|Official Full Name||sirtuin 6|
|Background||The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as Class III histone deacetylases. The first discovered and best ch|
|Synonyms||SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
SIRT6 involved in several pathways and played different roles in them. We selected most pathways SIRT6 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Central carbon metabolism in cancer||KRAS; TRP53; FLT3; AKT2; PIK3R3; PKM; PIK3R5; PIK3CG; PDGFRB; G6PDX|
SIRT6 has several biochemical functions, for example, NAD(P)+-protein-arginine ADP-ribosyltransferase activity, NAD+ ADP-ribosyltransferase activity, NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT6 itself. We selected most functions SIRT6 had, and list some proteins which have the same functions with SIRT6. You can find most of the proteins on our site.
|NAD(P)+-protein-arginine ADP-ribosyltransferase activity||CHAT2; MADPRT; ART5; SIRT6; ART3; Art2b; CHAT1; ART1|
|NAD+ ADP-ribosyltransferase activity||SIRT4; GIG2O; GIG2I; ART5; GIG2K; GIG2G; PARP16; GIG2E; TNKS; GIG2D|
|NAD+ binding||GLUD1; HADH; HPGD; SIRT4; SIRT3; SIRT7; SIRT2; ALDH1A3; SIRT1; SIRT6|
|NAD-dependent histone deacetylase activity||SIRT1; SIRT6; SIRT2|
|NAD-dependent histone deacetylase activity (H3-K9 specific)||SIRT1; SIRT6|
|chromatin binding||PSIP1; HDAC3; CHAF1B; FOS; MB21D2; GATA6; KLF14; TLE1; Trl; GATA5|
|protein binding||ZMYND19; DSCC1; WDR24; PDGFRA; NDUFB10; MAP4K4; MRAP2; BRAF; TNFRSF11A; WDR77|
|transcription corepressor activity||RCOR2; SMARCA4; TLE4; HIRA; ZNF593; BCOR; TFAP2B; ZMYND11; TBL1X; NR0B1|
|zinc ion binding||GLI2; MMP19; TRIM43B; MAN2A1; NR4A2A; RNF112; DBF4; TAF15; FBXL19; CA4|
SIRT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT6.
RELA; VIM; CHD3; MYC; a8k1f4_human; MLF1; HSF2; PSMD2; q96be0_human; AARSD1; FKBPL; STUB1; UBE2D1