sfrp4
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  • Official Full Name
  • secreted frizzled-related protein 4
  • Background
  • Secreted frizzled-related protein 4 (SFRP4) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. The expression of SFRP4 in ventricular myocardium correlates with apoptosis related gene expression. [provided by RefSeq, Jul 2008]
  • Synonyms
  • SFRP4; secreted frizzled-related protein 4; FRP-4; FRPHE; sFRP-4; frizzled protein, human endometrium
Cat.#:SFRP4-359HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP4 Protein, His-tagged
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Cat.#:Sfrp4-362RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sfrp4 Protein, His-tagged
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Cat.#:SFRP4-247HTag:His
Source (Host):CHOSpecies:Human
Product nameRecombinant Human SFRP4 Protein, His-tagged
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Cat.#:SFRP4-2618HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SFRP4, His-tagged
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Cat.#:SFRP4-30079THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human SFRP4
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Cat.#:SFRP4-864HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP4, His tagged
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Cat.#:Sfrp4-863MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Sfrp4, His tagged
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Cat.#:SFRP4-5354RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat SFRP4 Protein
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Cat.#:SFRP4-4174RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey SFRP4 Protein, His-tagged
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Cat.#:SFRP4-2850HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human SFRP4 cell lysate
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Cat.#:SFRP4-2849MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse SFRP4 cell lysate
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Involved Pathway

Sfrp4 involved in several pathways and played different roles in them. We selected most pathways Sfrp4 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Sfrp4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Wnt signaling pathway
CCND1; NLK1; CUL1B; MAPK8; NFATC4; PPP3R2; PRKCA; MAPK9; SFRP2; RAC3B

Protein Function

Sfrp4 has several biochemical functions, for example, NOT G-protein coupled receptor activity, NOT Wnt-activated receptor activity, Wnt-protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by Sfrp4 itself. We selected most functions Sfrp4 had, and list some proteins which have the same functions with Sfrp4. You can find most of the proteins on our site.
Function
Related Protein
Function NOT G-protein coupled receptor activity
Related Protein LGR5; SFRP1; LGR4; SFRP1A; FRZB; LGR6; SZL; SFRP2; SFRP1B; SFRP4
Function NOT Wnt-activated receptor activity
Related Protein SFRP1; SFRP1A; SZL; SFRP1B; SETD6; SFRP4; FRZB; TSPAN12; SFRP2; SMO
Function Wnt-protein binding
Related Protein FZD7B; LRP5; FZD1; FZD7A; FZD8B; LRP2A; FZD3A; SFRP4; SFRP1; SETD6
Function protein binding
Related Protein GATA1A; FBLN1; KLRC1; SPEG; ROPN1L; CHMP2B; ARPIN; FLNA; MYC; IRF7

Interacting Protein

Sfrp4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Sfrp4 here. Most of them are supplied by our site. Hope this information will be useful for your research of Sfrp4.
AURKA; BUB1; NRAS; ERBB2; PFKM; CKMT1B; MCC; p27958-pro_0000037576; CTNNA1; BMPR1A; PIK3CA; PMS2; PTPN12; PTPRJ; SMAD4; PDGFRL; ychF; CDKN2A; AP2M1; DLC1

Sfrp4 Related Articles

Miao, CG; Huang, C; et al. MeCP2 modulates the canonical Wnt pathway activation by targeting SFRP4 in rheumatoid arthritis fibroblast-like synoviocytes in rats. CELLULAR SIGNALLING 25:598-608(2013).
Liu, YA; Kodithuwakku, SP; et al. Excessive ovarian stimulation up-regulates the Wnt-signaling molecule DKK1 in human endometrium and may affect implantation: an in vitro co-culture study. HUMAN REPRODUCTION 25:479-490(2010).