GPX4; GSTA2; GSTA4; GGT1; RRM1; GGCT; GSTP1; ODC1
Metabolic pathways
ITPK1A; PAPSS2; MVD; AHCY; ALDOAA; NOS2; LPCAT2; PDHA1; LDHC; AK5

Protein Function

RRM1 has several biochemical functions, for example, ATP binding, protein binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM1 itself. We selected most functions RRM1 had, and list some proteins which have the same functions with RRM1. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein KIF7; EPHB4B; ADCK2; GUCY2E; EPHA2; C10orf2; IRAK2; CDC7; IGF1R; HSP90B1
Function protein binding
Related Protein TGIF1; DYX1C1; BCL2L2; MAGEA4; SUZ12; GAGE8; HIF1A; MTX2; LSM5; SDCBP
Function ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Related Protein RRM1; RRM2B; RRM2

Interacting Protein

RRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM1.
RRM2; MCC; HLA-B; EIF6; IKBKE; ATG5; FTSJ1; TNIK; PRKAB1; PPP1CC; RIF1; 15-deoxy-delta(12,14; Ubr5; MYC; RNASEH2B; Cdca8; Cdkn2aip

RRM1 Related Articles

Shodai, A; Morimura, T; et al. Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43). JOURNAL OF BIOLOGICAL CHEMISTRY 288:14886-14905(2013).
Langer, CJ; et al. Exploring biomarkers in head and neck cancer. CANCER 118:3882-3892(2012).