sirt6
Share
  • Official Full Name
  • sirtuin 6
  • Background
  • The Silent Information Regulator (SIR2) family of genes is a highly conserved group of genes that encode nicotinamide adenine dinucleotide (NAD)-dependent protein deacetylases, also known as Class III histone deacetylases. The first discovered and best ch
  • Synonyms
  • SIRT6; sirtuin 6; sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 6; NAD-dependent deacetylase sirtuin-6; sirtuin type 6; SIR2-like protein 6
Cat.#:SIRT6-213HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT6 protein, T7/His-tagged
+Inquiry
Cat.#:SIRT6-2684HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT6, GST-tagged
+Inquiry
Cat.#:SIRT6-28517THTag:T7
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human SIRT6, T7 -tagged
+Inquiry
Cat.#:SIRT6-357HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 6, His-tagged
+Inquiry
Cat.#:SIRT6-4882HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Sirtuin 6, His-tagged
+Inquiry
Cat.#:SIRT6-4883HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Sirtuin 6, GST-tagged
+Inquiry
Cat.#:Sirt6-1381MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Sirt6 protein, His-tagged
+Inquiry
Cat.#:Sirt6-1382RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Sirt6 protein, His-tagged
+Inquiry
Cat.#:SIRT6-3378CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken SIRT6
+Inquiry
Cat.#:SIRT6-304ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish SIRT6
+Inquiry
Cat.#:SIRT6-1829HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human SIRT6 293 Cell Lysate
+Inquiry
Cat.#:Kit-2341Tag:
Source (Host):Species:
Product nameSIRT6 Inhibitor Screening Kit (Fluorometric)
+Inquiry

Involved Pathway

SIRT6 involved in several pathways and played different roles in them. We selected most pathways SIRT6 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SIRT6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Central carbon metabolism in cancer
KIT; MAPK3; HK1; PDGFRA; PIK3CA; SCO2; NTRK3; RET; PIK3R3; TRP53

Protein Function

SIRT6 has several biochemical functions, for example, NAD(P)+-protein-arginine ADP-ribosyltransferase activity, NAD+ ADP-ribosyltransferase activity, NAD+ binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SIRT6 itself. We selected most functions SIRT6 had, and list some proteins which have the same functions with SIRT6. You can find most of the proteins on our site.
Function
Related Protein
Function NAD(P)+-protein-arginine ADP-ribosyltransferase activity
Related Protein SIRT6; CHAT1; Art2b; ART1; ART3; MADPRT; ART5; CHAT2
Function NAD+ ADP-ribosyltransferase activity
Related Protein SIRT4; TNKS; PARP12A; GIG2H; PARP11; GIG2G; GIG2Q; PARP1; PARP15; GIG2O
Function NAD+ binding
Related Protein ALDH1A3; SIRT7; SIRT3; HADH; SIRT6; HPGD; SIRT5; SIRT2; SIRT4; GLUD1
Function NAD-dependent histone deacetylase activity
Related Protein SIRT2; SIRT6; SIRT1
Function NAD-dependent histone deacetylase activity (H3-K9 specific)
Related Protein SIRT1; SIRT6
Function chromatin binding
Related Protein MEN1; HIF1AB; KAT2B; PRKCBB; RNF20; CENPB; ANKRD17; RNF168; ARID3C; SKIL
Function protein binding
Related Protein IFI16; SLC30A3; HDAC7A; PHF8; ANGPTL4; RFC5; CCL5; FOXR2; SLA2; SCUBE3
Function transcription corepressor activity
Related Protein TLE4; LHX9; SKOR1A; SMYD1; SSX5; TRIB3; HOMEZA; ID4; MXD4; SNW1
Function zinc ion binding
Related Protein SUV39H2; NR2F1; USP51; CPO; PRKCBA; Car8; TRHDE; LMO2; NR2E1; MME

Interacting Protein

SIRT6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SIRT6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SIRT6.
RELA; VIM; CHD3; MYC; a8k1f4_human; MLF1; HSF2; PSMD2; q96be0_human; AARSD1; FKBPL; STUB1; UBE2D1

SIRT6 Related Articles

Tahir, MN; Ragg, R; et al. Amine functionalized ZrO2 nanoparticles as biocompatible and luminescent probes for ligand specific cellular imaging. JOURNAL OF MATERIALS CHEMISTRY B 3:2371-2377(2015).
Orellana, ME; Quezada, C; et al. Expression of SIRT2 and SIRT6 in Retinoblastoma. OPHTHALMIC RESEARCH 53:100-108(2015).