sema5a
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  • Official Full Name
  • sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
  • Background
  • This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
  • Synonyms
  • SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; semF; SEMAF; semaphorin-5A; sema F; semaphorin F; semaphorin-F; semaphorin 5A;
Cat.#:SEMA5A-603HTag:Myc|DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA5A Protein, MYC/DDK-tagged
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Cat.#:SEMA5A-234HTag:Fc Chimera
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human SEMA5A, Fc Chimera
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Cat.#:SEMA5A-3240HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA5A, His tagged
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Cat.#:SEMA5A-3894HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA5A, Fc tagged
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Cat.#:SMA5A-3511HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SEMA5A, MIgG2a Fc-tagged
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Cat.#:SMA5A-3512HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SEMA5A, HIgG1 Fc-tagged
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Cat.#:Sema5a-617MTag:Fc
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Sema5a Protein, Fc Chimera
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Cat.#:Sema5a-8692MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sema5a, His tagged
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Cat.#:SEMA5A-5314RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SEMA5A Protein
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Cat.#:SEMA5A-4135RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SEMA5A Protein, His-tagged
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Cat.#:SEMA5A-8267ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SEMA5A
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Cat.#:SEMA5A-1860HCLTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human SEMA5A cell lysate
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Cat.#:SEMA5A-1310MCLTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SEMA5A cell lysate
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Involved Pathway

SEMA5A involved in several pathways and played different roles in them. We selected most pathways SEMA5A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Axon guidance
CSF2RB; UNC5C; AP2S1; CNKSR1; FES; FGF20A; EVL; SEMA4B; TRPC5; ABLIM2

Protein Function

SEMA5A has several biochemical functions, for example, axon guidance receptor activity, chemorepellent activity, chondroitin sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA5A itself. We selected most functions SEMA5A had, and list some proteins which have the same functions with SEMA5A. You can find most of the proteins on our site.
Function
Related Protein
Function axon guidance receptor activity
Related Protein EPHB1; SEMA5A; GFRA3; ROBO1; ROBO2; EPHA7; EPHB3
Function chemorepellent activity
Related Protein FLRT3; SEMA3AA; SEMA4A; SEMA4B; SEMA3G; SEMA3GA; EFNA5; SEMA3E; SEMA4C; FLRT2
Function chondroitin sulfate proteoglycan binding
Related Protein SEMA5A; PTN; PTPRF; COL20A1
Function heparan sulfate proteoglycan binding
Related Protein GPC1; Gpc2; UBE4A; CFH; AGRN; FST; SLIT2; SEMA5A; ITGAM; GPC3
Function semaphorin receptor binding
Related Protein SEMA6DL; SEMA3GA; SEMA3C; SEMA4D; SEMA3E; SEMA6E; SEMA3B; SEMA3BL; SEMA3AA; SEMA4C
Function syndecan binding
Related Protein HPSE; TNC; SDCBP; SEMA5A; CHRD

Interacting Protein

SEMA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA5A.
fhaC2

SEMA5A Related Articles

Goldberg, JL; Vargas, ME; et al. An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells. JOURNAL OF NEUROSCIENCE 24:4989-4999(2004).
Oster, SF; Bodeker, MO; et al. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. DEVELOPMENT 130:775-784(2003).