Active Recombinant Human SIRT6 Protein, GST-tagged
Cat.No. : | SIRT6-28517H |
Product Overview : | Human Sirtuin 6 (GenBank Accession No. NM_016539), full length with N-terminal GST-tag was expressed in an E. coli expression system. |
- Specification
- Gene Information
- Related Products
Description : | This gene encodes a member of the sirtuin family of NAD-dependent enzymes that are implicated in cellular stress resistance, genomic stability, aging and energy homeostasis. The encoded protein is localized to the nucleus, exhibits ADP-ribosyl transferase and histone deacetylase activities, and plays a role in DNA repair, maintenance of telomeric chromatin, inflammation, lipid and glucose metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. |
Source : | E.coli |
Species : | Human |
Tag : | GST |
Form : | Aqueous buffer solution |
Bio-activity : | 1.5 pmol/min/µg Assay Conditions: 25 mM Tris/HCl, pH 8.0, 137 mM NaCl, 2.7 mM KCl, 1 mM MgCl2, and 0.1 mg/ml BSA, 20 µM BPS SIRT6 substrate 2, 500 µM NAD+ and Sirtuin 6 (18 – 2000 ng). Incubation condition: 60 min at 37ºC followed by developing for 15 min at room temperature. |
Molecular Mass : | 65 kDa |
Applications : | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. |
Storage : | At least 6 months at –80 centigrade. Avoid freeze/thaw cycles. |
Storage Buffer : | 40 mM Tris-HCl, pH 8.0, 110 mM NaCl, 2.2 mM KCl, 16 mM glutathione, 20% glycerol |
Warning : | Avoid freeze/thaw cycles. |
Gene Name : | SIRT6 sirtuin 6 [ Homo sapiens (human) ] |
Official Symbol : | SIRT6 |
Synonyms : | SIRT6; sirtuin 6; SIR2L6; NAD-dependent protein deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6; EC 2.4.2.31 |
Gene ID : | 51548 |
mRNA Refseq : | NM_016539 |
Protein Refseq : | NP_057623 |
MIM : | 606211 |
UniProt ID : | Q8N6T7 |
Products Types
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◆ Lysates | ||
SIRT6-1829HCL | Recombinant Human SIRT6 293 Cell Lysate | +Inquiry |
◆ Assay kits | ||
Kit-2341 | SIRT6 Inhibitor Screening Kit (Fluorometric) | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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