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RRM1

  • Official Full Name

    ribonucleotide reductase M1

  • Overview

    Ribonucleotide reductase M1 polypeptide (RRM1) is one of two non-identical subunits for ribonucleoside-diphosphate reductase, an enzyme which catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RRM1 is present throughout the cell division cycle but downregulated in quiescent cells. RRM1 is involved in carcinogenesis, tumor progression, and the response of non-small-cell lung cancer (NSCLC) to chemotherapy.
  • Synonyms

    RRM1; ribonucleotide reductase M1; ribonucleotide reductase M1 polypeptide; ribonucleoside-diphosphate reductase large subunit; ribonucleotide reductase, R1 subunit; ribonucleotide reductase, large subunit; ribonucleoside-diphosphate reductase subunit M1; R1; RR1; RIR1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|SUMO
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human RRM1-2444H Recombinant Human RRM1, GST-tagged E.coli GST 593-792
Human RRM1-29473TH Recombinant Human RRM1 Wheat Germ N/A 110 amino acids
Human RRM1-8650H Recombinant Human RRM1, His-GST tagged Insect Cell His
Human RRM1-001HCL Recombinant Human RRM1 cell lysate Insect Cell N/A
Human RRM1-785H Recombinant Human RRM1 Protein (1-792 aa), His-SUMO-tagged E.coli His/SUMO 1-792 aa
Human RRM1-179HFL Active Recombinant Full Length Human RRM1 Protein, C-Flag-tagged Mammalian cells Flag
Human RRM1-1961H Recombinant Human RRM1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human RRM1-1318H Recombinant Human RRM1 protein(Met1-Ser792), His&GST-tagged Insect Cells N-His&GST Met1-Ser792
Human RRM1-1921H Recombinant Human RRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human RRM1-6205H Recombinant Human RRM1 Protein (Met1-Pro213), His tagged E.coli His Met1-Pro213
Human RRM1-1921H-B Recombinant Human RRM1 Protein Pre-coupled Magnetic Beads HEK293
Human RRM1-374H Recombinant Human RRM1 Protein, His-tagged E.coli His Met1~Pro213
Human RRM1-1509H Recombinant Human RRM1 Protein (1-792 aa), His-tagged Yeast His 1-792 aa
Mouse RRM1-14524M Recombinant Mouse RRM1 Protein Mammalian Cell His
Mouse Rrm1-5626M Recombinant Mouse Rrm1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse RRM1-7813M-B Recombinant Mouse RRM1 Protein Pre-coupled Magnetic Beads HEK293
Mouse RRM1-7813M Recombinant Mouse RRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque RRM1-4036R Recombinant Rhesus monkey RRM1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque RRM1-3853R-B Recombinant Rhesus Macaque RRM1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque RRM1-3853R Recombinant Rhesus Macaque RRM1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish RRM1-9023Z Recombinant Zebrafish RRM1 Mammalian Cell His
Chicken RRM1-2533C Recombinant Chicken RRM1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • RRM1 Related Articles

RRM1 involved in several pathways and played different roles in them. We selected most pathways RRM1 participated on our site, such as Purine metabolism, Pyrimidine metabolism, Glutathione metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with RRM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Purine metabolismGUCY1A3;POLR2B;DGUOK;AK3;POLD2;AK7B;NPR1;PNP5A;POLA2
Pyrimidine metabolismPRIM1;POLR2EB;POLR2A;PNP6;NME4;POLR2F;POLD4;POLR2J2;POLE3
Glutathione metabolismGPX4A;ANPEPB;MGST1;GSTT2B;ODC1;GSTO1;RRM2B;IDH1;GSTA2
Metabolic pathwaysLIPCA;AANAT;GBGT1L4;ACSL1B;RDH8;SMPD3;GPT2L;A4GALT;DSE

RRM1 has several biochemical functions, for example, ATP binding, protein binding, ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Some of the functions are cooperated with other proteins, some of the functions could acted by RRM1 itself. We selected most functions RRM1 had, and list some proteins which have the same functions with RRM1. You can find most of the proteins on our site.

Function Related Protein
ATP bindingCHD6;KIF12;PRKCBB;HSP70;MCCC1;DGKG;ERCC3;PFKFB2;KIF5C
protein bindingUBL7;IPO13;PSEN2;SIGLEC5;DEFA6;HIST1H2BE;CCNB1IP1;PIM2;NCOA5
ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptorRRM2B;RRM2;RRM1

RRM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RRM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of RRM1.

RRM2; MCC; HLA-B; EIF6; IKBKE; ATG5; FTSJ1; TNIK; PRKAB1; PPP1CC; RIF1; 15-deoxy-delta(12,14; Ubr5; MYC; RNASEH2B; Cdca8; Cdkn2aip

Shodai, A; Morimura, T; et al. Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43). JOURNAL OF BIOLOGICAL CHEMISTRY 288:14886-14905(2013).
Langer, CJ; et al. Exploring biomarkers in head and neck cancer. CANCER 118:3882-3892(2012).
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