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SERPINB6

  • Official Full Name

    serpin peptidase inhibitor, clade B (ovalbumin), member 6

  • Overview

    The protein encoded by this gene is a member of the serpin (serine proteinase inhibitor) superfamily, and ovalbumin(ov)-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
  • Synonyms

    SERPINB6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; deafness, autosomal recessive 91 , DFNB91, PI6, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; serpin B6; CAP; cytoplasmic antiproteinase; PTI; MGC111370; MSTP057; Peptidase inhibitor 6; PI 6; PI-6; PI6; Placental thrombin inhibitor; Protease inhibitor 6; Protease inhibitor 6 (placental thrombin inhibitor); Serpin peptidase inhibitor clade B (ovalbumin) member 6; SPB6_HUMAN; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; SPI3; DFNB91;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Cynomolgus Monkey
  • Human
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • His
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Trx
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human SERPINB6-7025H Recombinant Human SERPINB6 protein, His-tagged Insect Cells His Asp2-Pro376
Human SERPINB6-2595H Recombinant Human SERPINB6, His-tagged E.coli His 1-376aa
Human SERPINB6-7781H Recombinant Human SERPINB6, His-tagged E.coli His
Human SERPINB6-553HCL Recombinant Human SERPINB6 cell lysate Insect Cell N/A
Human SERPINB6-1009H Recombinant Human SERPINB6 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human SERPINB6-1071H Recombinant Human SERPINB6 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human SERPINB6-5915H Recombinant Human SERPINB6 Protein (Met1-Pro376), N-His and Trx tagged E.coli N-His and Trx Met1-Pro376
Cynomolgus Monkey SERPINB6-912C Recombinant Cynomolgus SERPINB6 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey SERPINB6-655C Recombinant Cynomolgus Monkey SERPINB6 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey SERPINB6-655C-B Recombinant Cynomolgus Monkey SERPINB6 Protein Pre-coupled Magnetic Beads HEK293
Chicken SERPINB6-1520C Recombinant Chicken SERPINB6 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • SERPINB6 Related Articles
  • SERPINB6 Related Research Area

SERPINB6 involved in several pathways and played different roles in them. We selected most pathways SERPINB6 participated on our site, such as Amoebiasis, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINB6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisPIK3CG;COL2A1;TGFB1;C8A;LAMC1;PIK3R1;CD14;RAB7;RELA

SERPINB6 has several biochemical functions, for example, protease binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINB6 itself. We selected most functions SERPINB6 had, and list some proteins which have the same functions with SERPINB6. You can find most of the proteins on our site.

Function Related Protein
protease bindingSERPINA1E;SEMG2;INS2;SERPINF2;BCL2;Cstb;TIMP1;TRIP4;BRCA2
serine-type endopeptidase inhibitor activitySERPINB7;SERPINB1B;SERPINH1;SPINT4;A1i3;SERPINB13;SERPINA1E;TFPI;SPINK3

SERPINB6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINB6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINB6.

CEP170P1; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate

Nishida, Y; Aida, K; et al. Antibody-Validated Proteins in Inflamed Islets of Fulminant Type 1 Diabetes Profiled by Laser-Capture Microdissection Followed by Mass Spectrometry. PLOS ONE 9:-(2014).
Strik, MCM; Wolbink, A; et al. Intracellular serpin SERPINB6 (PI6) is abundantly expressed by human mast cells and forms complexes with beta-tryptase monomers. BLOOD 103:2710-2717(2004).
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