SEMA5A
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Official Full Name
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
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Overview
This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010] -
Synonyms
SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; semF; SEMAF; semaphorin-5A; sema F; semaphorin F; semaphorin-F; semaphorin 5A;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- Rhesus Macaque
- Zebrafish
- CHO
- E.coli
- HEK293
- HEK293T
- Human Cell
- Mammalian Cell
- Mammalian cells
- C
- His
- Fc
- Fc Chimera
- Flag
- hFc
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- SEMA5A Related Articles
- SEMA5A Related Research Area
SEMA5A involved in several pathways and played different roles in them. We selected most pathways SEMA5A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Axon guidance | PEA15A;ARPC2;PPP3CA;ARPC4;RASA1;CNKSR1;NTN1A;SPRED2;ABLIM2 |
SEMA5A has several biochemical functions, for example, axon guidance receptor activity, chemorepellent activity, chondroitin sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA5A itself. We selected most functions SEMA5A had, and list some proteins which have the same functions with SEMA5A. You can find most of the proteins on our site.
Function | Related Protein |
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axon guidance receptor activity | SEMA5A;EPHA7;GFRA3;EPHB1;ROBO2;EPHB3;ROBO1 |
chemorepellent activity | SEMA3B;FLRT2;SEMA3G;SEMA6DL;UBE4A;SEMA4B;SEMA5B;SEMA3AB;SEMA4C |
chondroitin sulfate proteoglycan binding | PTPRF;SEMA5A;PTN;COL20A1 |
heparan sulfate proteoglycan binding | AZU1;COMP;HRG;GPC1;UBE4A;AGRN;SLIT2;GPC1B;ITGAM |
semaphorin receptor binding | SEMA3GA;SEMA4D;SEMA3BL;SEMA3B;SEMA3AA;SEMA3A;SEMA6DL;SEMA3GB;SEMA3H |
syndecan binding | TNC;CHRD;HPSE;SEMA5A;SDCBP |
SEMA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA5A.
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- Q&As
- Reviews
Q&As (7)
Ask a questionSemaphorin-5A (SEMA5A) functions in cellular processes, primarily playing a role in neural development and axon guidance.
SEMA5A is predominantly localized in growth cones and axonal pathways within the nervous system.
There are potential therapeutic implications related to SEMA5A in neurological disorders involving neural development, making it a target for drug development.
SEMA5A participates in axon guidance and neuronal migration during neural development by interacting with Plexin-A and Neuropilin-1 receptors.
Specific receptors or co-receptors that SEMA5A interacts with include Plexin-A and Neuropilin-1, influencing its role in neural circuit formation.
SEMA5A contributes to the regulation of synaptic connectivity and plasticity in the nervous system, impacting neural circuit formation.
Dysregulation or abnormal expression of SEMA5A is associated with conditions such as autism spectrum disorders and developmental disorders.
Customer Reviews (3)
Write a reviewThe product's consistent outcomes fortified the reproducibility of our scientific inquiries.
Despite its cost, the product's contributions to our research goals made it an invaluable asset.
We appreciated the product's efficiency in achieving target protein upregulation with minimal time investment.
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