serpinh1
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  • Official Full Name
  • serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
  • Background
  • This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
  • Synonyms
  • SERPINH1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2; serpin H1; colligin-1; colligin-2; 47 kDa heat shock protein; arsenic-transactivated protein 3; rheumatoid arthritis antigen A-47; cell proliferation-inducing gene 14 protein; rheumatoid arthritis-related antigen RA-A47; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2);
Cat.#:SERPINH1-2602HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINH1, GST-tagged
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Cat.#:SERPINH1-28425THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SERPINH1, His-tagged
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Cat.#:SERPINH1-822HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human SERPINH1 Protein, His-tagged
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Cat.#:SERPINH1-14964MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse SERPINH1 Protein
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Cat.#:SERPINH1-5346RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SERPINH1 Protein
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Cat.#:SERPINH1-4155RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SERPINH1 Protein, His-tagged
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Cat.#:SERPINH1-6843CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SERPINH1
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Cat.#:SERPINH1-1936HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SERPINH1 293 Cell Lysate
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Involved Pathway

SERPINH1 involved in several pathways and played different roles in them. We selected most pathways SERPINH1 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen formation, Endochondral Ossification, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINH1 were listed below. Creative Biomart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Collagen biosynthesis and modifying enzymes
COL13A1; CRTAP; PPIB; COL8A2; EMID2; COL6A3; TLDC2; BMP1B; COL28A1; PCOLCE2B
Collagen formation
COL4A6; BMP1A; PCOLCE; EMID2; LEPRE1; COL11A1B; LOXL3; PCOLCEB; TLL2; COL6A3
Endochondral Ossification
CST5; PTHLH; RUNX2A; SERPINH1; SOX6; ADAMTS4; NKX3-2; PTHLHA; CTSL2; CDKN1C
Extracellular matrix organization
ICAM4; ADAM8; COMP; COL28A1A; COL16A1; COL17A1; MMP24; CTSB; COL19A1; COL4A4

Protein Function

SERPINH1 has several biochemical functions, for example, collagen binding, poly(A) RNA binding, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINH1 itself. We selected most functions SERPINH1 had, and list some proteins which have the same functions with SERPINH1. You can find most of the proteins on our site.
Function
Related Protein
Function collagen binding
Related Protein CTSB; PCOLCE2; Pdgfa&Pdgfb; GPR56; DDR2; ITGA3; CHADL; GP5; NID2; CD44
Function poly(A) RNA binding
Related Protein ATP5C1; PIN4; RPS12; DDX39; GTL3; LARP4; HOXB6; HDLBP; RBM4; RBM34
Function serine-type endopeptidase inhibitor activity
Related Protein PAPLNB; SERPINA3C; SERPINA5; A2ML1; SPINK13; AMBP; SERPINA10A; TFPI; ITIH3; SPINK7
Function unfolded protein binding
Related Protein ERLEC1; DNAJB5; CRYAA; NAP1L4; GRXCR2; CALR3B; CALR; TUBB4B; CCT5; AIPL1

Interacting Protein

SERPINH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINH1.
TSC22D1; CRELD2; nrdR; SLC35F6; CEP70; FEZ1; NSG2; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; MYC; ESR1; env; ATF2; GABARAPL2; GRB2; YBX1; IQCB1; AARSD1

SERPINH1 Related Articles

Saeed, H; Iqtedar, M; et al. Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs). JOURNAL OF BIOMEDICAL SCIENCE 22:-(2015).
Yoo, Y; Byun, K; et al. Amyloid-Beta-Activated Human Microglial Cells Through ER-Resident Proteins. JOURNAL OF PROTEOME RESEARCH 14:214-223(2015).