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Official Full Name serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
Background This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Synonyms SERPINH1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); CBP1; CBP2; OI10; gp46; AsTP3; HSP47; PIG14; PPROM; RA-A47; SERPINH2; serpin H1; colligin-1; colligin-2; 47 kDa heat shock protein; arsenic-transactivated protein 3; rheumatoid arthritis antigen A-47; cell proliferation-inducing gene 14 protein; rheumatoid arthritis-related antigen RA-A47; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2, (collagen-binding protein 2);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Human
    • Mammalian Cell
    • Yeast
    • Tag :
    • GST
    • His
    • SUMO
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse SERPINH1-1516M Recombinant Mouse SERPINH1 Protein (18-417 aa), His-tagged Yeast His
    Human SERPINH1-329H Recombinant Human SERPINH1 protein, His-tagged HEK293 His
    Mouse SERPINH1-808M Recombinant Mouse SERPINH1 Protein (18-417 aa), His-SUMO-tagged E.coli His/SUMO
    Human SERPINH1-1936HCL Recombinant Human SERPINH1 293 Cell Lysate HEK293 N/A
    Human SERPINH1-2602H Recombinant Human SERPINH1, GST-tagged E.coli GST
    Human SERPINH1-28425TH Recombinant Human SERPINH1, His-tagged E.coli His
    Human SERPINH1-4718H Recombinant Human Serpin Peptidase Inhibitor, Clade H (heat shock protein 47), Member 1, (collagen binding protein 1), His-tagged Human His
    Human SERPINH1-822H Recombinant Human SERPINH1 Protein, His-tagged HEK293 His
    Mouse SERPINH1-14964M Recombinant Mouse SERPINH1 Protein Mammalian Cell His
    Rat SERPINH1-5346R Recombinant Rat SERPINH1 Protein Mammalian Cell His
    Rhesus Macaque SERPINH1-4155R Recombinant Rhesus monkey SERPINH1 Protein, His-tagged Mammalian Cell His
    Chicken SERPINH1-6843C Recombinant Chicken SERPINH1 Mammalian Cell His

    SERPINH1 involved in several pathways and played different roles in them. We selected most pathways SERPINH1 participated on our site, such as content, which may be useful for your reference. Also, other proteins which involved in the same pathway with SERPINH1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen biosynthesis and modifying enzymes COL3A1; COL9A1A; TLDC2; PCOLCE2B; COL13A1; BMP1B; COL28A1D; COL16A1; COL10A1; COL11A1B
    Collagen formation BMP1; COL9A1B; SERPINH1A; COL8A1A; CTSL2; PCOLCE2B; COL17A1; LOXL4; COL16A1; COL8A1
    Endochondral Ossification MMP13; ADAMTS4; FRZB; RUNX2A; COL10A1; COL2A1; SOX9A; CDKN1C; KIF3A; PTH
    Extracellular matrix organization MMP11; F11R.2; COL9A1B; COL15A1B; LEPREL2; COL28A1; EMID2; TIMP2A; CTRB1; MFAP1

    SERPINH1 has several biochemical functions, for example, Content. Some of the functions are cooperated with other proteins, some of the functions could acted by SERPINH1 itself. We selected most functions SERPINH1 had, and list some proteins which have the same functions with SERPINH1. You can find most of the proteins on our site.

    Function Related Protein
    collagen binding VWF; CHADL; MMP13; MMP9; ANTXR1; CTSK; SMAD3; C1QTNF1; ASPN; SERPINH2
    poly(A) RNA binding AGO3; MEPCE; RPS19; SF3B14; CCDC137; SUB1; RPS15; HNRPDL; PCBP2; LRRC59
    serine-type endopeptidase inhibitor activity APPB; ITIH3A; WFDC5; WFDC13; SERPINE3; SERPINA1; MUG2; SERPINB1L2; SERPINB13; APLP2
    unfolded protein binding SPG7; DNAJA3; SERPINH1; SSUH2RS1; CRYABA; NAP1L4; CALR3; DNAJB4; LMAN1; CCDC102A

    SERPINH1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SERPINH1 here. Most of them are supplied by our site. Hope this information will be useful for your research of SERPINH1.

    TSC22D1; CRELD2; nrdR; SLC35F6; CEP70; FEZ1; NSG2; 1-phosphatidyl-1d-myo-inositol 4,5-bisphosphate; 15-deoxy-delta(12,14; MYC; ESR1; env; ATF2; GABARAPL2; GRB2; YBX1; IQCB1; AARSD1

    Saeed, H; Iqtedar, M; et al. Aberrant gene expression profiles, during in vitro osteoblast differentiation, of telomerase deficient mouse bone marrow stromal stem cells (mBMSCs). JOURNAL OF BIOMEDICAL SCIENCE 22:-(2015).
    Yoo, Y; Byun, K; et al. Amyloid-Beta-Activated Human Microglial Cells Through ER-Resident Proteins. JOURNAL OF PROTEOME RESEARCH 14:214-223(2015).

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