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SEMA5A

  • Official Full Name

    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A

  • Overview

    This gene belongs to the semaphorin gene family that encodes membrane proteins containing a semaphorin domain and several thrombospondin type-1 repeats. Members of this family are involved in axonal guidance during neural development. This gene has been implicated as an autism susceptibility gene.[provided by RefSeq, Jan 2010]
  • Synonyms

    SEMA5A; sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A; semF; SEMAF; semaphorin-5A; sema F; semaphorin F; semaphorin-F; semaphorin 5A;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Mammalian Cell
  • Mammalian cells
  • C
  • His
  • Fc
  • Fc Chimera
  • Flag
  • hFc
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SMA5A-3511H Active Recombinant Human SEMA5A, MIgG2a Fc-tagged CHO Fc
Human SEMA5A-234H Active Recombinant Human SEMA5A, Fc Chimera Mammalian cells Fc Chimera
Human SMA5A-3512H Active Recombinant Human SEMA5A, HIgG1 Fc-tagged CHO Fc
Human SEMA5A-3240H Recombinant Human SEMA5A protein, His-tagged HEK293 His Met1-Met968
Human SEMA5A-3894H Recombinant Human SEMA5A protein, hFc-tagged HEK293 hFc Met1-Thr765
Human SEMA5A-1860HCL Recombinant Human SEMA5A cell lysate Human Cell N/A
Human SEMA5A-2680H Recombinant Human SEMA5A Protein, His-tagged E.coli N-His Val319-Gln668
Human SEMA5A-6683H Recombinant Human SEMA5A Protein (Val319-Gln668), His tagged E.coli His Val319-Gln668
Human SEMA5A-6684H Recombinant Human SEMA5A Protein (Glu23-Thr765), C-His tagged Mammalian cells C-His Glu23-Thr765
Human SEMA5A-1969H Recombinant Human SEMA5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human SEMA5A-1015HFL Recombinant Full Length Human SEMA5A Protein, C-Flag-tagged Mammalian cells Flag
Human SEMA5A-1969H-B Recombinant Human SEMA5A Protein Pre-coupled Magnetic Beads HEK293
Human SEMA5A-603H Recombinant Human SEMA5A Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SEMA5A-4337H Recombinant Human SEMA5A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Mouse Sema5a-617M Active Recombinant Mouse Sema5a Protein, Fc Chimera CHO Fc
Mouse Sema5a-8692M Recombinant Mouse Sema5a protein(Met1-Thr765), His-tagged HEK293 C-His Met1-Thr765
Mouse SEMA5A-1310MCL Recombinant Mouse SEMA5A cell lysate Human Cell N/A
Mouse Sema5a-5762M Recombinant Mouse Sema5a Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rat SEMA5A-5314R Recombinant Rat SEMA5A Protein Mammalian Cell His
Rat SEMA5A-4973R Recombinant Rat SEMA5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat SEMA5A-4973R-B Recombinant Rat SEMA5A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SEMA5A-4135R Recombinant Rhesus monkey SEMA5A Protein, His-tagged Mammalian Cell His
Rhesus Macaque SEMA5A-3952R-B Recombinant Rhesus Macaque SEMA5A Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque SEMA5A-3952R Recombinant Rhesus Macaque SEMA5A Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Zebrafish SEMA5A-8267Z Recombinant Zebrafish SEMA5A Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SEMA5A Related Articles
  • SEMA5A Related Research Area

SEMA5A involved in several pathways and played different roles in them. We selected most pathways SEMA5A participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with SEMA5A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidancePEA15A;ARPC2;PPP3CA;ARPC4;RASA1;CNKSR1;NTN1A;SPRED2;ABLIM2

SEMA5A has several biochemical functions, for example, axon guidance receptor activity, chemorepellent activity, chondroitin sulfate proteoglycan binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SEMA5A itself. We selected most functions SEMA5A had, and list some proteins which have the same functions with SEMA5A. You can find most of the proteins on our site.

Function Related Protein
axon guidance receptor activitySEMA5A;EPHA7;GFRA3;EPHB1;ROBO2;EPHB3;ROBO1
chemorepellent activitySEMA3B;FLRT2;SEMA3G;SEMA6DL;UBE4A;SEMA4B;SEMA5B;SEMA3AB;SEMA4C
chondroitin sulfate proteoglycan bindingPTPRF;SEMA5A;PTN;COL20A1
heparan sulfate proteoglycan bindingAZU1;COMP;HRG;GPC1;UBE4A;AGRN;SLIT2;GPC1B;ITGAM
semaphorin receptor bindingSEMA3GA;SEMA4D;SEMA3BL;SEMA3B;SEMA3AA;SEMA3A;SEMA6DL;SEMA3GB;SEMA3H
syndecan bindingTNC;CHRD;HPSE;SEMA5A;SDCBP

SEMA5A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SEMA5A here. Most of them are supplied by our site. Hope this information will be useful for your research of SEMA5A.

fhaC2

Goldberg, JL; Vargas, ME; et al. An oligodendrocyte lineage-specific semaphorin, sema5A, inhibits axon growth by retinal ganglion cells. JOURNAL OF NEUROSCIENCE 24:4989-4999(2004).
Oster, SF; Bodeker, MO; et al. Invariant Sema5A inhibition serves an ensheathing function during optic nerve development. DEVELOPMENT 130:775-784(2003).
  • Q&As
  • Reviews

Q&As (7)

Ask a question
What is the primary function of Semaphorin-5A (SEMA5A) in cellular processes and neural development? 06/10/2021

Semaphorin-5A (SEMA5A) functions in cellular processes, primarily playing a role in neural development and axon guidance.

In which cellular compartments is SEMA5A predominantly localized, especially within the nervous system? 11/27/2019

SEMA5A is predominantly localized in growth cones and axonal pathways within the nervous system.

Are there therapeutic implications or potential targets related to SEMA5A in neurological disorders involving neural development? 08/10/2018

There are potential therapeutic implications related to SEMA5A in neurological disorders involving neural development, making it a target for drug development.

How does SEMA5A participate in axon guidance and neuronal migration during neural development? 05/25/2018

SEMA5A participates in axon guidance and neuronal migration during neural development by interacting with Plexin-A and Neuropilin-1 receptors.

Are there specific receptors or co-receptors that SEMA5A interacts with, influencing its role in neural circuit formation? 02/27/2018

Specific receptors or co-receptors that SEMA5A interacts with include Plexin-A and Neuropilin-1, influencing its role in neural circuit formation.

How does SEMA5A contribute to the regulation of synaptic connectivity and plasticity in the nervous system? 09/05/2016

SEMA5A contributes to the regulation of synaptic connectivity and plasticity in the nervous system, impacting neural circuit formation.

What diseases or conditions are associated with dysregulation or abnormal expression of SEMA5A? 05/11/2016

Dysregulation or abnormal expression of SEMA5A is associated with conditions such as autism spectrum disorders and developmental disorders.

Customer Reviews (3)

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Reviews
11/15/2022

    The product's consistent outcomes fortified the reproducibility of our scientific inquiries.

    03/26/2021

      Despite its cost, the product's contributions to our research goals made it an invaluable asset.

      03/09/2019

        We appreciated the product's efficiency in achieving target protein upregulation with minimal time investment.

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