ren1
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  • Official Full Name
  • Renin 1 Structural
  • Background
  • Renin catalyzes the first step in the activation pathway of angiotensinogen--a cascade that can result in aldosterone release, vasoconstriction, and increase in blood pressure. Renin, an aspartyl protease, cleaves angiotensinogen to form angiotensin I, which is converted to angiotensin II by angiotensin I converting enzyme, an important regulator of blood pressure and electrolyte balance. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause familial hyperproreninemia.
  • Synonyms
  • Ren1; renin 1 structural; Ren; Rnr; Rn-1; Ren-1; Ren-A; Ren1c; Ren1d; D19352; renin-1; renin b; kidney renin; aspartyl-protease; OTTMUSP00000024128; angiotensinogenase; renin; EC 3.4.23.15; renin precursor, renal; HNFJ2; FLJ107612; EC 3.4.238; angiotensin-forming enzyme; Prorenin; FLJ10761; RENAA; Renin precursor renal; Angiotensin forming enzyme
Cat.#:REN1-14072MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse REN1 Protein
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Cat.#:Ren1-2305MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Ren1, His tagged
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Cat.#:Ren1-379MTag:His
Source (Host):Insect cellSpecies:Mouse
Product nameRecombinant Mouse Ren1 Protein, His-tagged
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Cat.#:Ren1-7885MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ren1 protein, His-tagged
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Cat.#:Ren1-7886MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ren1 protein, His-tagged
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Cat.#:REN-2576MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse REN cell lysate
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Involved Pathway

Ren1 involved in several pathways and played different roles in them. We selected most pathways Ren1 participated on our site, such as Renin-angiotensin system, Renin secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with Ren1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Renin-angiotensin system
AGTR1B; PREP; CPA3; KLK1B1; ATP6AP2; MRGPRD; ENPEP; KLK1B22; LNPEP; ACE2
Renin secretion
PPP3R2; PRKACG; PLCB4; CALM3; GUCY1B3; CLCA1; REN; PPP3CC; GNAI1; Ren1

Protein Function

Ren1 has several biochemical functions, for example, aspartic-type endopeptidase activity, endopeptidase activity, hydrolase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Ren1 itself. We selected most functions Ren1 had, and list some proteins which have the same functions with Ren1. You can find most of the proteins on our site.
Function
Related Protein
Function aspartic-type endopeptidase activity
Related Protein PIP; NRIP3; SPPL3; CTSD; PGA4; ANK2B; Ren1; REN2; DDI2; NOTS
Function endopeptidase activity
Related Protein ADAM10; ATG4B; KLK1B11; CPNE1; PSMB4; SENP3B; KLK1B4; PSMA6A; PSMB2; KLK1B1
Function hydrolase activity
Related Protein DUSP8A; OTUB1B; NUDT17; SETX; PPM1H; PNPLA5; ABHD14A; DHX33; RNASEKB; GNPDA1
Function insulin-like growth factor receptor binding
Related Protein PIK3R1; INSR; IGF2; INS; IGF2B; SHC1; IGF1; SOCS1; REN; INSL4
Function peptidase activity
Related Protein GM5077; HE1B; PSMA6B; CAPN2L; PM20D1.2; CTSBA; SPINT1A; TMPRSS13B; ASTL; SPCS1
Function receptor binding
Related Protein TESPA1; HAO2; GRIN2A; MBL2; FGF10A; WNT4A; CADM3; FGF18A; PSPN; PPY

Interacting Protein

Ren1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Ren1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Ren1.
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Ren1 Related Articles

Cuffe, JSM; Walton, SL; et al. The effects of gestational age and maternal hypoxia on the placental renin angiotensin system in the mouse. PLACENTA 35:953-961(2014).
Xa, LK; Lacombe, MJ; et al. General lysosomal hydrolysis can process prorenin accurately. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY 307:R505-R513(2014).